DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ed and zgc:171470

DIOPT Version :9

Sequence 1:NP_001260013.1 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster
Sequence 2:NP_001104655.1 Gene:zgc:171470 / 565848 ZFINID:ZDB-GENE-080204-4 Length:374 Species:Danio rerio


Alignment Length:415 Identity:104/415 - (25%)
Similarity:160/415 - (38%) Gaps:101/415 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 FLIALVALSS----TTLADESIDTRENADLTLKCRFNDKYEAND--FSFFWTRWTANPAQF---- 83
            ||:.:..:||    .|.:...|...:::.:.:.|.|  ||....  ...||.:      .|    
Zfish    13 FLLMIHMVSSADWAVTYSSSHICALKDSSVIMSCTF--KYPTGHQIMKVFWNK------DFVEHR 69

  Fly    84 DNVAIGEVQLSSGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIK-AKGTGADVHQEFHNLTVL 147
            |.:|          .|...||   |..:::.:...:.|    |.:| :..|..|.|..:......
Zfish    70 DELA----------DLSEHPE---YSQRLQYLGDKQQN----CTVKLSLVTKKDEHMYYFRFITD 117

  Fly   148 TP-----PHPPV---------ISPGNIAVATEDKPMELTC-SSIGGSPDPTITWYR------EGS 191
            .|     .:|.|         .||..:   ||...:.||| ||...:..||..|||      |.|
Zfish   118 QPGGKWAGYPGVRLSVTDLQLESPERV---TEGDSVRLTCRSSCNLTDTPTFIWYRNSERMIERS 179

  Fly   192 NTPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPR-V 255
            :..|..:|                  ||||.| :|:|.|....:...:     ..|||.|.|: |
Zfish   180 SELLLHSV------------------RREDAG-RYRCAVHGHTLTSPE-----IYLNVMYPPKSV 220

  Fly   256 EVGPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYTCIADN 320
            .|.......:....:..|.|:.|:.|.. .:.|.:....:.|..:..|.::|..|:|:|.|.|.|
Zfish   221 SVSISGSAVIVSGDSVTLNCSSDSNPPA-EISWFKGETSVGSGRIFNISKISSGDSGEYKCRARN 284

  Fly   321 GLGKTGEQELILDILYPPMVVIESKTREA--EEGDTVTIRCNVTANPAPVTIEWLK-ENSPDFRY 382
            .||:.....:.||:.||||.|..|.:..|  ..|.:||:.|:..:|| |..|.|.| |....|  
Zfish   285 ALGEKYSDPVTLDVQYPPMNVSVSISGSAVIMSGHSVTLSCSSDSNP-PAQISWFKGETLVGF-- 346

  Fly   383 NGDVLTLTSVRADHAGNYICRAVNI 407
             |.:.:::.:|        |||.|:
Zfish   347 -GRIFSISKIR--------CRARNV 362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
edNP_001260013.1 Ig 50..147 CDD:299845 19/103 (18%)
I-set 146..249 CDD:254352 30/123 (24%)
Ig 168..249 CDD:299845 23/87 (26%)
IGc2 268..323 CDD:197706 14/54 (26%)
Ig_3 341..406 CDD:290638 20/67 (30%)
Ig_2 437..514 CDD:290606
I-set 526..633 CDD:254352
Ig 546..632 CDD:143165
IG_like 654..736 CDD:214653
Ig 656..734 CDD:143165
FN3 741..848 CDD:238020
zgc:171470NP_001104655.1 Ig 25..114 CDD:299845 21/113 (19%)
IG_like 140..213 CDD:214653 27/99 (27%)
Ig_2 140..>197 CDD:290606 24/78 (31%)
Ig_2 224..298 CDD:290606 17/74 (23%)
IG_like 225..298 CDD:214653 17/73 (23%)
IG_like 310..373 CDD:214653 19/65 (29%)
Ig_2 314..373 CDD:290606 18/61 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D35531at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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