Protein Alignment Naprt and NAPRT

DIOPT Version :9

• Sequence 1: NP_001097077.1
• Gene: Naprt / 33626
• FlyBaseID: FBgn0031589
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: XP_016869464.1
• Gene: NAPRT / 93100
• HGNCID: 30450
• Length: 690
• Species: Homo sapiens
• Alignment Length: 692
• Identity: 246/692 - (35%)
• Similarity: 349/692 - (50%)
• Gaps: 187/692 - (27%)

  Fly    26 QPLLTDLYQITMAYAYWKSDKTDDTAVFDLFFRNNPFHGEFTIFAGLEECLKFLDSFHYSQSDIE 90
            :||||||||.|||..||::.:..|.|.|:||||..||.|.|.:.|||.:|::||.:|....:|::
Human    14 RPLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQ 78

  Fly    91 YLKQTLPEGIEHEFFEYLGNLTARDVTLYAIDEGTVAFPRVPIIKIEGPLIIVQLLETTLLTLVN 155
            :|...||...:..|||:|..|...:||:.|:.||::|||.||::::.|||::||||||.||.||:
Human    79 FLASVLPPDTDPAFFEHLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVS 143

  Fly   156 YASLMATNAARYRMVAGKHVKLLEFGLRRAQGPDGGLSASKYSYTGGFDGTSNVLAGKLFNIPVK 220
            ||||:||||||.|::||...:|||.||||||||||||:||.|||.||||.:||||||:|..:||.
Human   144 YASLVATNAARLRLIAGPEKRLLEMGLRRAQGPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVA 208

  Fly   221 GTHAHAYITSFS-------------------SIG--------------ELKTRLIKHKQTG---- 248
            ||.||:::||||                   :.|              ::...|.:...||
Human   209 GTLAHSFVTSFSGSEVPPDPVSPSSKPCCLQATGPKPALALARGVPPRQVTPVLSQEAGTGCITF 273

  Fly   249 --------ILEDLLEH--------------------------AVRHRALLSHL---LDVSTEESS 276
                    :|..|:.|                          |.:.:..|..:   |.:..:|..
Human   274 ALKLGCPWLLPGLILHSWPPFFTDSVPQMLAPAAGEGPGVDLAAKAQVWLEQVCAHLGLGVQEPH 338

  Fly   277 EGELAAMVSYAIAFPDGFMALVDTYDVKSRETEQANTEPKHINDIKSENSPPKPKASPSTNGHQN 341
            .||.||.|:||:|||..|..|:|||.|
Human   339 PGERAAFVAYALAFPRAFQGLLDTYSV-------------------------------------- 365

  Fly   342 GQGVGHVNGHKTTNGHQNGSAQNNGSRTPKDTDIQDTSTSTTTTKTTATATGTLKTTTTVSNGTA 406
                                                                             
Human   366 ----------------------------------------------------------------- 365

  Fly   407 YLPKYVEKSFRSGLLNFSAVALALNDLGYHALGIRIDSGDLAYLSCLARETFEKVAERFKVPWFN 471
                     :||||.||.||||||.:|||.|:|:|:|||||...:...|:.|...|.:|:|||..
Human   366 ---------WRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKVFRAAAAQFQVPWLE 421

  Fly   472 KLTIVASNDINEDTILSLNEQGHKIDCFGIGTHLVTCQRQPALGCVYKLVEINGQPRIKLSQDVE 536
            .:.||.||:|:|:.:..|.::|.:::..||||.:|||.:||:||.|||||.:.||||:||::|.|
Human   422 SVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPE 486

  Fly   537 KVTMPGNKNAYRLYSADGHALIDLLQKVSEPPPAVGQKVLCRHPFQESKRAYVIPSHVESLYKVY 601
            |.|:||:|.|:||..:||..|:|:||...||.|..||::....|..: :...|.|:.||.|.::.
Human   487 KQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGAQ-EPCTVRPAQVEPLLRLC 550

  Fly   602 WKSGKICQQLPTLEQVREKVQISLKTLRNDHKRTLNPTPYKV 643
            .:.|::|:.||:|.:.|...|:||..|..:|:|..:|..|:|
Human   551 LQQGQLCEPLPSLAESRALAQLSLSRLSPEHRRLRSPAQYQV 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Naprt	NP_001097077.1	PLN02885	22..667	CDD:178473	246/692 (36%)
		NAPRTase_A	27..521	CDD:238804	196/567 (35%)
NAPRT	XP_016869464.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148258
Domainoid	1	1.000	162	1.000	Domainoid score	I4006
eggNOG	1	0.900	-	-		E1_COG1488
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H82285
Inparanoid	1	1.050	471	1.000	Inparanoid score	I1521
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62487
OrthoDB	1	1.010	-	-		D224002at33208
OrthoFinder	1	1.000	-	-		FOG0005048
OrthoInspector	1	1.000	-	-		oto89331
orthoMCL	1	0.900	-	-		OOG6_102036
Panther	1	1.100	-	-	LDO	PTHR11098
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2731
SonicParanoid	1	1.000	-	-		X3573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800