DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ft and FAT2

DIOPT Version :9

Sequence 1:	NP_477497.1	Gene:	ft / 33627	FlyBaseID:	FBgn0001075	Length:	5147	Species:	Drosophila melanogaster
Sequence 2:	NP_001438.1	Gene:	FAT2 / 2196	HGNCID:	3596	Length:	4349	Species:	Homo sapiens

Alignment Length:	4462	Identity:	1120/4462 - (25%)
Similarity:	1774/4462 - (39%)	Gaps:	961/4462 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 QYEIVAGNVDNKFRLVTTANPSGDTSYLHLET----TGNLDRESRGSYQLNISARDGGSPPRFGY 253
            :|.|::|:|.|.|:  |.....|:..:|.:.|    |..|:||.|.||.|.|.|.: .:......
Human    70 RYRIISGDVANVFK--TEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATE-KTLELEAL 131

  Fly   254 LQVNVTILDVNDNPPIFDHSDYNVSLNETALPGTPVVTVMASDNDLGDNSKITYYLAETEHQFTV 318
            .:|.|.|||.||..|:|....|.|:::|.....:|:..|.|:|.|||.|::..|........|.:
Human   132 TRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAI 196

  Fly   319 NPETGVISTTERVNCPQQTNVKSSASQKSCVFTVFARDHGSPRQDGRTYVTVNLLDTNDHDPIIS 383
            :|.:||::...::|...:...:         ..|.|.|......:|..:.::..|..: .:|  :
Human   197 HPTSGVVTVAGKLNVTWRGKHE---------LQVLAVDRMRKISEGNGFGSLAALVVH-VEP--A 249

  Fly   384 FRFFPDGGKVATVDENAVNGTVVAAVAVKDSDSGLNGRTSVRIVSGNELGHFR----LEEAADLH 444
            .|..|....|.....::.:||..|.|.|..:.||.... ||.:|.|:...||:    ...:.:..
Human   250 LRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVE-SVEVVGGDPGKHFKAIKSYARSNEFS 313

  Fly   445 IVRVNGVLDREEIGKYNLTVVAMDQGTP---ARTTTAHLIIDVNDVNDHEP------VFEKSEYS 500
            :|.|..:...|.:..:||::.|.....|   ::....||          .|      .|||:.|.
Human   314 LVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHL----------PPSKLSSLKFEKAVYR 368

  Fly   501 AVLSELAPTGSFVASITATDEDTGVNAQVHYDILSGNELKWFSMDPLTGLIVTTGPLDREIRDTV 565
            ..|||.:|.||.|..:..|.    ....:.|.:...:|...|.::..||||.||..:|...|...
Human   369 VQLSEFSPPGSRVVMVRVTP----AFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHY 429

  Fly   566 ELSISARDGGPNPKFAYTQLKVIILDENDEAPQFSQREQNVTLGEDAPPQTIVALMTATDHDQGT 630
            :|.|..     :|..|.|.:.:.|:|.|:.||.|::...:.||.|:.||.|.|..:||||.|.|.
Human   430 QLHIRT-----SPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGE 489

  Fly   631 NGSVTFALA-PSVERLYPLQFALDALTGQLTTRRPLDREKMSQ-YEISVIARDQGAPTPQSATAT 693
            ||.||:::| |..     |.|::|...|.::|.:|:|.|.|.: |...|.|.|.|:|..:....:
Human   490 NGYVTYSIAGPKA-----LPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVS 549

  Fly   694 VWLNVADVNDNDPQFYPRHYIYSLADDDDDIKLKKEVEKERILLHVTASDKDDGDNALIEYRLES 758
            ::|.:.::|||.|.|                   :||       :.|.|.:.|
Human   550 IFLQLRNLNDNQPMF-------------------EEV-------NCTGSIRQD------------ 576

