DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ft and Pcdh12

DIOPT Version :10

Sequence 1:NP_477497.1 Gene:ft / 33627 FlyBaseID:FBgn0001075 Length:5147 Species:Drosophila melanogaster
Sequence 2:NP_446396.1 Gene:Pcdh12 / 116808 RGDID:619917 Length:1179 Species:Rattus norvegicus


Alignment Length:1545 Identity:343/1545 - (22%)
Similarity:524/1545 - (33%) Gaps:559/1545 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   392 KVATVD------ENAVNGTVVAAVAVKDSDSGLNGRTSVRIVSGNELGHFRLEEAADLHIVRVNG 450
            :||||.      |...:|||:..::   .:.|:..|   |..:|:.....:|.:|..:.:...:|
  Rat    25 EVATVTVKFQVAEEVPSGTVIGKLS---QEPGVEER---RGKAGDAFQILQLPQALPIQMNSEDG 83

  Fly   451 V------LDREEI-GKYNLTVVAMDQGTPARTTTAHLIIDVNDVNDHEPVFEKSEYSAVLSELAP 508
            :      ||||:: .:.:..:|:.|......:...|:.|.|.|:|||:|.|.|.|....:||.|.
  Rat    84 LLNTSSRLDREKLCRQQDPCLVSFDVLATGASALIHVEIQVLDINDHQPQFPKDEQELEISESAS 148

  Fly   509 TGSFVASITATDEDTGVNAQVHYDILSGNELKWFSMDPLTG-------LIVTTGPLDREIRDTVE 566
            ..:.:....|.|:|||.|:...|. ||.:|  .|::|.:.|       .:|....||||:....:
  Rat   149 LHTRIPLDRALDQDTGPNSLYSYS-LSPSE--HFALDVIVGPDETKHAELVVVKELDREVHSYFD 210

  Fly   567 LSISARDGGPNPKFAYTQLKVIILDENDEAPQFSQREQNVTLGEDAPPQTIVALMTATDHDQGTN 631
            |.::|.|.|..||...:.:||.:||.||.:|.|::....:.:.||..|.|::..:||||.|||.|
  Rat   211 LVLTAYDNGNPPKSGTSVVKVNVLDSNDNSPVFAESSLALEIPEDTAPGTLLINLTATDPDQGPN 275

  Fly   632 GSVTFALAPSVERLYPLQFALDALTGQLTTRRPLDREKMSQYEISVIARDQGAPTPQSATATVWL 696
            |.|.|.....|.......|.:||.|||:...:|||.||...||:.|.|||.| |........|.:
  Rat   276 GEVEFFFGKHVSPEVMNTFGIDAKTGQIVLLQPLDYEKNPAYEVDVQARDLG-PNSIPGHCKVLI 339

  Fly   697 NVADVNDNDPQFYPRHYIY----SLADDDDDIKLKKEVEKERILLHVTASDKDDGDNALIEYRLE 757
            .|.|||||.|..   |..:    ||..:|        :.::..:..|:|:|.|.|:|.|:     
  Rat   340 KVLDVNDNAPSI---HITWASQMSLVSED--------LPRDSFIALVSANDLDSGNNGLV----- 388

  Fly   758 SGGEGLFQLDARSGAISLRGDAPASMHWKPHYKLLVSARDAGQRRSQQDAIVEIVLKSKLEMLEC 822
                                                                             
  Rat   389 ----------------------------------------------------------------- 388

  Fly   823 GQAQAGGYEFQMVEDHEQQRNSQPNREVGIVQVKSTNGKANSHIEYDIIQGDRAQNFRIDTRSGR 887
                                |...|:|:|..::|.|||  |:::                     
  Rat   389 --------------------NCWLNQELGHFRLKRTNG--NTYM--------------------- 410

  Fly   888 ITTARPLDREEQANYRLTILASSSSSSSAAASSVSYGQCIVNIAIIDLNDNAPVFALDRESEPTI 952
            :.|:..||||:...|.||:.|.                                           
  Rat   411 LLTSAMLDREQWPTYTLTVFAQ------------------------------------------- 432

