DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sr-CI and mep1bb

DIOPT Version :9

Sequence 1:	NP_001285599.1	Gene:	Sr-CI / 33621	FlyBaseID:	FBgn0014033	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_009294699.1	Gene:	mep1bb / 327586	ZFINID:	ZDB-GENE-030131-5797	Length:	774	Species:	Danio rerio

Alignment Length:	574	Identity:	116/574 - (20%)
Similarity:	187/574 - (32%)	Gaps:	196/574 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 LVGGRTAYCDGERWS-TQLGSCRRSNHTRDHSCDFESEDQCGW----EAETTFRRPWKRVSTVSD 164
            ::|.|..:.|.:... .:|.:|..|:...| |||||.|:.||.    ||::|  ..|:||...:.
Zfish   246 VIGQRMEFSDSDLLKLNRLYNCTSSSTFLD-SCDFELENICGMIQKGEADST--AEWRRVPEAAG 307

  Fly   165 IHSLRTGPRHDHT--FKNESGGHYMRMETQMGAYGSYHLLSP--IYPRSLTLKTACCFRFHYFMF 225
                  ||..|:|  .:.|..|::|...|..|..|:..||..  :||:    :...|.:|..|..
Zfish   308 ------GPDTDYTNMGRCEGKGYFMHFSTAGGPEGAKALLESRVLYPK----RGFQCLQFFVFNS 362

  Fly   226 GAGVDNLVVSVKPVSMPMATMWNRFRANCSKFEISGQQGT-------------QW-LEHTISIDE 276
            |...|.|            .:|.|      :|:.....||             :| |:| ||::
Zfish   363 GHTSDRL------------RIWTR------EFDTENPNGTLRLVQQIHAPPGERWQLQH-ISLN- 407

  Fly   277 MQEDFQVIFTATDARSQFGDIAIDDVKLMTGSECG-----TNGFSTTTEPTA------------- 323
            :...|:|:|..|......|.::|||:.| :.:.|.     ...|.:..|.|.
Zfish   408 VSRKFRVVFEGTKGTGSSGGLSIDDINL-SETRCPDHVWIVRDFKSILENTPMDTAIYSPRFTSR 471

  Fly   324 ----------PTG-------------------------------------------------SNE 329
                      |.|                                                 ||:
Zfish   472 LGYSFQMGLYPNGTAGNPGEMGAYAHLVSGDAAVDGGLVWPAQWKQMTMMMMDQNADIRRRMSNQ 536

  Fly   330 QPLVYD-MMSCSG----------RCGTSISASNITNNGIVMGCGCNDECLSDETCCLNYLEECTK 383
            :.:..| .|:..|          :.|..::..|.|......|.|.............::::....
Zfish   537 RSVTTDPNMTVEGSLNLFWDDPRKVGVKVTDDNGTEYFRGPGAGTPVYLTQARALSRDFIKGGDA 601

  Fly   384 ELLTTTED--DISSLPPTVTSTSTSTTRKSTTTTTTSTTTTSTTTTKRPTTTTTTTKATT-TKRT 445
            ..|.|.||  |:.:..|..::|.|..|...|..|....:||::..|.  |::.|.|.|.| |..:
Zfish   602 IFLLTMEDISDLVASQPLPSTTVTPATSAHTGPTNPDNSTTASPATH--TSSITHTSADTHTSSS 664

  Fly   446 TTTKKPTTTSTTPKPTTTTS-------------------------------TTPKSTTSTTSTTS 479
            ||:...:||...|.|..:..                               ...||:|..|..|:
Zfish   665 TTSSSSSTTVPPPDPCVSLQCENDGVCVQDDAGQPVCRCAVGSDWWYYGERCQHKSSTRHTVVTA 729

  Fly   480 TTPTTTTTINVFTTKKTTIMIPTSSTEKTTGINTTMKTRKRITWNVDPQDIEGH 533
            ......|.:         :|:      ..|.::.....::|.|..:|..||..|
Zfish   730 VLAAGLTLL---------LML------AITAVSVVCVKKRRKTVKLDTHDITMH 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sr-CI	NP_001285599.1	CCP	22..72	CDD:214478
		CCP	77..125	CDD:214478	4/20 (20%)
		MAM	131..308	CDD:214533	54/198 (27%)
		MAM	136..308	CDD:99706	52/193 (27%)
		Somatomedin_B	335..385	CDD:295334	8/60 (13%)
mep1bb	XP_009294699.1	ZnMc	39..267	CDD:294052	4/20 (20%)
		Astacin	81..269	CDD:279708	5/22 (23%)
		MAM	277..441	CDD:279023	52/196 (27%)
		MAM	277..440	CDD:99706	52/195 (27%)
		MATH	440..608	CDD:295307	18/167 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I5116
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960