  Fly   759 GGEGLFQLDARSGAISLRGDAPASMHWKPHYKLLVSARDAGQRRSQQDAIVEIVLKSKLEMLECG 823
                                      |.                         |.||.:.|
Human   577 --------------------------WP-------------------------VGKSIMTM---- 586

  Fly   824 QAQAGGYEFQMVEDHEQQRNSQPNREVGIVQVKSTNGKANSHIEYDIIQGDRAQNFRIDTRSGRI 888
                     ..::..|.|                       :::|:|:.|:..:.|.::..||.|
Human   587 ---------SAIDVDELQ-----------------------NLKYEIVSGNELEYFDLNHFSGVI 619

  Fly   889 TTARP---LDREEQANYRLTILASSSSSSSAAASSVSYGQCIVNIAIIDLNDNAPVFALDRESEP 950
            :..||   |...:..:|.|.|.||...:.::..:        :||.::              .:|
Human   620 SLKRPFINLTAGQPTSYSLKITASDGKNYASPTT--------LNITVV--------------KDP 662

  Fly   951 TISLPENAAVGQEIYLSRVRDRDAGVNSRISYSLTNNPNQQFRIGPVTGVLYLQRPIRAEPGSLI 1015
            ...:|...            |:                         ||||      .....:::
Human   663 HFEVPVTC------------DK-------------------------TGVL------TQFTKTIL 684

  Fly  1016 HVELMATDAGSPPLSSKLSLSVLIADVNDHTPVF-DHTSYETSLPETTKVNTRFFALAATDIDLG 1079
            |...:.....|....:.||    ...:|.:||.| ||......:.|:..:||....|||||.|.|
Human   685 HFIGLQNQESSDEEFTSLS----TYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAG 745

  Fly  1080 DNGRISYEIIEGNTERMFGV-FPDGYLFVRAPLDREERDYYALTVSCRDAGQPSRSSVVPVVIHV 1143
            .||::.|.|.:||.|..|.: ...|.|.|.||||.|..::|.|.|:..|.|.|.:||...:.::|
Human   746 FNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNV 810

  Fly  1144 IDENDNAPQFTNSTFTFSIPENAPADTFVGKLTAVDRDIGRNAELSFTLSSQTQDFTIDTRNGFI 1208
            .|.|||||:|....:..:|.|:....|.:.:||..|.|...|..:.:||.|.|:.|::....|.:
Human   811 KDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGEL 875

  Fly  1209 KTLRPFDREALVKVSRNAEASGEDGSLRGSMAGNYMLLEATVSDNGIPRLQDKVKVKVIVT--DV 1271
            ......|||:..:.....||       |...:..:.|...|               .:|:|  ||
Human   876 VVTGHLDRESEPRYILKVEA-------RDQPSKGHQLFSVT---------------DLIITLEDV 918

  Fly  1272 NDNAPEFLRAPYHVTISEGASEGTHITHVFTQDADEGLNGDVYYSLAKGNEAGQFNLDSATGQLS 1336
            |||:|:.:.....:.:.|....||.:|.:...|.|.|..|:|.|.|..|.. |.|.:|..||.|.
Human   919 NDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAH-GTFRVDLMTGALI 982

  Fly  1337 LGRRLDRESQEIHHLIVVAKDAALKHPLSSN--ASITIVVLDENDN--APEFTQSSSEVSVLETS 1397
            |.|.||.|.:..::|.:.|.|..  .||:..  ..:.::|||.|:|  .|.|.....:..|.|.|
Human   983 LERELDFERRAGYNLSLWASDGG--RPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENS 1045

  Fly  1398 PTGTELMRFRASDADQGVNSQVVFSISAGNRRDTFHIDSITGSLYLHKPLDYEDITSYTLNITAS 1462
            |:||:::...|.|.|.|::.::.:.:.||.....|.|:..||.:....|||.|..:.|.|.:.|.
Human  1046 PSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAV 1110

