DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and KIRREL2

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_954649.3	Gene:	KIRREL2 / 84063	HGNCID:	18816	Length:	708	Species:	Homo sapiens

Alignment Length:	768	Identity:	159/768 - (20%)
Similarity:	244/768 - (31%)	Gaps:	264/768 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 FW--TRWTANPAQFDNVAIG---EVQLSSGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKAK 131
            :|  .:||.:     .:|:|   ::...|.|.:......|.:||.|:.|.. .|...:||    :
Human    50 YWGLVQWTKS-----GLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVEL-EDEASYEC----Q 104

  Fly   132 GTGADVHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTCSSIGGS-PDPTITWYREG---SN 192
            .|.|.:......|.||.||..|.:..|.........|..|||.|.|.: |.|.:.|:|:|   ..
Human   105 ATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDG 169

  Fly   193 TPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEV 257
            .....|:||.||... ..:||::.|...||||.:.|..|::|:..|:  :...||::.|.|.|.:
Human   170 ATFHQTLLKEGTPGS-VESTLTLTPFSHDDGATFVCRARSQALPTGR--DTAITLSLQYPPEVTL 231

  Fly   258 GPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYT----CIA 318
            . .:|..|:........|...|:|.|...||.:.|..:..:....:..|:  ||...|    |..
Human   232 S-ASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVA--DASFLTEPVSCEV 293

  Fly   319 DNGLGKTGEQELILDILYPPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYN 383
            .|.:| :..:...||:|:.|::..:.:....:.|:..:..|....||.| .:.|.:........:
Human   294 SNAVG-SANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLP-RVTWTRRGGAQVLGS 356

  Fly   384 GDVLTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPVVHVGN 448
            |..|.|.||..:.||:|:|||             ..|.|.    :|....:|.:|.|.|
Human   357 GATLRLPSVGPEDAGDYVCRA-------------EAGLSG----LRGGAAEARLTVNAP------ 398

  Fly   449 GVTLTCSANPPGWPVPQYRWFRDMDGEFSSTQKILAQGPQYSIPKAHLGNEGKYHCHAVNELGIG 513

Human   399 ----------------------------------------------------------------- 398

  Fly   514 MMATIVLEIHQPPQFL---AKLQQHMTRRVADTDYTVTCSAKGKPAP-SVKWLKDAVEILPEENL 574
               .:|..:|..|.||   |:||               |.....||| :|.|..|
Human   399 ---PVVTALHSAPAFLRGPARLQ---------------CLVFASPAPDAVVWSWD---------- 435

  Fly   575 YEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRG----------------------LYT 617
                       .|.:...||.:|..:..|     .|..||                      .:.
Human   436 -----------EGFLEAGSQGRFLVETFP-----APESRGGLGPGLISVLHISGTQESDFSRSFN 484

  Fly   618 CLYQNEV--NSANSSMQLRIEHEPIVLHQYNKVAFDIRETAEVVCKVQA---------------- 664
            |..:|.:  ..|.:|:..|                |:..|..:|..|.|
Human   485 CSARNRLGEGGAQASLGRR----------------DLLPTVRIVAGVAAATTTLLMVITGVALCC 533

  Fly   665 --YPKPEFQWQFGNNPSPLTMSSDG-------HYEISTTTDNNDIYTSVLKINSLTHSDYGEYTC 720
              :.|....:....|...:..||||       ..|..:..|...|          .|:|:.:...
Human   534 WRHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPI----------VHTDHSDLVL 588

  Fly   721 RVANTLDTIRAPIRLQQKGPPEKPTN----LRATEVGHNYVSLSWDPGFDGGL 769
            ....||:|             :.|||    :|...|.   :||...||  |||
Human   589 EEEGTLET-------------KDPTNGYYKVRGVSVS---LSLGEAPG--GGL 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	18/79 (23%)
		I-set	146..249	CDD:254352	35/106 (33%)
		Ig	168..249	CDD:299845	29/84 (35%)
		IGc2	268..323	CDD:197706	13/58 (22%)
		Ig_3	341..406	CDD:290638	17/64 (27%)
		Ig_2	437..514	CDD:290606	3/76 (4%)
		I-set	526..633	CDD:254352	25/134 (19%)
		Ig	546..632	CDD:143165	19/110 (17%)
		IG_like	654..736	CDD:214653	18/106 (17%)
		Ig	656..734	CDD:143165	17/102 (17%)
		FN3	741..848	CDD:238020	12/33 (36%)
KIRREL2	NP_954649.3	IG_like	30..119	CDD:214653	18/78 (23%)
		IGc2	38..106	CDD:197706	15/65 (23%)
		I-set	126..224	CDD:254352	31/100 (31%)
		Ig2_KIRREL3-like	141..223	CDD:143236	29/84 (35%)
		Cell attachment site. /evidence=ECO:0000255	149..151		0/1 (0%)
		Ig	231..306	CDD:299845	16/78 (21%)
		IG_like	234..308	CDD:214653	17/76 (22%)
		Ig	312..395	CDD:299845	22/100 (22%)
		I-set	317..395	CDD:254352	21/95 (22%)
		Ig	397..501	CDD:299845	28/218 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..601		14/78 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148517
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840