DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ft and Cdhr2

DIOPT Version :9

Sequence 1:NP_477497.1 Gene:ft / 33627 FlyBaseID:FBgn0001075 Length:5147 Species:Drosophila melanogaster
Sequence 2:NP_001028536.2 Gene:Cdhr2 / 268663 MGIID:2687323 Length:1308 Species:Mus musculus


Alignment Length:1530 Identity:383/1530 - (25%)
Similarity:594/1530 - (38%) Gaps:410/1530 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1467 PSLSTTVLYNVLVVDDNDNPPIFPSTAIVRQIKEGIPLKTPIVTVTADDPDSGLNGKVSYAISKQ 1531
            |:...:|..|        :||.|.....:..:.|.:|:......:.|.|.|   |..::|.||. 
Mouse    12 PAFMVSVTAN--------SPPSFGVNMTLVTLPEDLPVGAVAFWLVATDSD---NDHLTYGISG- 64

  Fly  1532 EPQLPQGRHFGINTETGVIHTLREIDRESIDTFRLTVVATD--RAQPSERQLSTEKLVTVIVEDI 1594
                |...:|.:|..||.:.....:|.|::..|::|:..:|  ..:.:|.|        |||||.
Mouse    65 ----PNASYFSVNANTGEVKLASPLDFETVPFFKITISTSDGLNIRTAEMQ--------VIVEDR 117

  Fly  1595 NDNAPVFVSMNAAILPPKFSTSKGSS----TAVMQVHAKDADSSSNGLVTYEI------VSGPQE 1649
            |||.|||       |..:||||...:    :.|..|.|:|.|:.:.|||.|.|      .:....
Mouse   118 NDNIPVF-------LNTEFSTSINETLPVGSVVFSVLAEDKDTGTAGLVQYFIEKVIPSTANSNN 175

  Fly  1650 LFKLQRNTGIITFTPGPQFKQEVRYQLTLKSTDEAVQSERR-----SSEVYITIITPGSGGSESS 1709
            ||::..|..|:.........:...|||.||:.|.....:.:     |..|:::|       |...
Mouse   176 LFRILENGSIVLNDTLSYNNKSAFYQLELKACDSGGILDNKPKTQCSQPVFVSI-------SVID 233

  Fly  1710 VPQFEQ---RSKLSGSVYENEPIGTSILTVTAHLASAEIE----YFVTNVTATGSRGQVDRLFDI 1767
            .|..:.   |...|.||.|:..:|||:|||.|..:...|.    |.|:|.|..|       .|||
Mouse   234 EPDLDPRFIREFYSASVAEDATLGTSVLTVEAVDSDKGINDIVTYSVSNSTRPG-------WFDI 291

  Fly  1768 DAKLGILSTAAELDRE---AGPEEYEVEVYA----IALGGQPRTSRTKVRVTVLDKNDSPPQFLD 1825
             .:.|::.....||||   ...||.:::|.|    :.:.||...:...|.:.|.|.||..|:|  
Mouse   292 -REDGVIFVNGSLDREQLLLENEEVQIQVTATEKNLNIYGQEAKASMWVTIRVTDVNDHKPEF-- 353

  Fly  1826 TPFVYNVS--------EDLQ---IGHT-------IS----TLRAHDPDTLGSVTFLL-MDGHDGK 1867
                ||.|        ::.|   ||:.       ||    |:.|:|||...:.|||| ::|.|.:
Mouse   354 ----YNCSLPGCSFSPQEAQVNFIGYVDEHASARISIDGLTMVAYDPDQGDNGTFLLSLNGQDAE 414

  Fly  1868 -FLLEP--STGKLIL------NDTLDRETKSKYELRIRVSDGV--QYTEAYATIQVSDTNDNPPL 1921
             |.:.|  :.|.:.:      ::.:|.|.::...:.:..:|.|  .|:.|..||.:.:.||:.|:
Mouse   415 AFNVSPERAAGSVSVQVVVRNSEMVDYEKETVMVVEVVATDSVSNNYSVATVTIHLRNINDHRPV 479

  Fly  1922 FEDTVYSFDIPENAQRGYQV-GQIVARDADLGQNAQLSYGVVSDWANDVFSLNPQTGMLTLT--A 1983
            |..::|...:||:...||.| .:|.|.|.|..:...::|.::.....|:|.:.|.:|.||:.  .
Mouse   480 FSQSLYELTVPEHCPTGYLVTDKIQATDLDGDEWGPITYSLLPGNGADLFEVEPNSGNLTVKNGT 544