  Fly  1463 DCGTPSLSTTVLYNVLVVDDNDNPPIFPSTAIVRQIKEGIPLKTPIVTVTADDPDSGLNGKVSYA 1527
            |.|:..||:.....:.|.|.|||||..........|:|..|:.|.::.:.|.||||...||:::.
Human  1111 DRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFN 1175

  Fly  1528 ISKQEPQLPQGRHFG---INTETGVIHTLREIDRESIDTFRLTVVATDRAQPSERQLSTEKLVTV 1589
            |:       .|.:.|   |:..||::.|.:::|||:.|...|.|...|..:||.:  ||.::|..
Human  1176 IT-------SGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLK--STSRVVVG 1231

  Fly  1590 IVEDINDNAPVFV-SMNAAILPPKFS-TSKGSSTAVMQVHAKDADSSSNGLVTYEIVSGPQELFK 1652
            |: |:|||.|:|. .:....||.:.| .|.|   .|.::.|.|.|...||.|||.|....:|.|.
Human  1232 IL-DVNDNPPIFSHKLFNVRLPERLSPVSPG---PVYRLVASDLDEGLNGRVTYSIEDSDEEAFS 1292

  Fly  1653 LQRNTGII----TFTPGPQFKQEVRYQ-LTLKSTDEAVQSERRSSEVYITIIT-PGSGGSESSVP 1711
            :...||::    |||.|       .|. ||:|:||........|..::|..|. |    ..||:|
Human  1293 IDLVTGVVSSSSTFTAG-------EYNILTIKATDSGQPPLSASVRLHIEWIPWP----RPSSIP 1346

  Fly  1712 QFEQRSKLSGSVYENEPIGTSILTVTAHLASAEIEYFVTNVTATGSRGQVDRLFDIDAKLGILST 1776
            .....:..|.:|.|.:|:...:..::   .......|..|:    |.|..|..|||:...|.:..
Human  1347 LAFDETYYSFTVMETDPVNHMVGVIS---VEGRPGLFWFNI----SGGDKDMDFDIEKTTGSIVI 1404

  Fly  1777 AAELD-REAGPEEYEVEVYAIALGGQPRTSRTKVRV-TVLDKNDSPPQFLDTPFVYNVSEDLQIG 1839
            |..|| |........|||    ..|. ||..|:|.: .:.:.|...||||:|.:...|.:|...|
Human  1405 ARPLDTRRRSNYNLTVEV----TDGS-RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPG 1464

  Fly  1840 HTISTLRAHDPDTLGSVTFLLMDGHD----GKFLLEPSTGKLILNDTLDRET-KSKYELRIRVSD 1899
            ..:..::|.|.|...|:.:.:....|    ..|.|:||:|.|:....||..: .|::.|.:.|.|
Human  1465 VELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRD 1529

  Fly  1900 ---GVQYTEAYATIQVSDTNDNPPLFEDTVYSFDIPENAQRGYQVGQIVARDADLGQNAQLSYGV 1961
               .::....:.||.|.|.|.:||.|....|...:|:....|.::.|:.|.|||.|.||::.|.:
Human  1530 QEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSL 1594

  Fly  1962 VSDWANDVFSLNPQTGMLTLTARLDYEEVQHYILIVQAQDNGQPSLSTTITVYCNVLDLNDNAPI 2026
            :...:...|::|...|::||..:||......:.|.|:|:|.|.|......||..:|...:.:|||
Human  1595 LKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPI 1659

  Fly  2027 FDPMSYSSEVFENVPIATEVVTVSAKDIDSGNNGLIEYSITAGDVDSEFGIDS-NGTIRTRRNLD 2090
            |....|..|:.|::|:.:.::.|||.....     :.|.:..|:.|..|.::| :|.|.|::.||
Human  1660 FSKSEYFVEIPESIPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGLISTQKKLD 1719

