DRSC/TRiP Functional Genomics Resources

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Protein Alignment ed and kirrel3a

DIOPT Version :10

Sequence 1:NP_523469.2 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster
Sequence 2:XP_068080114.1 Gene:kirrel3a / 571887 ZFINID:ZDB-GENE-091117-44 Length:788 Species:Danio rerio


Alignment Length:768 Identity:188/768 - (24%)
Similarity:286/768 - (37%) Gaps:189/768 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 DNVAIGEVQLSSGY-RLDF--QPERGIYDLQIKNVSYNRDNGRFECR-IKAKGTGADVHQEFHNL 144
            |.:|:|..:..||| |.|.  ...:|.|.|.|:.... .|:|.|||: |:..|.....     .|
Zfish    70 DGLALGVNRDLSGYPRYDVIGDHSKGEYHLLIERTEL-VDDGSFECQAIQVAGRSRPA-----QL 128

  Fly   145 TVLTPPHPPVISPGNIAVATEDKPMELTCSSIGGSPDPTITWYREG---SNTPLPATVLKGGTKD 206
            |||.||..|||....:........:.|||.:....|..:|.|.|.|   :......|:|:.| |.
Zfish   129 TVLVPPDDPVIIGAPVVSLRAGDSLNLTCHANNAKPAASIIWIRNGEVINGAAYTKTLLRDG-KR 192

  Fly   207 QPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEVGPENPLRVERDRTA 271
            :.|.:||.|.....:.|.:..|...|:|...||  |||.|:::.::|.|.:..| |..|......
Zfish   193 ESTVSTLHISASNIESGQQITCRASNKAAPNGK--EATVTIDIQHFPLVNLSVE-PQPVLEGNLV 254

  Fly   272 KLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYT----CIADNGLGKTGEQELIL 332
            |..|...|.|.|.:.||.:.|..|:.:...| :.|.| |...:|    |...|.||.|.....: 
Zfish   255 KFHCAAKANPPVTHYRWAKGGSMITDATGDT-YEVLV-DHSFFTEPVSCEVTNALGSTNISRNV- 316

  Fly   333 DILYPPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYNGDVLTLTSVRADHA 397
            |:.:.|.:..|.::.:.:.|......|....||: :||.|:|........|.:.|||.:||.:.|
Zfish   317 DVYFGPRLAAEPQSLQVDRGSDAVFSCAWIGNPS-LTIVWMKRGHGVVLSNENTLTLKAVRQEDA 380

  Fly   398 GNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTC---SANPP 459
            |.|:||||  :...|      ||...|.|.| :.|.....|..:..:: |....:.|   |..||
Zfish   381 GKYVCRAV--VPRVG------VGEKEVMLTV-NGPPSISSTQTQQALY-GEKGQIKCFIRSTPPP 435

  Fly   460 GWPVPQYRWFRDMDGEFSSTQKILAQGP--QYSIPKAHLGNEGK-----------------YHCH 505
                .:..|        |..:.:|..|.  :|::..... .||.                 |:|.
Zfish   436 ----DRIAW--------SWKETVLESGTSGRYTVETVST-EEGVISTLTMRNIVPTDFQTIYNCT 487

  Fly   506 AVNELG-------------------IGM-----MATIVL---------------EIH----QPPQ 527
            |.|..|                   ||:     :|.|||               ::|    ..|.
Zfish   488 AWNSFGSDTEIIRLKEQGSLRLAVIIGVAVGAFLALIVLIGTLGAFCCARLQRKDMHLVMSSLPV 552

  Fly   528 FLAKLQQHMTRRVADTDYTVTCSAKG-----------------KPAPSVKWL--------KDAV- 566
            .|:..|:.::..|...:.....|||.                 :...:||.:        :::| 
Zfish   553 SLSSRQREISGTVKSENLKGVVSAKNDIRVEIVHKDHNAAREPEEHSNVKQMMMERADFQQESVL 617

  Fly   567 ---EILPEE-----------------NLYEVQTNPDQGLNGMVTVQSQLKFR-------GKAR-P 603
               |:|.||                 |.::.|..|...|    |.....:.|       ||.| |
Zfish   618 KQLEVLQEEERELQHIKDPTNGYYSVNTFKEQPTPTISL----TANQNAEVRNPATATLGKHRVP 678