  Fly   953 SLPENAAVGQEIYLSRVRDRDAGVNSRISYSLTNNPNQQFRIGPVTGVLYLQRPIRAEPGSLIHV 1017
                                                                             
  Rat   433 ----------------------------------------------------------------- 432

  Fly  1018 ELMATDAGSPPLSSKLSLSVLIADVNDHTPVFDHTSYETSLPETTKVNTRFFALAATDIDLGDNG 1082
                 |.|...||::..|.:.::||||:.|||:.:.||.|..|....:.....|.|.|.|||.||
  Rat   433 -----DQGPQALSAEKELQIQVSDVNDNAPVFEKSRYEVSTWENNPPSLHLITLKAHDADLGSNG 492

  Fly  1083 RISYEIIEGNTERMFGVFPD-GYLFVRAPLDREERDYYALTVSCRDAGQPSRSSVVPVVIHVIDE 1146
            ::||.|.:.....:..:..: |.:..:..||.||...:...|...|.|||..||.:.|.:.::|.
  Rat   493 KVSYRIKDSPVSHLVIIDSETGEVTAQRSLDYEEMAGFEFQVIAEDRGQPQLSSSISVWVSLLDA 557

  Fly  1147 NDNAPQ-----FTNSTFTFSIPENA----------------PADT--------------FVGKLT 1176
            |||.|:     .:....|.|:..||                ||.|              .:..:.
  Rat   558 NDNTPEVIQPALSEGKATLSVLVNASTGHLLLPIESPSGMDPAGTGPTPPKATHSPWSFLLVTIV 622

  Fly  1177 AVDRDIGRNAELSFTLSSQTQDFTIDTRNGFIKTLRPFDREALVKVSRNAEASGEDGSLRGSMAG 1241
            |.|.|.|.|.||.:::.|        ..:..:..|.|...:..:.|: ||          .|:.|
  Rat   623 ARDADSGANGELLYSIQS--------GNDAHLFVLSPSLGQLFINVT-NA----------SSLIG 668

  Fly  1242 NYMLLEATVSDNGIPRLQDKVKVKVI-VTDVN---DNA--PEFLRAPYHVTISEGASEGTHITHV 1300
            :...|...|.|.|.|.||.:|.:||: ||.::   |:|  |..|..|....|....     :..|
  Rat   669 SQWDLGIVVEDQGSPSLQTQVSLKVVFVTSMDHLRDSAHEPGILSTPALAMICLAV-----LLAV 728

  Fly  1301 FTQDADEGLNGDVYYSLA----KGNEAGQFNLDSATGQLSLGRRLDRESQEIHHLIVVAKDAALK 1361
            |      ||...:..|:.    :.|.|  :|...|.   |:.|...:..|              |
  Rat   729 F------GLILALLVSICRIEKRDNRA--YNCREAE---SMYRHQPKRPQ--------------K 768

  Fly  1362 HPLSSNASITIVVLDENDNAPEFT---QSSSEVSVLET------------SPTGTELMRFRASDA 1411
            |...::..:..::..:.|.|.|..   :.:|:.:::|.            :||   |.|...:..
  Rat   769 HIQKADIHLVPMLRAQEDEAEEVRPPHKDTSKETLMEAGWDSCLQAPFHLTPT---LYRTLRNQG 830

  Fly  1412 DQG--VNSQVVFSISAGNRRDTFHIDSITGSLYLHKPLDYEDITSYTLNITASDCGTPSLSTTVL 1474
            :||  ..||.|.       :|||:.      |:.|.  ...:.:...||:..|   .|:|...:|
  Rat   831 NQGALAESQEVL-------QDTFNF------LFNHP--RQRNASRENLNLPES---PPTLRQPLL 877

  Fly  1475 YNVLVVDDNDNPPIFPSTAIVRQIKEGIPLK---TPIVTVTADD-----PDS------------G 1519
            .                           |||   :||..||.|.     |.|            .
  Rat   878 K---------------------------PLKVPGSPIARVTGDQGSKEAPQSPPASSATLRRQRN 915

  Fly  1520 LNGKVSYAISKQEPQLPQGRHFGINTETGVIHTLREIDRESIDTFRLTVVATDRAQPSERQLSTE 1584
            ||||||          |:|       |:.....||.:       .||:|.|.....|.|      
  Rat   916 LNGKVS----------PKG-------ESSPHQILRSL-------VRLSVAAFAERNPVE------ 950

  Fly  1585 KLVTVIVEDINDNAPV-FVSMNAAILPP------------KFSTSKGSSTAVMQVHAKDADS--- 1633
                   |...|:.|| .:|...::|..            |:|...|||.|.:    .|.|.   
  Rat   951 -------ELAGDSPPVQQISQLLSLLHQGQFQPKPNHRGNKYSAKPGSSRATI----PDTDGLGI 1004