  Fly  2091 REHRSTYTLTVTARDCADEFASFSELEETQLKLKYRSPRKYQQTRQEFLAHQKQQRLSSTVKVTI 2155
            .|..|:|.|.:...:.|..|                                      :.|.|.:
Human  1720 HEKISSYQLKIRGSNMAGAF--------------------------------------TDVMVVV 1746

  Fly  2156 LIKDVNDEVPVFISA------NETAIMENVAI--NTVVIAVKAVDNDEGRNGYIDYLMKEARDED 2212
            .|.|.||..|:|:.:      :|.|.:.::.:  |.....:.|.|:|:..|..:.|.:.|.....
Human  1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALK 1811

  Fly  2213 MGQSDPLPFSLNPTDGQLRVVDALDRELRSSYLLNITARDRGEP----PQSTESQLLIRILDEND 2273
            .       |.::|:.|.|.:|..:|.|...|:...:...|:|.|    |:  .:|::|.:.|.||
Human  1812 F-------FKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR--PAQVIIHVRDVND 1867

  Fly  2274 NSPVFDPKQYSASVAENASIGAMVLQVSATDVDEGANGRIRYSIVLGDQNHDFSISEDTGVVRVA 2338
            :.|.|..:.|..::......|..:|.|.|:|.|...|    |||..|:.:...:|...||.:.|.
Human  1868 SPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVN----YSIKTGNADEAVTIHPVTGSISVL 1928

  Fly  2339 KNLNYERLSRYSLTVRAEDCALENPAGDTAELTINILDINDNRPTFLDSPYLARVMENTVPPNGG 2403
             |..:..||| .||:||.|...:    |||.:.|::..:.|....|....|.|.|.||.......
Human  1929 -NPAFLGLSR-KLTIRASDGLYQ----DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL 1987

  Fly  2404 YVLTVNAYDADTPPLNSQVRYFLKEGDSDLFRINASSGDIALLK----PLDREQQSEYTLTLVAM 2464
            .:|     .|....||..:.|||..| :|:|.:..|:|   :|:    ..|||||..:.|.:...
Human  1988 VIL-----GAQGNHLNDTLSYFLLNG-TDMFHMVQSAG---VLQTRGVAFDREQQDTHELAVEVR 2043

  Fly  2465 DTGSPPLTGTGIVRVEVQDINDNDPVFELQSYHATVRENLPSGTHVLTPRATDKDEGLNAKLRFN 2529
            |..:|.....|:|||.::|:|||.|.|:...|:..:::....|..:....|||:|.|.|..:.:.
Human  2044 DNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYE 2108

  Fly  2530 LLGEHMHRFHIDSETGEISTATTLDREETSVYHLTLMAQDSSITEPRASSVNLTISVSDVNDNIP 2594
            ...::.: |.||...|:||.....|.:..:.|||.::|:|.. |....|...:.::|.  |.:.|
Human  2109 FAEDYTY-FRIDPYLGDISLKKPFDYQALNKYHLKVIARDGG-TPSLQSEEEVLVTVR--NKSNP 2169

  Fly  2595 KFDSTTYNVAVPERISKGEFVFGARALDLDDGENAVVHYTISGRDQHYFDINTKTGV--VSTKLE 2657
            .|.|..|.|.|||.|:....:...:|.. .:|.. :::..:.......|..:.||||  |:..|:
Human  2170 LFQSPYYKVRVPENITLYTPILHTQARS-PEGLR-LIYNIVEEEPLMLFTTDFKTGVLTVTGPLD 2232

  Fly  2658 LKTKTKSHDDLTYTIVISAMDQGEQSLSSKAELTVILRPPELF---PTFAYMANSHFAMSEDVRP 2719
            .::|||      :...:.|.|   .:|.|.:|.||.:...::.   |||:.:..: .::||.:..
Human  2233 YESKTK------HVFTVRATD---TALGSFSEATVEVLVEDVNDNPPTFSQLVYT-TSISEGLPA 2287