  Fly   604 NG-------NALVPGDRGLYTCLYQNEVNSANSSMQLRIEHEPIVLHQYNKVAFDIRETAEVVC- 660
            .|       |.|..|...||....:..:...:||::| .|.|    .|...:: |.....:..| 
Zfish   679 TGMSYTNIYNTLGAGPNRLYDYSQRFVLGMGSSSIEL-CERE----FQRGSLS-DSSSFQDTQCD 737

  Fly   661 -KVQAYPKPEFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTH 712
             .|.:|.|.:...|| :..|..::||..||. .:::.|:|: |..|:....||
Zfish   738 SSVSSYSKQDGYVQF-DKASKASVSSSSHYS-QSSSQNSDL-TRPLQKRMQTH 787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
edNP_523469.2 V-set 50..147 CDD:462230 21/66 (32%)
Ig 153..249 CDD:472250 29/98 (30%)
Ig strand B 169..173 CDD:409353 1/3 (33%)
Ig strand C 183..187 CDD:409353 1/3 (33%)
Ig strand E 211..215 CDD:409353 2/3 (67%)
Ig strand F 225..230 CDD:409353 1/4 (25%)
Ig strand G 242..245 CDD:409353 2/2 (100%)
Ig_3 253..320 CDD:464046 20/70 (29%)
Ig_3 337..406 CDD:464046 22/68 (32%)
Ig_2 437..>504 CDD:464026 14/88 (16%)
Ig 525..635 CDD:472250 33/170 (19%)
Ig strand B 545..549 CDD:409568 0/3 (0%)
Ig strand C 558..562 CDD:409568 2/3 (67%)
Ig strand E 587..591 CDD:409568 0/3 (0%)
Ig strand F 615..620 CDD:409568 2/4 (50%)
Ig strand G 628..631 CDD:409568 1/2 (50%)
Ig_3 639..724 CDD:464046 19/76 (25%)
FN3 741..848 CDD:238020
kirrel3aXP_068080114.1 Ig 39..130 CDD:472250 20/65 (31%)
Ig strand B 52..56 CDD:409353
Ig strand C 64..68 CDD:409353
Ig strand E 92..101 CDD:409353 3/8 (38%)
Ig strand F 111..116 CDD:409353 3/4 (75%)
Ig strand G 123..126 CDD:409353 0/2 (0%)
IgI_2_KIRREL3-like 136..233 CDD:409416 29/99 (29%)
Ig strand A 137..140 CDD:409416 2/2 (100%)
Ig strand A' 143..147 CDD:409416 0/3 (0%)
Ig strand B 154..161 CDD:409416 3/6 (50%)
Ig strand C 166..171 CDD:409416 1/4 (25%)
Ig strand C' 174..176 CDD:409416 1/1 (100%)
Ig strand D 179..186 CDD:409416 0/6 (0%)
Ig strand E 193..201 CDD:409416 3/7 (43%)
Ig strand F 210..218 CDD:409416 1/7 (14%)
Ig strand G 224..230 CDD:409416 5/7 (71%)
Ig_2 241..318 CDD:464026 22/80 (28%)
Ig 322..403 CDD:472250 28/89 (31%)
Ig strand B 339..343 CDD:409353 0/3 (0%)
Ig strand C 352..356 CDD:409353 2/3 (67%)
Ig strand E 368..372 CDD:409353 1/3 (33%)
IgI_5_KIRREL3 405..502 CDD:409479 19/110 (17%)
Ig strand A 406..410 CDD:409479 1/3 (33%)
Ig strand A' 412..415 CDD:409479 1/2 (50%)
Ig strand B 423..430 CDD:409479 1/6 (17%)
Ig strand C 437..442 CDD:409479 1/12 (8%)
Ig strand C' 444..447 CDD:409479 0/2 (0%)
Ig strand D 455..462 CDD:409479 1/6 (17%)
Ig strand E 465..472 CDD:409479 1/6 (17%)
Ig strand F 483..490 CDD:409479 3/6 (50%)
Ig strand G 493..500 CDD:409479 1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

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