DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ed and SIGLEC1

DIOPT Version :9

Sequence 1:NP_001260013.1 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster
Sequence 2:NP_075556.1 Gene:SIGLEC1 / 6614 HGNCID:11127 Length:1709 Species:Homo sapiens


Alignment Length:1482 Identity:315/1482 - (21%)
Similarity:489/1482 - (32%) Gaps:424/1482 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 ENADLTLKCRFNDKYEA-NDFSFFWTRWTANPAQFDNVAIGEVQLSSGYRLDF--QPERGIYDLQ 111
            ||..:||.|  |...|| :|..:.|         :.|..:.|...|...||..  :.:.|.|..:
Human   338 ENQTVTLVC--NTPNEAPSDLRYSW---------YKNHVLLEDAHSHTLRLHLATRADTGFYFCE 391

  Fly   112 IKNVSYNRDNGRFECRIKAKGTGADVHQEFHNLTVLTPPHPPVISP---------GNIAVATEDK 167
            ::||..:..:|..                  ::.|..||..||::.         |.:..:...:
Human   392 VQNVHGSERSGPV------------------SVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSE 438

  Fly   168 PMELTCSSIGGSPDPTITWYREGSNTPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRN 232
            |:.....|.||.    |.....|.:...|..   .||.. |.:..|.|....|.|..:|||...|
Human   439 PLATLVLSHGGH----ILASTSGDSDHSPRF---SGTSG-PNSLRLEIRDLEETDSGEYKCSATN 495

  Fly   233 RAMNEGKRLEATATLNVN-YYPRVEVGPENPLRVERDRTAKLECNVDAKPKVPNVR--WNRNGRF 294
            ...|      ||:||:.: ...|:.:.|  ...|...:...|.|.....| .|:.|  |..||..
Human   496 SLGN------ATSTLDFHANAARLLISP--AAEVVEGQAVTLSCRSGLSP-TPDARFSWYLNGAL 551

  Fly   295 I----SSSLVHTIHRVSVQDAGKYTCIADNGLGKTG-EQELILDILYPP-----MVVIESKTREA 349
            :    .|||:  :...|..|||.|.|.|.:|...:| ....:|.:||||     ...::.....|
Human   552 LHEGPGSSLL--LPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGA 614

  Fly   350 EEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYNGDVLTLTSVRADHAGNYIC----------RA 404
            ..|....:.|.|.::| |..::.|.:         |.:..||:.:. .|...|          :|
Human   615 GAGRRGLLLCRVDSDP-PARLQLLHK---------DRVVATSLPSG-GGCSTCGGCSPRMKVTKA 668

  Fly   405 VN---------IMQSQGM---ERSERVGNSTVALLVRHRPGQAYITPNKP--VVHVGNGVTLTC- 454
            .|         :::.:|:   |.|..:||::.:....   |||.:....|  .:..|....||| 
Human   669 PNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFN---GQATVLAIAPSHTLQEGTEANLTCN 730

  Fly   455 -SANPPGWPVPQYRWFRDMDGEFSSTQKILAQGPQYSI---PKAHLGNEGKYHCHAVNELGIGMM 515
             |....|.|. .:.|||:        ..:.||||..::   |.|.. :...|.|..:.|.|..:.
Human   731 VSREAAGSPA-NFSWFRN--------GVLWAQGPLETVTLLPVART-DAALYACRILTEAGAQLS 785

  Fly   516 ATIVLEIHQPPQ------FLAKLQQHMTRRVADTDYTVTCSAKGKPAPSVKWLKDAVEILPEENL 574
            ..::|.:..||.      .|...|.||...:        |:...:|..       .:.:...|:|
Human   786 TPVLLSVLYPPDRPKLSALLDMGQGHMALFI--------CTVDSRPLA-------LLALFHGEHL 835

  Fly   575 YEVQTNPDQGLNGMVTVQSQLKFRGKARPNG-----NALVPGDRGLYTCLYQNEVNSANSSM--Q 632
            ......|.        |.|..:|:.||..|.     ..|..||.|.|.|...|.:.|:|:|:  |
Human   836 LATSLGPQ--------VPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQ 892

  Fly   633 LR---IEHEPIVLHQYNKVAFDIRETAEVVCKVQAYP-KPE---FQWQFGNNP-----------S 679
            :|   ::..|         :.:::|...||...|.:. .||   ::|.....|           :
Human   893 VRGAWVQVSP---------SPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFA 948

  Fly   680 PLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDY------------------GEYTCR----- 721
            .:|::..|.|........: ..||:....|| |..|                  |...||     
Human   949 AITLTQAGAYHCQAQAPGS-ATTSLAAPISL-HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP 1011

  Fly   722 ------------VANTLDTIRAP---------------IRLQQKGPPEKPTNLRATEVGHNYVSL 759
                        ||:||..:..|               :||:..|...:...:...|..:.....
Human  1012 PAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA 1076

  Fly   760 SWDPGFDGGLSKTKFFVSYRRVAMPREEQLIPDCATLANSNSA-----WVEVDCQR----DIPCK 815
            |....||......:.:..    |..||.||:.....:..::.|     |.:...||    .||..
Human  1077 SASADFDAQAVNVQVWPG----ATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLP 1137

  Fly   816 VTALEQHQSYAFKVKALNPKSDSPYSSEIMVTTKVSRIPPPLQVTYEPNTRTLGIDVGATCLNLV 880
            ...:....||...|   .|...:|..|. .:|..|...|..|::||...:.      |.....::
Human  1138 NVTVRDATSYRCGV---GPPGRAPRLSR-PITLDVLYAPRNLRLTYLLESH------GGQLALVL 1192