  Fly  1634 SSNGLVTYEIVSGP--------------QELFK-LQRNTGII---TFTPGPQFKQEVRYQLT--- 1677
            ...||...::..||              :||.. |..|||:.   ...|.|.:...:...||   
  Rat  1005 RPGGLSEPDLEEGPPSPEEDLSVKRLLEEELSSLLDPNTGLALDKLSPPDPAWMARLSLPLTTNY 1069

  Fly  1678 ---LKSTDEAVQSERRSSEVYITIITPGSGGSESSVPQFEQRSKLSGSVYENEPIGTSIL----- 1734
               |.|.|.|...|.|:.:.:...:.||        |:.........|.:.:|.  :|:|     
  Rat  1070 RDNLSSPDAAASEEPRTFQTFGKTVGPG--------PELSATGTRLASTFVSEM--SSLLEMLLE 1124

  Fly  1735 --TVTAHLASAEIEYF----------VTNVTATGSRGQVDRLFDIDAKLG 1772
              ||....|||.:...          :....|:||..|:.|....::.||
  Rat  1125 QNTVPVEAASAALRRLSVCGRTLSLDLATSGASGSEAQLGRKKAAESSLG 1174

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ftNP_477497.1 Cadherin_repeat 71..152 CDD:206637
Cadherin_repeat 163..266 CDD:206637
Cadherin_repeat 275..378 CDD:206637
Cadherin_repeat 393..490 CDD:206637 26/109 (24%)
Cadherin_repeat 498..594 CDD:206637 32/102 (31%)
Cadherin_repeat 603..704 CDD:206637 40/100 (40%)
Cadherin_repeat 735..814 CDD:206637 7/78 (9%)
Cadherin 843..>907 CDD:394985 17/63 (27%)
Cadherin 950..1026 CDD:394985 1/75 (1%)
Cadherin_repeat 1053..1149 CDD:206637 30/96 (31%)
Cadherin_repeat 1157..1274 CDD:206637 34/150 (23%)
Cadherin_repeat 1282..1380 CDD:206637 16/101 (16%)
Cadherin_repeat 1390..1485 CDD:206637 21/108 (19%)
Cadherin_repeat 1497..1597 CDD:206637 28/119 (24%)
Cadherin_repeat 1621..1699 CDD:206637 23/104 (22%)
Cadherin_repeat 1720..1818 CDD:206637 16/70 (23%)
Cadherin_repeat 1827..1918 CDD:206637
Cadherin_repeat 1926..2023 CDD:206637
Cadherin_repeat 2031..2162 CDD:206637
Cadherin_repeat 2172..2274 CDD:206637
Cadherin_repeat 2282..2380 CDD:206637
Cadherin_repeat 2388..2487 CDD:206637
Cadherin_repeat 2495..2592 CDD:206637
Cadherin_repeat 2600..2694 CDD:206637
Cadherin_repeat 2710..2806 CDD:206637
Cadherin_repeat 2814..2909 CDD:206637
Cadherin_repeat 2917..3009 CDD:206637
Cadherin 3018..3114 CDD:394985
Cadherin 3129..3220 CDD:394985
Cadherin_repeat 3233..3330 CDD:206637
Cadherin_repeat 3338..3434 CDD:206637
Cadherin_repeat 3443..3541 CDD:206637
Cadherin_repeat 3550..3647 CDD:206637
Cadherin_repeat 3657..3753 CDD:206637
EGF 4017..4047 CDD:394967
EGF_CA 4056..4090 CDD:238011
EGF_CA 4094..4128 CDD:238011
Laminin_G_1 4156..4306 CDD:395008
LamG 4428..4543 CDD:238058
Pcdh12NP_446396.1 Cadherin_2 30..110 CDD:462413 17/85 (20%)
Cadherin_repeat 138..239 CDD:206637 33/103 (32%)
Cadherin_repeat 250..347 CDD:206637 40/97 (41%)
Cadherin_repeat 362..455 CDD:206637 34/326 (10%)
Cadherin_repeat 464..560 CDD:206637 30/95 (32%)
Cadherin_repeat 617..693 CDD:206637 23/94 (24%)
Blue background indicates that the domain is not in the aligned region.

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