  Fly  1984 RLDYEEVQHYILIVQAQDNGQPSLSTTITVYCNVLDLNDNAPIFDPMSYSSEVF---ENVPIATE 2045
            .||.|:...|.|.:||.|.|..|.:|.:.:  .:||:|||.|:   :..|..||   ||..::  
Mouse   545 LLDREKQAVYYLTLQATDGGNQSTTTALEI--TLLDINDNPPV---VRGSYNVFVPEENGNVS-- 602

  Fly  2046 VVTVSAKDID--SGNNGLIEYSITAGDVDSEFGIDSN-GTIRTRRNLDREH-----RSTYTLTVT 2102
             ||:.|.|.|  ..||.|:.:|:..|...|.|.:|.| |.:|....||||.     .....|||.
Mouse   603 -VTIQAYDDDQPDTNNSLLVFSLLPGPYSSNFSLDPNTGLLRNLGPLDREAIDPALEGRIVLTVI 666

  Fly  2103 ARDCADEFASFSELEETQLKLKYRSPRKYQQTRQEFLAHQKQQRLSSTVKVTILIKDVNDEVPVF 2167
            ..||.                                    :..||:.|.|||.::|:||.:|||
Mouse   667 VADCG------------------------------------EPSLSTNVNVTITVEDINDNLPVF 695

  Fly  2168 ISANETAIMENVAINTVVIAVKAVDNDEGRNGYIDYLMKEARDEDMGQSDPLPFSLNPT------ 2226
            ..:.|.::.|.|. ...|..|||.|.|:                 ...::.:.|||:.|      
Mouse   696 NQSYEFSVWERVP-GAWVGTVKAWDADQ-----------------TAANNRISFSLSGTGANNFI 742

  Fly  2227 -----------DGQLRVVD--ALDRELRSSYLLNITARDRGEPPQSTES--QLLIRILDENDNSP 2276
                       :|.|.::.  .||.|.:..:.|.::|.:.|  ||..:|  .:.:.::|.||..|
Mouse   743 LQGNVLEQGWAEGSLWLLPDVRLDYETQKFFHLTVSAENPG--PQGLDSTANVTVTVMDVNDEPP 805

  Fly  2277 VFDPKQYSA-SVAENASIGAMVLQVSATDVDEGANGRI--------RYSIVLGDQNHD-FSISED 2331
            ..|.....| ||.||.|....|.:|.|.|||..|..||        :..:.:|...|. ||:..:
Mouse   806 TLDAASLQAISVTENGSEHGQVTRVIAQDVDTAALLRIELVDVICTKAGVDVGSVCHGWFSVDGN 870

  Fly  2332 TGV-VRVAKNLNYERLSRYSLTVRAEDCALENPAGD----TAELTINILDINDNRPTFLDSPYLA 2391
            ..| :..::.::||.....:|.|||.|...: |..|    ...|.|||.|.|||.|.||.:....
Mouse   871 GSVYINQSEAIDYEACHLVTLVVRAYDLNTD-PGFDAYSSNGSLLINIKDKNDNAPYFLPNNQTF 934

  Fly  2392 RVMENTVPPNGGYVLTVNAYDADTPPLNSQVRYFL-------KEGDSD---LFRINAS------S 2440
            .::...|.|| ..|.:|.|.|.|:.. |..:.:.:       |:|.|:   :|||..|      :
Mouse   935 VIIPELVLPN-QQVASVQARDEDSED-NGIIMFSILKAEFVRKDGTSNPVQVFRITRSVEAGLFT 997

  Fly  2441 GDIALLKPLDREQQSEYTLTLVAMDTGSPPLTGTGIVRVEVQDINDNDPVFELQSYHATVRENLP 2505
            |.|.|:..||...|..|.:|:.|.|   .|..|               |..|.|:          
Mouse   998 GSIELVTNLDSTIQGTYQVTVQAQD---QPTLG---------------PALETQT---------- 1034

  Fly  2506 SGTHVLTPRATDKDEGLNAKLRFNLLGEHMHRFHIDSETGEISTATTLDREETSVYHLTLMAQDS 2570
                  |......|:....:|:|:...|     .:.:...||..| .:....||||.:|:...||
Mouse  1035 ------TLNLFTVDQSYRVRLQFSTSKE-----DVGANMEEIKEA-LIQATRTSVYVVTIQNIDS 1087

  Fly  2571 SITEPRASSVNLTISVSDVNDNIPKFDSTTYNVAVPERISKGEFVFGARALDLDDGENAVVHYTI 2635
            : ...||||.                                        :|.            
Mouse  1088 T-ARARASSY----------------------------------------MDA------------ 1099