  Fly  2720 GKMITKVSATSPKKGLVGKIRYAIA--GGIMGDSLRVDPNSGLLSVGQDGLDYELTHLYEIWIEA 2782
            ...:.::.|:....|....:.|.|.  |..:....:::.::|.:|..|: ||||....:.:.:.|
Human  2288 QTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE-LDYEAQQHFHVKVRA 2351

  Fly  2783 ADGDTPSLRSVTLITLNVTDANDNAPVMEQLIYNAEVLEEESPPQLIAVVKASDRDSGDNGNVIY 2847
            .|...|.|...||:.:||:|.|||.|...|..|.|.|.|..:...|:..|:|.|.||.|...:.|
Human  2352 MDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEY 2416

  Fly  2848 R-LQNDFDGTFEITESGEIYTRMRLDREEI-GDYAFVVEAVDQGVPHMTGTASVLLHLLDKNDNP 2910
            . |..:.|..|.|..|..|.:...|.::.: ..|...|.|.| ||  ...|..|.::..:.|...
Human  2417 LILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASD-GV--FRATVPVYINTTNANKYS 2478

  Fly  2911 PKFTR-LFSLNVTENAEIGSFVIRVTSSDLDLGANANASYS-FSENPGEKFRIEPQSGNITVAGH 2973
            |:|.: |:...:.|||.:|:.||.:.:.|.|.|......|: .::...|||.|.| :|.|.....
Human  2479 PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQK 2542

  Fly  2974 LDREQQDEYI--LKVVASDGAWR-AETPITITIQDQNDNAPEFEHSFYSFSFPELQQSIALVGQI 3035
            ||||...|.:  :||:|.||..| |...:.|.:.|:|||.|:|:.|.|:.|........:.|.|:
Human  2543 LDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQV 2607

  Fly  3036 IATDRDKQGPNSVISYSLQQP---SPMFSIDPATGEVFSKKAVRFKHSQYVRSPENMYALTVLAT 3097
            :|.|.| :|.|:.::||:...   ..:..|:|.||.|..|.::       |..........:.|.
Human  2608 LAYDAD-EGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSL-------VGLENQTLDFFIKAQ 2664

  Fly  3098 DNGKPPLYSECLVNINIVDAHNNPPKFEQAEYLAPLPQDAVRGQRIVRVHANDKQDLGTNEMDYS 3162
            |.|.|...|...|.:.:|....:.|||.:..|....|:|...|..|..|.|...||    .:.||
Human  2665 DGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYS 2725

  Fly  3163 LM-----TFNLSSIFSVGRHDGWITLVKPIQVPPNTRYELVVRA-----TDRGVPPQSDETRVVI 3217
            |:     ..|...:||:....|.|.:.||:.......|::.|.|     ||           ||.
Human  2726 LVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTD-----------VVS 2779

  Fly  3218 VVT-----GE-NMDTPRFSVNSYQVIVPENEPVGSTILTVGATDDDTGPNGMLRYSIS---GGNE 3273
            :|:     |: |.:.|.|..:.|:.::.||.|||::::.|.|.|.|||.:|.:.|.:|   |.|.
Human  2780 LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNV 2844

  Fly  3274 RQDFSVDERTGGIVIQQQLDYDLIQEYHLNITVQDLGYH-PLSSVAMLTIILTDVNDNPPVFNHK 3337
            .:.|::|..:|.|...|:||.:..|.||.::...|.|.. .|||.|::.:.:||.|||.|.|..:
Human  2845 HELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASE 2909

  Fly  3338 EYH-------------------------------CYIPENKPVGTF------------------- 3352
            ||.                               |||.|..|:|.|
Human  2910 EYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDR 2974

  Fly  3353 -------------------------------------------------VFQAH------AADKD 3362
                                                             ||..|      |.|.|
Human  2975 EHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLD 3039

