DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ft and Cdhr1

DIOPT Version :9

Sequence 1:	NP_477497.1	Gene:	ft / 33627	FlyBaseID:	FBgn0001075	Length:	5147	Species:	Drosophila melanogaster
Sequence 2:	NP_570948.1	Gene:	Cdhr1 / 170677	MGIID:	2157782	Length:	859	Species:	Mus musculus

Alignment Length:	755	Identity:	202/755 - (26%)
Similarity:	318/755 - (42%)	Gaps:	149/755 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1795 AIALGGQPRTSRTKVRVTVLDKNDSPPQFLDTPF--------VYNVSEDLQIGHTISTLRAHDPD 1851
            |:.||        .:|:.:...|.: |.|.|...        ::::.||..:|..:.||...||:
Mouse     8 ALVLG--------LLRIYLAQANFA-PHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPE 63

  Fly  1852 ------------TLGSVTFLLMDGHDGKFLLEPSTGKLILNDTLDRETKSKYELRIRVSDGVQYT 1904
                        :..||           |.::|:.|.:.|.:.||||.:.:.|..|.:|||:...
Mouse    64 GDPISYHISFDPSTRSV-----------FSVDPNFGNITLVEELDREREDEIEAIISISDGLNLV 117

  Fly  1905 EAYATIQVSDTNDNPPLFEDTVYSFDIPENAQRGYQVGQIVARDADLGQNAQLSYGVVSDWANDV 1969
            .....|.|:|.||..|.|....|...:|||...|..:.::.|.|.|.|....::|. :.:..:..
Mouse   118 AEKVVILVTDANDEAPRFIQEPYIIRVPENIPAGSSIFKVQAEDKDTGSGGSVTYS-LQNLHSSK 181

  Fly  1970 FSLNPQTGMLTLT--ARLDYEEVQ-HYILIVQAQDNG------QPSLSTTITVYCNVLDLNDNAP 2025
            ||::..:|:|.|.  |.||||:.: |||.:: |:|.|      ....|.|.||..||.|:.|.||
Mouse   182 FSMDRHSGVLRLQAGATLDYEKSRAHYITVI-AKDGGGRLRGADMVFSATTTVTINVEDVQDTAP 245

  Fly  2026 IFDPMSYSSEVFENVPIATEVVTVSAKDIDSGNNGLIEYSITAGDVDSEFGI-DSNGTIRTRRNL 2089
            ||....|...|:|:....:||:||.|.|.|.|....|.|.: ..:.|..|.| :::|.|...::.
Mouse   246 IFVGTPYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRL-LNESDGIFEINETSGAISVLQSP 309

  Fly  2090 DREHRSTYTLTVTARDCADEFASFSELEETQLKLKYRSPRKYQQTRQEFLAHQKQQRLSSTVKVT 2154
            ....|..|.|.|...:                   ..||              ......:||.||
Mouse   310 ALLRREVYELHVQVTE-------------------VNSP--------------GSPAAQATVPVT 341

  Fly  2155 ILIKDVNDEVPVFISAN------ETAIMENVAINTVVIAVKAVDNDEGRNGYIDYLMKEARDEDM 2213
            |.|.|:|:..|.|...:      |.::.|:.....::..:|...|                |.|.
Mouse   342 IRIVDLNNHPPTFYGESGPQNKFELSMFEHPPQGEILRGLKITVN----------------DSDQ 390

  Fly  2214 GQSDPLPFSLNPTDGQLRVVD-----------------ALDRELRSSYLLNITARDRGEPPQ-ST 2260
            |.:......|....|..|||.                 |:|.|........:.|.:...|.: |:
Mouse   391 GANAKFNLRLVGPGGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKLLTFKLLAIEVNTPEKFSS 455

  Fly  2261 ESQLLIRILDENDNSPVFDPKQYSASVAENASIGAMVLQVSATDVDEGANGRIRYSIVLGDQNHD 2325
            .:.::|::||.|||.|.|....|.|.:.|||..|:.|:.|:|.|.|.|..|::.||| .|..:..
Mouse   456 TADIVIQLLDTNDNVPKFTSHYYIARIPENAPGGSNVVAVTAVDPDTGPWGKVHYSI-YGTGSDL 519

