DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ft and CDHR3

DIOPT Version :9

Sequence 1:	NP_477497.1	Gene:	ft / 33627	FlyBaseID:	FBgn0001075	Length:	5147	Species:	Drosophila melanogaster
Sequence 2:	NP_689963.2	Gene:	CDHR3 / 222256	HGNCID:	26308	Length:	885	Species:	Homo sapiens

Alignment Length:	706	Identity:	188/706 - (26%)
Similarity:	299/706 - (42%)	Gaps:	144/706 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1523 KVSYAISKQEPQLPQ-----------------GRHFGINTETGVIHTLREIDRES-IDTFRLTVV 1569
            |:|.::|...|..||                 |.:|.:.| ||    :.::|.|: .:.|.|.:.
Human    47 KLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVT-TG----MEQLDFETGPNIFDLQIY 106

  Fly  1570 ATDRAQPSERQLSTEKLVTVIVEDINDNAPVFVSMNAAILPPKFS-----------TSKGSSTAV 1623
            ..|....::.|     ::||.|.|:|:             ||:|.           ..:.:...:
Human   107 VKDEVGVTDLQ-----VLTVQVTDVNE-------------PPQFQGNLAEGLHLYIVERANPGFI 153

  Fly  1624 MQVHAKD-ADSSSNGLVTYEIVSGPQELFKLQRNTGIITFTPGPQFKQEVR-YQLTLKSTDEAVQ 1686
            .||.|.| .|:|.|..::|.::|.|:. |::..| |.:..|....|:...| :.|.::..|..
Human   154 YQVEAFDPEDTSRNIPLSYFLISPPKS-FRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSG-- 214

  Fly  1687 SERRSSEVYITIITPGSGGSESSVPQFEQRSKLSGSVYENEPIGTSILTVTAHLASAE-----IE 1746
            ..:.|:|:.:.|:     .....||:|...:::...:.|..| ||.:..:||.....|     :.
Human   215 GLKASTELQVNIV-----NLNDEVPRFTSPTRVYTVLEELSP-GTIVANITAEDPDDEGFPSHLL 273

  Fly  1747 YFVTNVTATGSRGQVDRLFDIDAKLGILSTAAELDREAG-----PE-EYEVEVYAIALGGQPRTS 1805
            |.:|.|:         :.|.|:...|.:..|..:||:||     |. ..||.|.....|||  .:
Human   274 YSITTVS---------KYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQ--EN 327

  Fly  1806 RTKVRVTVLDKNDSPPQFLDTPFVYNVSEDLQIGHTISTLR-------AHDPDTLGSVTFLLMDG 1863
            |.::...|.|.||:|.......|...|.|....|..:..|.       :..|:...:.|.....|
Human   328 RIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVG 392

  Fly  1864 HDGKFLLEPS-TGKLILNDTLDRETKS------KYELRIRVSD-GVQY--TEAYATIQVSDTNDN 1918
            ...:||.:|: :||::|...||.|..|      ||.:.|:|.| ...|  ...|..|..|..|:.
Human   393 SGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEF 457

  Fly  1919 PPLFEDTVYSFDIPENAQRGYQVGQIVARDADLGQNAQLSYGVVSDWAN----DVFSLNPQTGML 1979
            |.:|:...|.||:.|......:|||:.|.|.||.|:: |.|.:.:..|:    :||.:||:||.|
Human   458 PLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSS-LLYSISTGGASLQYPNVFWINPKTGEL 521

  Fly  1980 TLTARLDYEEVQHYILIVQAQDNGQPSLSTTITVYCNVLDLNDNAPIFDPMSYSSEVFENVPIAT 2044
            .|..::|.|....|||.:||.:|...| |.|:||  |:|:.||..||..|.||    |..:|:..
Human   522 QLVTKVDCETTPIYILRIQATNNEDTS-SVTVTV--NILEENDEKPICTPNSY----FLALPVDL 579

  Fly  2045 EVVT------VSAKDIDSGNNGLIEYSITAGDVDSEFGIDSN-GTIRTRRNLDREHRSTYTLTVT 2102
            :|.|      ::..|:||.... ..|||..|:|::.|....| |:..||            |.:|
Human   580 KVGTNIQNFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSNVTR------------LLLT 631

  Fly  2103 ARDCADEFASFSELEETQLKLKYRSPRKYQQTRQEFLAHQKQQRLSSTVKVTILIK 2158
            :|  .|....|.::.:.:| |.|.:.......|      :|.:.|..|..||:.||
Human   632 SR--FDYAGGFDKIWDYKL-LVYVTDDNLMSDR------KKAEALVETGTVTLSIK 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ft	NP_477497.1	Cadherin_repeat	71..152	CDD:206637
		Cadherin_repeat	163..266	CDD:206637
		Cadherin_repeat	275..378	CDD:206637
		Cadherin_repeat	393..490	CDD:206637
		Cadherin_repeat	498..594	CDD:206637
		Cadherin_repeat	603..704	CDD:206637
		Cadherin_repeat	735..814	CDD:206637
		Cadherin	843..>907	CDD:278457
		Cadherin	950..1026	CDD:278457
		Cadherin_repeat	1053..1149	CDD:206637
		Cadherin_repeat	1157..1274	CDD:206637
		Cadherin_repeat	1282..1380	CDD:206637
		Cadherin_repeat	1390..1485	CDD:206637
		Cadherin_repeat	1497..1597	CDD:206637	22/91 (24%)
		Cadherin_repeat	1621..1699	CDD:206637	20/79 (25%)
		Cadherin_repeat	1720..1818	CDD:206637	28/108 (26%)
		Cadherin_repeat	1827..1918	CDD:206637	28/107 (26%)
		Cadherin_repeat	1926..2023	CDD:206637	39/100 (39%)
		Cadherin_repeat	2031..2162	CDD:206637	35/135 (26%)
		Cadherin_repeat	2172..2274	CDD:206637
		Cadherin_repeat	2282..2380	CDD:206637
		Cadherin_repeat	2388..2487	CDD:206637
		Cadherin_repeat	2495..2592	CDD:206637
		Cadherin_repeat	2600..2694	CDD:206637
		Cadherin_repeat	2710..2806	CDD:206637
		Cadherin_repeat	2814..2909	CDD:206637
		Cadherin_repeat	2917..3009	CDD:206637
		Cadherin	3018..3114	CDD:278457
		Cadherin	3129..3220	CDD:278457
		Cadherin_repeat	3233..3330	CDD:206637
		Cadherin_repeat	3338..3434	CDD:206637
		Cadherin_repeat	3443..3541	CDD:206637
		Cadherin_repeat	3550..3647	CDD:206637
		Cadherin_repeat	3657..3753	CDD:206637
		EGF	4017..4047	CDD:278437
		EGF_CA	4056..4090	CDD:238011
		EGF_CA	4094..4128	CDD:238011
		Laminin_G_1	4156..4306	CDD:278483
		LamG	4428..4543	CDD:238058
CDHR3	NP_689963.2	Cadherin_repeat	26..128	CDD:206637	21/90 (23%)
		Cadherin_repeat	141..231	CDD:206637	21/98 (21%)
		Cadherin_repeat	242..341	CDD:206637	29/110 (26%)
		Cadherin_repeat	349..456	CDD:206637	27/106 (25%)
		Cadherin_repeat	465..561	CDD:206637	38/99 (38%)
		Cadherin_repeat	570..679	CDD:206637	35/135 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	808..885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910