Protein Alignment ft and Pcdh8

DIOPT Version :10

• Sequence 1: NP_477497.1
• Gene: ft / 33627
• FlyBaseID: FBgn0001075
• Length: 5147
• Species: Drosophila melanogaster
• Sequence 2: NP_067518.2
• Gene: Pcdh8 / 18530
• MGIID: 1306800
• Length: 1070
• Species: Mus musculus
• Alignment Length: 710
• Identity: 213/710 - (30%)
• Similarity: 319/710 - (44%)
• Gaps: 107/710 - (15%)

  Fly    61 QSRAVDTSADFEVLEGQPRGTTVGFI----------PTKPKFSYRFNEP---PREFTLDPVTGEV 112
            ||:.|..|. ||  |..| ||.:|.:          .|..:...:||..   .||.......|:.
Mouse    28 QSKTVRYST-FE--EDAP-GTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDA 88

  Fly   113 KTNVVLDREGMRD-------HYDLVVLSSQPTYPIEVRIKVLDVNDNSPEFPEPSIAISFSESAT 170
            .    ||||.:..       .:|:|..|.:....:.|.::|.||||::|.||...|.:..||||.
Mouse    89 G----LDRERLCGPSPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSESAP 149

  Fly   171 SGTRLLLDAATDADVGENGVTDQYEIVAGNVDNKFR--LVTTANPSGDTSYLHLETTGNLDRESR 233
            .|||:.|:...|.|||.||:   ..:......:.||  |.|.|:.:.....:.|:   .|||||:
Mouse   150 VGTRIPLEVPVDEDVGANGL---QSVRLAEPHSPFRVELQTRADGAQCADLVLLQ---ELDRESQ 208

  Fly   234 GSYQLNISARDGGSPPRFGYLQVNVTILDVNDNPPIFDHSDY-NVSLNETALPGTPVVTVMASDN 297
            .||.|.:.|:|||.|||.....::|.:||.||:.|.|..... .|.|.|.|..|:.::.:.|:|.
Mouse   209 ASYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADP 273

  Fly   298 DLGDNSKITYYLA-----ETEHQFTVNPETGVISTTERVNCPQQTNVKSSASQKSCVFTVFARDH 357
            |.|.|..:.:...     |..|.|.::|.:|.::...:|:..:|...:         ..|.|:|.
Mouse   274 DEGPNGDVVFTFGARTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYE---------LDVRAQDR 329

  Fly   358 GSPRQDGRTYVTVNLLDTNDHDPIISFRFFPDGGKVAT--------------------------- 395
            |...:.....|.|.:.|.||:.|.||.......|..||
Mouse   330 GPGPRTATCKVIVRIRDVNDNAPEISITPLAAPGAPATSPFAAAAAAAALGGADAASSTGSGTQE 394

  Fly   396 ------VDENAVNGTVVAAVAVKDSDSGLNGRTSVRIVSGNELGHFRLEEA-ADLHIVRVNGVLD 453
                  |.|.|...::||.|:..|.|||.||:....:. |:|  ||||:.| |..::|.....||
Mouse   395 AGITSLVPEGAARESLVALVSTSDRDSGANGQVRCALY-GHE--HFRLQPAYAGSYLVVTAASLD 456

  Fly   454 REEIGKYNLTVVAMDQGTPARTTTAHLIIDVNDVNDHEPVFEKSEYSAVLSELAPTGSFVASITA 518
            ||.|.:||||:||.|:|||...|.....:.|.|.||:.|:|.|..|...:.|..|.|:::|::.|
Mouse   457 RERIAEYNLTLVAEDRGTPPLRTVRPYTVRVGDENDNAPIFTKPVYEVSVRENNPPGAYLATVAA 521

  Fly   519 TDEDTGVNAQVHYDIL------SGNELK-WFSMDPLTGLIVTTGPLDREIRDTVELSISARDGGP 576
            .|.|.|.|.||.|.::      ||..:. :.|:||.||.|......|.|....:::.:.|.|||
Mouse   522 RDPDVGRNGQVTYRLVEAEVGRSGEAVSTYVSVDPATGAIYALRSFDYETLRQLDVRVQASDGG- 585

