DRSC/TRiP Functional Genomics Resources

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Protein Alignment ft and GAS6

DIOPT Version :10

Sequence 1:NP_477497.1 Gene:ft / 33627 FlyBaseID:FBgn0001075 Length:5147 Species:Drosophila melanogaster
Sequence 2:NP_000811.1 Gene:GAS6 / 2621 HGNCID:4168 Length:678 Species:Homo sapiens


Alignment Length:794 Identity:166/794 - (20%)
Similarity:264/794 - (33%) Gaps:284/794 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  3909 LQLLMAVRLAKTSY----QQPKYLIERLREKRSAFSEL----LQKEVIVGYEPCSEPDVCENGGV 3965
            |.||:|...|..:.    :..::|..|.|.....|.|.    |::|.:  .|.||..:..|    
Human    19 LLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECV--EELCSREEARE---- 77

  Fly  3966 CSATMRLLDAHSFVIQDSPALVLSGPR---VVHDYSCQCT--SGFSGEQCSRR-QDPCLPNPCHS 4024
                         |.::.|......||   .::.|....|  |||:  .|.:. .|.|.||||..
Human    78 -------------VFENDPETDYFYPRYLDCINKYGSPYTKNSGFA--TCVQNLPDQCTPNPCDR 127

  Fly  4025 Q--VQCRRLGSDFQCMCPANRDGKHCEKERSD----------VCYSKP------CRNG------- 4064
            :  ..|:.|..:|.|:|.|...|:.|:|:.::          :|::||      |.:|       
Human   128 KGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDG 192

  Fly  4065 -----------------GSCQRSPDGSSYFCLCRPGFRGNQCESVSDSCRP-NPCLHG---GLCV 4108
                             ..|:..|  .||.|||..||..:..|.   :||. :.||.|   .:||
Human   193 RTCQDIDECADSEACGEARCKNLP--GSYSCLCDEGFAYSSQEK---ACRDVDECLQGRCEQVCV 252

  Fly  4109 SLKPGYKCNCTPGRYGRH-------------CERFS-------------YGFQPLSYMTFPALDV 4147
            :....|.|:| .||.|..             |..||             :...|:..:.|..|..
Human   253 NSPGSYTCHC-DGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQP 316

  Fly  4148 TTNDISIVFATTKPNSLLLYNYGMQSGGRSD--FLAIELVHGRAYFS---SGGARTAISTVIAGR 4207
            |.......|.|..|..:||:     :||..|  ::.:.|..||....   :|..|...|    |.
Human   317 TRLVAEFDFRTFDPEGILLF-----AGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSS----GP 372

  Fly  4208 NLADGGWHKVTATRNGRVMSL-----SVAKCADSGDVCTECLPGDSSCYADEVGPVGTLNFNKQP 4267
            .:..|.|..::.....|.:.:     :|.|.|.:||:           :..|.| :..||     
Human   373 VINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDL-----------FQPERG-LYHLN----- 420

  Fly  4268 LMIGGLSSADPILERPGQVHSDDLV--------GCLHSVH-IGGRALNLSLPLQQKGILAGCNRQ 4323
            |.:||:           ..|..|||        ||:.|.: :.|....:     |:.:......|
Human   421 LTVGGI-----------PFHEKDLVQPINPRLDGCMRSWNWLNGEDTTI-----QETVKVNTRMQ 469

  Fly  4324 ACQPALAAER-----CGGFAGQCIDRWSSSLCQCGGHLQSPDCSDSLEPITLGEGAFVEFRISEI 4383
            ...   ..||     ..|||...:|           ::::|                        
Human   470 CFS---VTERGSFYPGSGFAFYSLD-----------YMRTP------------------------ 496

  Fly  4384 YRRMQLLDNLYNSKSAWLDNQQMRERRAVSNFSTASQIYEAPKMLSMLFRTYKDQGQILYAATNQ 4448
                  ||  ..::|.|       |...|::...|:                 |.| :|:|....
Human   497 ------LD--VGTESTW-------EVEVVAHIRPAA-----------------DTG-VLFALWAP 528