  Fly  2326 FSISEDTGVVRVA--KNLNYERLSRYSLTVRAEDCALENPAGDTAELTINILDINDNRPTFLDSP 2388
            |.|...||::...  .:|:.|..|||:..|:|||.   :.....||:.:.:||:||:.|.|:.|
Mouse   520 FLIHPSTGLIYTQPWASLDAEGTSRYNFYVKAEDM---DGRYSLAEVFVTLLDVNDHYPQFVQS- 580

  Fly  2389 YLARVMENTVPPNGGYVLTVNAYDADTPPLNSQVRYFLKEGDS-DLFRINASSGDIAL------L 2446
                |.|.|:..  |..|.:.|.|.|....|:.|.|.:...:. ::|.|:|.:|:|.|      |
Mouse   581 ----VQEKTMVL--GTPLKIEATDQDAEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSIRSL 639

  Fly  2447 KPLDREQQS---EYTLTLVAMDTGSPPLTGTGIVRVEVQD 2483
            :.|.....|   .::|.:.|.|.|||..:.|.::::::.|
Mouse   640 EALHNITPSGDYSWSLQVQAKDRGSPSFSTTALLKIDITD 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ft	NP_477497.1	Cadherin_repeat	71..152	CDD:206637
		Cadherin_repeat	163..266	CDD:206637
		Cadherin_repeat	275..378	CDD:206637
		Cadherin_repeat	393..490	CDD:206637
		Cadherin_repeat	498..594	CDD:206637
		Cadherin_repeat	603..704	CDD:206637
		Cadherin_repeat	735..814	CDD:206637
		Cadherin	843..>907	CDD:278457
		Cadherin	950..1026	CDD:278457
		Cadherin_repeat	1053..1149	CDD:206637
		Cadherin_repeat	1157..1274	CDD:206637
		Cadherin_repeat	1282..1380	CDD:206637
		Cadherin_repeat	1390..1485	CDD:206637
		Cadherin_repeat	1497..1597	CDD:206637
		Cadherin_repeat	1621..1699	CDD:206637
		Cadherin_repeat	1720..1818	CDD:206637	4/22 (18%)
		Cadherin_repeat	1827..1918	CDD:206637	26/110 (24%)
		Cadherin_repeat	1926..2023	CDD:206637	33/105 (31%)
		Cadherin_repeat	2031..2162	CDD:206637	31/131 (24%)
		Cadherin_repeat	2172..2274	CDD:206637	22/119 (18%)
		Cadherin_repeat	2282..2380	CDD:206637	35/99 (35%)
		Cadherin_repeat	2388..2487	CDD:206637	28/106 (26%)
		Cadherin_repeat	2495..2592	CDD:206637
		Cadherin_repeat	2600..2694	CDD:206637
		Cadherin_repeat	2710..2806	CDD:206637
		Cadherin_repeat	2814..2909	CDD:206637
		Cadherin_repeat	2917..3009	CDD:206637
		Cadherin	3018..3114	CDD:278457
		Cadherin	3129..3220	CDD:278457
		Cadherin_repeat	3233..3330	CDD:206637
		Cadherin_repeat	3338..3434	CDD:206637
		Cadherin_repeat	3443..3541	CDD:206637
		Cadherin_repeat	3550..3647	CDD:206637
		Cadherin_repeat	3657..3753	CDD:206637
		EGF	4017..4047	CDD:278437
		EGF_CA	4056..4090	CDD:238011
		EGF_CA	4094..4128	CDD:238011
		Laminin_G_1	4156..4306	CDD:278483
		LamG	4428..4543	CDD:238058
Cdhr1	NP_570948.1	Cadherin_repeat	42..130	CDD:206637	25/98 (26%)
		Cadherin_repeat	139..242	CDD:206637	33/104 (32%)
		Cadherin_repeat	251..350	CDD:206637	32/132 (24%)
		Cadherin_repeat	364..469	CDD:206637	22/120 (18%)
		Cadherin_repeat	478..573	CDD:206637	35/98 (36%)
		Cadherin_repeat	580..679	CDD:206637	28/105 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910