  Fly   881 AVVES-------MVNADSPMAAWEVVTTMDNLQLSGNGPTHKEKIIDRIIGARRVGGGRALGHTI 938
            ..|:|       :.:|...:|:....:..:.|:|...||..:::      |.........||...
Human  1193 CTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDE------GFYSCSARSPLGQAN 1251

  Fly   939 SEDEDDNGLNSLALEDENSPTVRVKLCLRTNPE-----------HCGD--------YTDAEIGRP 984
            :         ||.|..|.   |||.|.    ||           .|.|        ||....|| 
Human  1252 T---------SLELRLEG---VRVILA----PEAAVPEGAPITVTCADPAAHAPTLYTWYHNGR- 1299

  Fly   985 YIAEANALATPTLIAIIVSCVVFALFAGLILMFCRCKRNQSKKSAAAKDYEMDSVRPSIVAAQQN 1049
            ::.|..|.:...|:|.......::         |:.:..|..:|:          ||:  |.|..
Human  1300 WLQEGPAASLSFLVATRAHAGAYS---------CQAQDAQGTRSS----------RPA--ALQVL 1343

  Fly  1050 QAPPPYYPASGLDNKA-----------LEHSMDLALSMEDQKTALYATQNG-YSYHPGSGVVGVG 1102
            .||.....:|..|::|           .|...:||||.:.:   :.||.:| :|...|:|.|.|.
Human  1344 YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGK---VLATSSGVHSLASGTGHVQVA 1405

  Fly  1103 MGG---GVVGVGVGGS----VVSGMGGGVGGIGG---SGVGVNGIPGLSAHTMPGNEWVNMGYME 1157
            ...   .|..|..|..    ....:.|.:..||.   .|..|...|||.   :|....:|:    
Human  1406 RNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLD---VPEGAALNL---- 1463

  Fly  1158 NNYSNSNNGGSVNSQDSLWQVKMSAAAVGNQQGMVQAPMN----QYVEQQPAYGYDPLTHGGYGA 1218
             :.......|.|.:....|        ..|.:.:...|:.    .:|.:..|..|..|.....||
Human  1464 -SCRLLGGPGPVGNSTFAW--------FWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGA 1519

  Fly  1219 VDDYAP------YPHLTATPSQVGDEYHNLRNSQNPSRQDYCSDPYASVQKPKKRVDQHLDS--- 1274
            ... ||      ||..|.|.....:....||...: .|.|  |:|.||       :..||.|   
Human  1520 AAS-APVMLRVLYPPKTPTMMVFVEPEGGLRGILD-CRVD--SEPLAS-------LTLHLGSRLV 1573

  Fly  1275 -----------PYHDVSGLPNPYNMEHLEQDEVLPPQQHMSLSYDDSFEGEY 1315
                       |:..|...||...::    .|.|.|          |.:|||
Human  1574 ASSQPQGAPAEPHIHVLASPNALRVD----IEALRP----------SDQGEY 1611

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
edNP_001260013.1 Ig 50..147 CDD:299845 20/99 (20%)
I-set 146..249 CDD:254352 29/111 (26%)
Ig 168..249 CDD:299845 23/80 (29%)
IGc2 268..323 CDD:197706 19/60 (32%)
Ig_3 341..406 CDD:290638 13/74 (18%)
Ig_2 437..514 CDD:290606 21/83 (25%)
I-set 526..633 CDD:254352 26/119 (22%)
Ig 546..632 CDD:143165 21/92 (23%)
IG_like 654..736 CDD:214653 26/146 (18%)
Ig 656..734 CDD:143165 24/142 (17%)
FN3 741..848 CDD:238020 21/115 (18%)
SIGLEC1NP_075556.1 Ig 21..136 CDD:299845
IG_like 26..135 CDD:214653
Sialic acid binding. /evidence=ECO:0000250 122..126
C2-set_2 142..228 CDD:285423
Ig_2 245..323 CDD:290606
IG_like 247..323 CDD:214653
Ig 336..408 CDD:299845 20/98 (20%)
IG_like 338..408 CDD:214653 20/98 (20%)
Ig 430..503 CDD:143165 21/86 (24%)
IG_like 431..503 CDD:214653 21/85 (25%)
Ig_2 514..594 CDD:290606 23/84 (27%)
IG 516..594 CDD:214652 23/82 (28%)
IG_like 624..703 CDD:214653 17/89 (19%)
IG_like 715..792 CDD:214653 22/86 (26%)
ig 715..788 CDD:278476 21/82 (26%)
Ig 809..893 CDD:299845 24/106 (23%)
I-set 898..980 CDD:254352 16/92 (17%)
Ig_2 900..980 CDD:290606 16/90 (18%)
Ig 1003..1080 CDD:143165 12/76 (16%)
Ig_2 1093..1168 CDD:290606 18/82 (22%)
IG_like 1093..1168 CDD:214653 18/82 (22%)
I-set 1186..1256 CDD:254352 13/84 (15%)
Ig_2 1263..1342 CDD:290606 20/104 (19%)
IG_like 1271..1342 CDD:214653 16/92 (17%)
Ig 1363..1442 CDD:299845 19/81 (23%)
IG_like 1455..1529 CDD:214653 15/87 (17%)
Ig 1457..1518 CDD:299845 10/73 (14%)
Ig <1552..1630 CDD:299845 20/84 (24%)
IG 1552..1627 CDD:214652 20/84 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D35531at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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