  Fly   577 NPKFAYTQL-KVIILDENDEAPQF-----SQREQNVTLGEDAPPQTIVALMTATDHDQGTNGSVT 635
            :|:.:...| :|.:||:||.:|..     :.....|.:...:...|.||.:.|.|.|:|.||.:.
Mouse   586 SPQLSSNALVQVRVLDQNDHSPILVHPAPANGSLEVAVPGRSTKDTAVARIQARDADEGANGELA 650

  Fly   636 FALAPSVERLYPLQFALDALTGQLTTRRPLDREKMSQ-YEISVIARDQGAPTPQSATATV 694
            |.|.....|   ..|::...||::.....|.:|...: ::..::..|.|.| |.:.||||
Mouse   651 FDLLQQEPR---EAFSIGRHTGEIMLTGDLSQEPPGRVFKALLVISDGGRP-PLTTTATV 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ft	NP_477497.1	Cadherin_repeat	71..152	CDD:206637	25/100 (25%)
		Cadherin_repeat	163..266	CDD:206637	39/104 (38%)
		Cadherin_repeat	275..378	CDD:206637	25/108 (23%)
		Cadherin_repeat	393..490	CDD:206637	42/130 (32%)
		Cadherin_repeat	498..594	CDD:206637	32/103 (31%)
		Cadherin_repeat	603..704	CDD:206637	26/93 (28%)
		Cadherin_repeat	735..814	CDD:206637
		Cadherin	843..>907	CDD:394985
		Cadherin	950..1026	CDD:394985
		Cadherin_repeat	1053..1149	CDD:206637
		Cadherin_repeat	1157..1274	CDD:206637
		Cadherin_repeat	1282..1380	CDD:206637
		Cadherin_repeat	1390..1485	CDD:206637
		Cadherin_repeat	1497..1597	CDD:206637
		Cadherin_repeat	1621..1699	CDD:206637
		Cadherin_repeat	1720..1818	CDD:206637
		Cadherin_repeat	1827..1918	CDD:206637
		Cadherin_repeat	1926..2023	CDD:206637
		Cadherin_repeat	2031..2162	CDD:206637
		Cadherin_repeat	2172..2274	CDD:206637
		Cadherin_repeat	2282..2380	CDD:206637
		Cadherin_repeat	2388..2487	CDD:206637
		Cadherin_repeat	2495..2592	CDD:206637
		Cadherin_repeat	2600..2694	CDD:206637
		Cadherin_repeat	2710..2806	CDD:206637
		Cadherin_repeat	2814..2909	CDD:206637
		Cadherin_repeat	2917..3009	CDD:206637
		Cadherin	3018..3114	CDD:394985
		Cadherin	3129..3220	CDD:394985
		Cadherin_repeat	3233..3330	CDD:206637
		Cadherin_repeat	3338..3434	CDD:206637
		Cadherin_repeat	3443..3541	CDD:206637
		Cadherin_repeat	3550..3647	CDD:206637
		Cadherin_repeat	3657..3753	CDD:206637
		EGF	4017..4047	CDD:394967
		EGF_CA	4056..4090	CDD:238011
		EGF_CA	4094..4128	CDD:238011
		Laminin_G_1	4156..4306	CDD:395008
		LamG	4428..4543	CDD:238058
Pcdh8	NP_067518.2	Cadherin_2	31..109	CDD:462413	20/85 (24%)
		Cadherin_repeat	139..241	CDD:206637	40/107 (37%)
		Cadherin_repeat	252..350	CDD:206637	25/106 (24%)
		Cadherin_repeat	401..493	CDD:206637	40/94 (43%)
		Cadherin_repeat	501..605	CDD:206637	33/104 (32%)
		Cadherin_repeat	618..711	CDD:206637	26/93 (28%)