DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HTR6 and htr6

DIOPT Version :9

Sequence 1:	NP_000862.1	Gene:	HTR6 / 3362	HGNCID:	5301	Length:	440	Species:	Homo sapiens
Sequence 2:	XP_002942005.2	Gene:	htr6 / 100493899	XenbaseID:	XB-GENE-962340	Length:	418	Species:	Xenopus tropicalis

Alignment Length:	440	Identity:	266/440 - (60%)
Similarity:	308/440 - (70%)	Gaps:	44/440 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    15 WGAG--------PPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTS 71
            |..|        ||:.     |:||.||::|.||...|||||.||.||.:||||||:||||||.|
Frog     5 WDGGKGATQRSSPPNV-----WMAAFLCLIILLTTVGNSLLILLIFTQRSLRNTSNYFLVSLFMS 64

Human    72 DLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKL 136
            |||||||||||||||.|||:|:|....|.:|.:||||||||||||||:|||||||||:|||:|||
Frog    65 DLMVGLVVMPPAMLNELYGKWILDVDFCCIWYSFDVMCCSASILNLCVISLDRYLLIISPLKYKL 129

Human   137 RMTPLRALALVLGAWSLAALASFLPLLLGWHE-------LGHARPPVPGQCRLLASLPFVLVASG 194
            |||..|||.|:|..|:|||||||||:.|||||       :.........||||:.|||:.||||.
Frog   130 RMTSCRALCLILATWTLAALASFLPIELGWHEQDFEIQHMNMTSGTEEKQCRLIVSLPYALVASC 194

Human   195 LTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKH 259
            |||||||.||.||||||||||||||||||||||.:.|.:.:..||...|     :.|||:..|||
Frog   195 LTFFLPSVAISFTYCRILLAARKQAVQVASLTTNVPSASEDHTQVLALP-----AVDSRKFVTKH 254

Human   260 SRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFM 324
            |:||||||||||||||||||.||||||||:|||||||:.|||||:||||||||||||||||||||
Frog   255 SKKALKASLTLGILLGMFFVAWLPFFVANVVQAVCDCVPPGLFDLLTWLGYCNSTMNPIIYPLFM 319

Human   325 RDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGS 389
            ||||||:|::|||  |.|.|..||   |:|.|:|.||.||||:.||.|....||...:..|:
Frog   320 RDFKRAMGKYLPC--CRRSRVISL---SIRNSNSAPRLGLSLRNVLTLRGETDSMYSATLGN--- 376

Human   390 SGLRLTAQLLLPGEATQD-PPLPTRAAAAVNFFNIDPAEPELRPHPLGIP 438
                   :.|||...... .|||..||.:||.|::   |.|::.|.|..|
Frog   377 -------EHLLPNSKDHSTDPLPVTAADSVNLFDL---EQEMQVHQLNTP 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HTR6	NP_000862.1	7tmA_5-HT6	27..331	CDD:320182	220/310 (71%)
		TM helix 1	28..54	CDD:320182	15/25 (60%)
		TM helix 2	61..87	CDD:320182	23/25 (92%)
		TM helix 3	99..129	CDD:320182	24/29 (83%)
		TM helix 4	141..164	CDD:320182	15/22 (68%)
		TM helix 5	185..214	CDD:320182	23/28 (82%)
		TM helix 6	261..291	CDD:320182	26/29 (90%)
		TM helix 7	299..324	CDD:320182	23/24 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..392		18/45 (40%)
htr6	XP_002942005.2	7tmA_5-HT6	20..326	CDD:320182	220/315 (70%)
		TM helix 1	21..47	CDD:320182	15/25 (60%)
		TM helix 2	54..80	CDD:320182	23/25 (92%)
		TM helix 3	92..122	CDD:320182	24/29 (83%)
		TM helix 4	134..157	CDD:320182	15/22 (68%)
		TM helix 5	185..214	CDD:320182	23/28 (82%)
		TM helix 6	216..286	CDD:320182	49/74 (66%)
		TM helix 7	294..319	CDD:320182	23/24 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H673
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1173208at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010