  Fly  4449 MFTSLSLREGRLVYYS----KQHLTINMTVQETS------TLNDGKWHNVSLFSESRSLRLIVDG 4503
            ...::.|....:.|:|    |:.|.: :.|:.|:      .:.||:.|.|::........|.|||
Human   529 DLRAVPLSVALVDYHSTKKLKKQLVV-LAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDG 592

  Fly  4504 RQVGDELDIAGVHDFL--------DPYLTILNVGG-----------EAFV-GCLANVTVNNELQP 4548
            .:...|:..|.:.:.|        .|.||.  .||           .||. ||: .:.||..|..
Human   593 TRGQSEVSAAQLQERLAVLERHLRSPVLTF--AGGLPDVPVTSAPVTAFYRGCM-TLEVNRRLLD 654

  Fly  4549 LNGSGSIFPEVRYH 4562
            |:.:.....::..|
Human   655 LDEAAYKHSDITAH 668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ftNP_477497.1 Cadherin_repeat 71..152 CDD:206637
Cadherin_repeat 163..266 CDD:206637
Cadherin_repeat 275..378 CDD:206637
Cadherin_repeat 393..490 CDD:206637
Cadherin_repeat 498..594 CDD:206637
Cadherin_repeat 603..704 CDD:206637
Cadherin_repeat 735..814 CDD:206637
Cadherin 843..>907 CDD:394985
Cadherin 950..1026 CDD:394985
Cadherin_repeat 1053..1149 CDD:206637
Cadherin_repeat 1157..1274 CDD:206637
Cadherin_repeat 1282..1380 CDD:206637
Cadherin_repeat 1390..1485 CDD:206637
Cadherin_repeat 1497..1597 CDD:206637
Cadherin_repeat 1621..1699 CDD:206637
Cadherin_repeat 1720..1818 CDD:206637
Cadherin_repeat 1827..1918 CDD:206637
Cadherin_repeat 1926..2023 CDD:206637
Cadherin_repeat 2031..2162 CDD:206637
Cadherin_repeat 2172..2274 CDD:206637
Cadherin_repeat 2282..2380 CDD:206637
Cadherin_repeat 2388..2487 CDD:206637
Cadherin_repeat 2495..2592 CDD:206637
Cadherin_repeat 2600..2694 CDD:206637
Cadherin_repeat 2710..2806 CDD:206637
Cadherin_repeat 2814..2909 CDD:206637
Cadherin_repeat 2917..3009 CDD:206637
Cadherin 3018..3114 CDD:394985
Cadherin 3129..3220 CDD:394985
Cadherin_repeat 3233..3330 CDD:206637
Cadherin_repeat 3338..3434 CDD:206637
Cadherin_repeat 3443..3541 CDD:206637
Cadherin_repeat 3550..3647 CDD:206637
Cadherin_repeat 3657..3753 CDD:206637
EGF 4017..4047 CDD:394967 12/31 (39%)
EGF_CA 4056..4090 CDD:238011 14/63 (22%)
EGF_CA 4094..4128 CDD:238011 13/50 (26%)
Laminin_G_1 4156..4306 CDD:395008 38/168 (23%)
LamG 4428..4543 CDD:238058 31/144 (22%)
GAS6NP_000811.1 Gla 53..92 CDD:459861 11/57 (19%)
FXa_inhibition 160..195 CDD:464251 5/34 (15%)
EGF_CA 197..>227 CDD:214542 7/31 (23%)
FXa_inhibition 245..277 CDD:464251 9/32 (28%)
LamG 298..450 CDD:238058 41/188 (22%)
Laminin_G_2 513..644 CDD:460494 31/151 (21%)
Blue background indicates that the domain is not in the aligned region.

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