  Fly  3363 SPKNAIIHYAFLPSGPDRHFFIMNQSNGTISSAVSFDYEERRIYTLQIKAKNPDSSMESYANLYV 3427
            :..||.|.|:.  .||..|.|.::...|.:::..:.|.|.:.::.|..||.: .......|::.:
Human  3040 TDTNAQITYSL--HGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD-GGGRSCQADITL 3101

  Fly  3428 HVLGVNEFYPQFLQPVFHFDVSETSAVGTRVGAVQATDKDSGEDGRVYYLL-------------- 3478
            ||..||:..|:|........|.:.:.|.|.|..|.|.|.|.|.:.:|.|.|
Human  3102 HVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATT 3166

  Fly  3479 ----------------------------------------------------------------- 3478

Human  3167 GVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDA 3231

  Fly  3479 -----------------------VGSSNDKG-FRIDTNTGLIYVARHLDRETQNRVVLTVMAKNY 3519
                                   |.|.|::| ||:|..||::||...||.||..:..|::.....
Human  3232 PPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRK 3296

  Fly  3520 GSIRGNDTDEAQVIISIQDGND-PPEFIKHYYTSTISEAAPVGTKVTTVKAIDKDVRTQNNQFSY 3583
            .|  .:.:|...|:::|.|.|: .|:|.:..|::.:.|.|.||..:.||.|.|:| ...|:..:|
Human  3297 SS--SSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDED-GPLNSDITY 3358

  Fly  3584 SIINGNLKQSFKIDVQTGEISTASRLDREETSTYNLVIGAIDTGLPPQTGSATVHIELEDVNDNG 3648
            |:|.||....|.|..:.||:..|..||||:.|:|:|.:.|.|:|.||......:.|::.|||||.
Human  3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNP 3423

  Fly  3649 PTFTPEGLNGYISENEPAGTSIMTLIASDPDLPRNGGPFTYQLIGGKHKSWLSVDRNSGVVRSTT 3713
            |.|.....:..:.||.|.|:.::.||.||||.|.||.|:::::..|.:.|...|..:..:| :..
Human  3424 PRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLV-TAE 3487

  Fly  3714 SFDREMTPILEAIIEVEDSGKPKQKSQHLLTITVLDQNDNPSTTRSLHIAVSL----FNGDLPSN 3774
            ...|......:..|:..|||.|...|...:.:.|.:|:....:...|.|.:::    |.|.:...
Human  3488 GLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGK 3552

  Fly  3775 VKLADVRPNDIDIVGDYRCRLQKNPAQSQLQLAIPRACDLITTSHTTPIASVFSYTGNDGK---- 3835
            :...|..|.|         .|..:.|:.:                  .:...||....|||
Human  3553 IHATDRDPQD---------TLTYSLAEEE------------------TLGRHFSVGAPDGKIIAA 3590

  Fly  3836 ----HGDVSSKVSVAFQSF-------------NNETLANSVSIMVRNMTAYHFLANHYRPILEMI 3883
                .|..|..|:|:..:|             ..|.|..::.:....:|....:::|:|.:...:
Human  3591 QGLPRGHYSFNVTVSDGTFTTTAGVHVYVWHVGQEALQQAMWMGFYQLTPEELVSDHWRNLQRFL 3655

  Fly  3884 KSRMS-NEDEVILYSL--------------LEGGSGNSTNLQLLMAVRLAKTSYQQPKYLIERLR 3933
            ..::. ....:.|.||              .||.||.....|.|.::            :....:
Human  3656 SHKLDIKRANIHLASLQPAEAVAGVDVLLVFEGHSGTFYEFQELASI------------ITHSAK 3708

  Fly  3934 EKRSAFSELLQKEVIVGYEPCSEPDVCENGGVCSATMRLLDAHSFVIQDSPALVLSGPRVVHDYS 3998
            |...:..  :|....:...||..| .|: |.:|..|:. ||........:..|.:..||.....|
Human  3709 EMEHSVG--VQMRSAMPMVPCQGP-TCQ-GQICHNTVH-LDPKVGPTYSTARLSILTPRHHLQRS 3768

