DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Naprt and NAPRT1

DIOPT Version :9

Sequence 1:	NP_001097077.1	Gene:	Naprt / 33626	FlyBaseID:	FBgn0031589	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_195412.3	Gene:	NAPRT1 / 829848	AraportID:	AT4G36940	Length:	559	Species:	Arabidopsis thaliana

Alignment Length:	684	Identity:	307/684 - (44%)
Similarity:	411/684 - (60%)	Gaps:	144/684 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNDRELGCAGGQFMDRGRM---NQNGVVQPLLTDLYQITMAYAYWKSDKTDDTAVFDLFFRNNPF 62
            |..:|.|..|.|   .||:   ..|.:|.|||.||||.||||||||:.|..:.:||||:||.|||
plant     1 MEKKENGLDGKQ---SGRVINGPTNPMVTPLLNDLYQFTMAYAYWKAGKQSERSVFDLYFRKNPF 62

  Fly    63 HGEFTIFAGLEECLKFLDSFHYSQSDIEYLKQTLPEGIEHEFFEYLGNLTARDVTLYAIDEGTVA 127
            .||:|||||||||:|||.:|:.:..:|::::.:|| |.|..|.:||..|...|:.:|||.||:|.
plant    63 GGEYTIFAGLEECIKFLANFNLTDEEIDFVRDSLP-GCEEAFCDYLRGLDCSDIEVYAISEGSVV 126

  Fly   128 FPRVPIIKIEGPLIIVQLLETTLLTLVNYASLMATNAARYRMVAGKHVKLLEFGLRRAQGPDGGL 192
            ||:||:::||||:.:||||||..|.|:|||||:||||||:|.||||...|||||.||||||||.:
plant   127 FPKVPLLRIEGPVAVVQLLETPFLNLINYASLVATNAARHRFVAGKSKLLLEFGARRAQGPDGAI 191

  Fly   193 SASKYSYTGGFDGTSNVLAGKLFNIPVKGTHAHAYITSFSSIGELKTRLIKHK------------ 245
            |||||.|.||||.||||.|||||.||::|||:||:::||.|:.|:..::::..
plant   192 SASKYCYLGGFDATSNVAAGKLFGIPLRGTHSHAFVSSFMSLDEIVDKVLRSSDGKSTCKDFICL 256

  Fly   246 -QTGILEDLLEHAVRHRALLSHLLDVSTEESSEGELAAMVSYAIAFPDGFMALVDTYDVKSRETE 309
             ||.:.:      :::.:.|..:.    .|:::.||||.:|||:|||:.|:||||||||
plant   257 VQTCLTK------IQNSSSLQGIF----SETNQSELAAFISYALAFPNSFLALVDTYDV------ 305

  Fly   310 QANTEPKHINDIKSENSPPKPKASPSTNGHQNGQGVGHVNGHKTTNGHQNGSAQNNGSRTPKDTD 374

plant   306 ----------------------------------------------------------------- 305

  Fly   375 IQDTSTSTTTTKTTATATGTLKTTTTVSNGTAYLPKYVEKSFRSGLLNFSAVALALNDLGYHALG 439
                                                     .:||:.||.|||||||:|||.|:|
plant   306 -----------------------------------------MKSGIPNFCAVALALNELGYKAVG 329

  Fly   440 IRIDSGDLAYLSCLARETFEKVAERFKVPWFNKLTIVASNDINEDTILSLNEQGHKIDCFGIGTH 504
            ||:|||||||||...|:.|..:....|||.|.|:.:.||||:||:|:.:||:|||::|.|||||:
plant   330 IRLDSGDLAYLSTEVRKFFCAIERDLKVPDFGKMIVTASNDLNEETVDALNKQGHEVDAFGIGTN 394

  Fly   505 LVTCQRQPALGCVYKLVEINGQPRIKLSQDVEKVTMPGNKNAYRLYSADGHALIDLLQKVSEPPP 569
            ||||..|.|||||:||||||.|||||||:||.||::|..|..|||:..:|:.|:|::...:||||
plant   395 LVTCYAQAALGCVFKLVEINNQPRIKLSEDVTKVSIPCKKRTYRLFGKEGYPLVDIMTGENEPPP 459

  Fly   570 AVGQKVLCRHPFQESKRAYVIPSHVESLYKVYWK--SGKICQQLPTLEQVREKVQISLKTLRNDH 632
            .||:::||||||.|||||||:|..||.|.|.||:  :.:..::|..|:::|.:....|:.:|.||
plant   460 KVGERLLCRHPFNESKRAYVVPQRVEELLKCYWRGNADEAREELEPLKELRNRCIKQLENMRPDH 524

  Fly   633 KRTLNPTPYKVAVSDNLYNFIHDLWLQNAPIGEL 666
            .|.||||||||:||..||:|||.|||..||:|||
plant   525 MRRLNPTPYKVSVSAKLYDFIHFLWLNEAPVGEL 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naprt	NP_001097077.1	PLN02885	22..667	CDD:178473	300/660 (45%)
Naprt	NP_001097077.1	NAPRTase_A	27..521	CDD:238804	217/506 (43%)
NAPRT1	NP_195412.3	PLN02885	16..559	CDD:178473	300/666 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	185	1.000	Domainoid score	I1005
eggNOG	1	0.900	-	-		E1_COG1488
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H82285
Inparanoid	1	1.050	620	1.000	Inparanoid score	I209
OMA	1	1.010	-	-		QHG62487
OrthoDB	1	1.010	-	-		D577034at2759
OrthoFinder	1	1.000	-	-		FOG0005048
OrthoInspector	1	1.000	-	-		otm3408
orthoMCL	1	0.900	-	-		OOG6_102036
Panther	1	1.100	-	-	O	PTHR11098
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840