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Protein Alignment Naprt and Nampt

DIOPT Version :9

Sequence 1:	NP_001097077.1	Gene:	Naprt / 33626	FlyBaseID:	FBgn0031589	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_067499.2	Gene:	Nampt / 59027	MGIID:	1929865	Length:	491	Species:	Mus musculus

Alignment Length:	671	Identity:	125/671 - (18%)
Similarity:	215/671 - (32%)	Gaps:	270/671 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LLTDLYQIT----------MAYAYW--KSDKTDDTAVFDLFFRNNPFHGEFTIFAGLEECL-KFL 79
            |.||.|::|          ..|:|:  :..||:::.|..:.:       |.|:|.||:..| |:|
Mouse    13 LATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKVRKVKY-------EETVFYGLQYILNKYL 70

  Fly    80 DSFHYSQSDIEYLKQTLPEGIEHEFF----------EYLGNLTARDVTLYAIDEGTVAFPRVPII 134
            .....::..|:..|:...|..:.:.|          :|.|:|   .:.:.|:.||:| .||..:
Mouse    71 KGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHL---PIEVKAVPEGSV-IPRGNV- 130

  Fly   135 KIEGPLIIVQLLETTLLTLVN----------YASLMATNAARYRMVAGKHV------------KL 177
                 |..|:..:.....|.|          |...:|||:...:.:..|::            ||
Mouse   131 -----LFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKL 190

  Fly   178 LEFGLRRAQGPD-GGLSASKYSYTGGFDGTSNV----LAGKLFNI--PVKG----THAHAYITSF 231
            .:||.|.....: .|:.||  ::...|.||..|    |..|.:..  ||.|    ...|:.||::
Mouse   191 HDFGYRGVSSQETAGIGAS--AHLVNFKGTDTVAGIALIKKYYGTKDPVPGYSVPAAEHSTITAW 253

  Fly   232 SSIGELKTRLIKHKQTGILEDLLEHAVRHRALLSHLLDVSTEESSEGELAAMVSYAIAFPDGFMA 296
            ....|              :|..||.|             |:.||..  .::||
Mouse   254 GKDHE--------------KDAFEHIV-------------TQFSSVP--VSVVS----------- 278

  Fly   297 LVDTYDVKSRETEQANTEPKHINDIKSENSP--PKPKASPSTNGHQNGQGVGHVNGHKTTNGHQN 359
              |:||:.:...:....:.:|:...:|..:|  .:|
Mouse   279 --DSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRP----------------------------- 312

  Fly   360 GSAQNNGSRTPKDTDIQDTSTSTTTTKTTATATGTLKTTTTVSNGTAYLPKYVEKSFRSGLLNFS 424
                  .|..|.||.::           .....|.....|..|.|...||.|
Mouse   313 ------DSGNPLDTVLK-----------VLDILGKKFPVTENSKGYKLLPPY------------- 347

  Fly   425 AVALALNDLGYHALGIRIDSGDLAYLSCLARETFEKVAERFKVPWFNKLTIVASNDIN--EDTIL 487
                           :|:..||                               ..|||  ::.:.
Mouse   348 ---------------LRVIQGD-------------------------------GVDINTLQEIVE 366

  Fly   488 SLNEQGHKID--CFGIGTHLVTCQRQPALGCVYK--LVEINGQPRIKLSQDVEK--VTMPGNKNA 546
            .:.::...|:  .||.|..|:....:..|.|.:|  .|..||     |..:|.|  |..| ||.:
Mouse   367 GMKQKKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNG-----LGVNVFKDPVADP-NKRS 425

  Fly   547 YRLYSADGHALIDLLQKVSEPPPAVGQKVLCRHP------FQESKRAYVIPSHVESLYKVYWKSG 605
            .:                       |:..|.|.|      .:|.|..  :..:...|....:|:|
Mouse   426 KK-----------------------GRLSLHRTPAGNFVTLEEGKGD--LEEYGHDLLHTVFKNG 465

  Fly   606 KICQQLPTLEQVREKVQISLK 626
            |:.:.. :.::||:..|::::
Mouse   466 KVTKSY-SFDEVRKNAQLNIE 485

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.