  Fly  3999 CQC---TSGFSGEQCSRRQDPCLPNPCHSQVQCR-------------------RLGS-----DFQ 4036
            |.|   .:.|||:...|.:.|...| .|.....:                   :|.|     ::.
Human  3769 CSCNGTATRFSGQSYVRYRAPAARN-WHIHFYLKTLQPQAILLFTNETASVSLKLASGVPQLEYH 3832

  Fly  4037 CM-------------------------------------------CPANRDGKHCEKE------- 4051
            |:                                           .|.|..|...|:.
Human  3833 CLGGFYGNLSSQRHVNDHEWHSILVEEMDASIRLMVDSMGNTSLVVPENCRGLRPERHLLLGGLI 3897

  Fly  4052 -------------------------------------------------RSDVCYSKPCRNGGSC 4067
                                                             .||.|....|.|||.|
Human  3898 LLHSSSNVSQGFEGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQCCLHSDYCSQNTCLNGGKC 3962

  Fly  4068 QRSPDGSSYFCLCRPGFRGNQCESVSDSCRPNPCLHGGLCVSLKPGYKCNCTPGRYGRHCE---- 4128
            ..: .|:.|.|.|.|.|.|..||...::|...|||.||.|:....|..|||.....|..||
Human  3963 SWT-HGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEAR 4026