  Fly  2636 SGRDQHYFDINTKTGVVSTKLELKTKTKSHDDLTY-----TIVISAMDQGE---QSLSSKA---- 2688
                  ||..:..|.:..|:|.:..: |..|.|..     .:|:|:.:..|   |.|.:..    
Mouse  1100 ------YFVFSNGTALTLTELNMMIR-KDQDALRQLLQLGLVVVSSQESQEPDQQKLLTSVIIGL 1157

  Fly  2689 ELTVILRPPELFPTFAYMANSHFAMSEDVRPGKMI--TKVSATSPKKGLVGKIRYAIAGGIMGDS 2751
            .::::|....|......:..|:......::.||..  |.:..|:|..        ||.|..|.::
Mouse  1158 VVSLVLVLVILITALVCLRKSYHRKLRAMKAGKEARKTPIETTAPTA--------AIPGTNMYNT 1214

  Fly  2752 LRVDP-------NSGLLSVGQDGLDYELTHLYEIWIEAADGDTPSLRSVTLITLNVTDANDNAPV 2809
            .|.:|       :.||.......|||:                         :||..|.|.....
Mouse  1215 DRANPVLDLPTKDLGLECHSSSDLDYD-------------------------SLNSLDENSVDLD 1254

  Fly  2810 MEQLIYNAEVL----EEESPPQLIAVVKASDRDSG 2840
            |:...:..:.|    .|..|..|.||:  |.|.:|
Mouse  1255 MDSKEFKRKDLPGDPPEPDPEPLTAVL--SGRSAG 1287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ftNP_477497.1 Cadherin_repeat 71..152 CDD:206637
Cadherin_repeat 163..266 CDD:206637
Cadherin_repeat 275..378 CDD:206637
Cadherin_repeat 393..490 CDD:206637
Cadherin_repeat 498..594 CDD:206637
Cadherin_repeat 603..704 CDD:206637
Cadherin_repeat 735..814 CDD:206637
Cadherin 843..>907 CDD:278457
Cadherin 950..1026 CDD:278457
Cadherin_repeat 1053..1149 CDD:206637
Cadherin_repeat 1157..1274 CDD:206637
Cadherin_repeat 1282..1380 CDD:206637
Cadherin_repeat 1390..1485 CDD:206637 3/17 (18%)
Cadherin_repeat 1497..1597 CDD:206637 27/101 (27%)
Cadherin_repeat 1621..1699 CDD:206637 22/88 (25%)
Cadherin_repeat 1720..1818 CDD:206637 34/108 (31%)
Cadherin_repeat 1827..1918 CDD:206637 31/124 (25%)
Cadherin_repeat 1926..2023 CDD:206637 31/99 (31%)
Cadherin_repeat 2031..2162 CDD:206637 37/141 (26%)
Cadherin_repeat 2172..2274 CDD:206637 26/122 (21%)
Cadherin_repeat 2282..2380 CDD:206637 35/112 (31%)
Cadherin_repeat 2388..2487 CDD:206637 28/114 (25%)
Cadherin_repeat 2495..2592 CDD:206637 19/96 (20%)
Cadherin_repeat 2600..2694 CDD:206637 14/105 (13%)
Cadherin_repeat 2710..2806 CDD:206637 20/104 (19%)
Cadherin_repeat 2814..2909 CDD:206637 9/31 (29%)
Cadherin_repeat 2917..3009 CDD:206637
Cadherin 3018..3114 CDD:278457
Cadherin 3129..3220 CDD:278457
Cadherin_repeat 3233..3330 CDD:206637
Cadherin_repeat 3338..3434 CDD:206637
Cadherin_repeat 3443..3541 CDD:206637
Cadherin_repeat 3550..3647 CDD:206637
Cadherin_repeat 3657..3753 CDD:206637
EGF 4017..4047 CDD:278437
EGF_CA 4056..4090 CDD:238011
EGF_CA 4094..4128 CDD:238011
Laminin_G_1 4156..4306 CDD:278483
LamG 4428..4543 CDD:238058
Cdhr2NP_001028536.2 Cadherin_repeat 33..120 CDD:206637 27/102 (26%)
Cadherin_repeat 128..236 CDD:206637 28/114 (25%)
Cadherin_repeat 246..349 CDD:206637 35/110 (32%)
Cadherin_repeat 372..476 CDD:206637 27/103 (26%)
Cadherin_repeat 485..582 CDD:206637 31/98 (32%)
Cadherin_repeat 589..691 CDD:206637 38/140 (27%)
Cadherin_repeat 698..802 CDD:206637 25/123 (20%)
Cadherin_repeat 815..923 CDD:206637 34/108 (31%)
Cadherin_repeat 934..1042 CDD:206637 32/143 (22%)
Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000250|UniProtKB:Q9BYE9 1178..1308 31/145 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1251..1308 10/39 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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