  Fly  4129 --------------RFSYGFQPLSYMTFPALDVTTNDISIVF 4156
                          |..:|.|.|..:|.....:..:.:.::|
Human  4027 GCSEGHCLVTPEIQRGDWGQQELLIITVAVAFIIISTVGLLF 4068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ft	NP_477497.1	Cadherin_repeat	71..152	CDD:206637
		Cadherin_repeat	163..266	CDD:206637	26/76 (34%)
		Cadherin_repeat	275..378	CDD:206637	22/102 (22%)
		Cadherin_repeat	393..490	CDD:206637	23/103 (22%)
		Cadherin_repeat	498..594	CDD:206637	27/95 (28%)
		Cadherin_repeat	603..704	CDD:206637	36/102 (35%)
		Cadherin_repeat	735..814	CDD:206637	5/78 (6%)
		Cadherin	843..>907	CDD:278457	12/66 (18%)
		Cadherin	950..1026	CDD:278457	8/75 (11%)
		Cadherin_repeat	1053..1149	CDD:206637	37/96 (39%)
		Cadherin_repeat	1157..1274	CDD:206637	27/118 (23%)
		Cadherin_repeat	1282..1380	CDD:206637	32/99 (32%)
		Cadherin_repeat	1390..1485	CDD:206637	30/94 (32%)
		Cadherin_repeat	1497..1597	CDD:206637	33/102 (32%)
		Cadherin_repeat	1621..1699	CDD:206637	26/82 (32%)
		Cadherin_repeat	1720..1818	CDD:206637	25/99 (25%)
		Cadherin_repeat	1827..1918	CDD:206637	25/98 (26%)
		Cadherin_repeat	1926..2023	CDD:206637	28/96 (29%)
		Cadherin_repeat	2031..2162	CDD:206637	27/131 (21%)
		Cadherin_repeat	2172..2274	CDD:206637	25/107 (23%)
		Cadherin_repeat	2282..2380	CDD:206637	29/97 (30%)
		Cadherin_repeat	2388..2487	CDD:206637	32/102 (31%)
		Cadherin_repeat	2495..2592	CDD:206637	24/96 (25%)
		Cadherin_repeat	2600..2694	CDD:206637	25/95 (26%)
		Cadherin_repeat	2710..2806	CDD:206637	24/97 (25%)
		Cadherin_repeat	2814..2909	CDD:206637	28/96 (29%)
		Cadherin_repeat	2917..3009	CDD:206637	32/95 (34%)
		Cadherin	3018..3114	CDD:278457	24/98 (24%)
		Cadherin	3129..3220	CDD:278457	26/100 (26%)
		Cadherin_repeat	3233..3330	CDD:206637	36/100 (36%)
		Cadherin_repeat	3338..3434	CDD:206637	33/200 (17%)
		Cadherin_repeat	3443..3541	CDD:206637	33/200 (17%)
		Cadherin_repeat	3550..3647	CDD:206637	37/96 (39%)
		Cadherin_repeat	3657..3753	CDD:206637	27/95 (28%)
		EGF	4017..4047	CDD:278437	8/96 (8%)
		EGF_CA	4056..4090	CDD:238011	13/33 (39%)
		EGF_CA	4094..4128	CDD:238011	12/33 (36%)
		Laminin_G_1	4156..4306	CDD:278483	1/1 (100%)
		LamG	4428..4543	CDD:238058
FAT2	NP_001438.1	Cadherin_repeat	462..560	CDD:206637	36/102 (35%)
		Cadherin_repeat	570..659	CDD:206637	27/195 (14%)
		Cadherin_repeat	719..816	CDD:206637	37/96 (39%)
		Cadherin_repeat	825..921	CDD:206637	27/117 (23%)
		Cadherin_repeat	931..1026	CDD:206637	32/97 (33%)
		Cadherin_repeat	1038..1133	CDD:206637	30/94 (32%)
		Cadherin_repeat	1141..1238	CDD:206637	33/106 (31%)
		Cadherin_repeat	1247..1335	CDD:206637	30/97 (31%)
		Cadherin_repeat	1354..1444	CDD:206637	26/101 (26%)
		Cadherin_repeat	1453..1551	CDD:206637	25/97 (26%)
		Cadherin_repeat	1559..1650	CDD:206637	27/90 (30%)
		Cadherin_repeat	1664..1754	CDD:206637	28/132 (21%)
		Cadherin_repeat	1762..1867	CDD:206637	24/113 (21%)
		Cadherin_repeat	1887..1963	CDD:206637	28/85 (33%)
		Cadherin_repeat	<1998..2066	CDD:206637	24/71 (34%)
		Cadherin_repeat	2074..2163	CDD:206637	22/90 (24%)
		Cadherin_repeat	2176..2268	CDD:206637	25/102 (25%)
		Cadherin_repeat	2276..2375	CDD:206637	24/100 (24%)
		Cadherin_repeat	2383..2475	CDD:206637	27/94 (29%)
		Cadherin_repeat	2486..2581	CDD:206637	32/95 (34%)
		Cadherin_repeat	2589..2682	CDD:206637	24/100 (24%)
		Cadherin_repeat	2696..2793	CDD:206637	29/111 (26%)
		Cadherin_repeat	2801..2902	CDD:206637	36/100 (36%)
		Cadherin_repeat	2910..3007	CDD:206637	9/96 (9%)
		Cadherin_repeat	3016..3109	CDD:206637	25/95 (26%)
		Cadherin_repeat	3120..3209	CDD:206637	12/88 (14%)
		Cadherin_repeat	3224..3317	CDD:206637	22/94 (23%)
		Cadherin_repeat	3325..3422	CDD:206637	37/97 (38%)
		Cadherin_repeat	3431..3522	CDD:206637	25/91 (27%)
		Cadherin_repeat	3535..3619	CDD:206637	18/110 (16%)
		Laminin_G_2	3800..3921	CDD:280389	7/120 (6%)
		EGF_CA	3949..3984	CDD:238011	14/35 (40%)
		Cadherin_repeat	37..143	CDD:206637	25/75 (33%)
		Cadherin_repeat	152..247	CDD:206637	22/104 (21%)
		Cadherin_repeat	366..454	CDD:206637	28/96 (29%)
		EGF	3990..4020	CDD:278437	12/29 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100175
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710