DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ed and hspg2

DIOPT Version :9

Sequence 1:NP_001260013.1 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster
Sequence 2:XP_021325650.1 Gene:hspg2 / 565429 ZFINID:ZDB-GENE-080807-4 Length:3701 Species:Danio rerio


Alignment Length:1427 Identity:299/1427 - (20%)
Similarity:470/1427 - (32%) Gaps:430/1427 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 LQIKNVSYNRDNGRFECRIKAKGTGADVHQE------FHNLTVLTP---PHPPVISPGNIAVATE 165
            |.|.:|. ..|.|.:.|  ||..|    |.|      .|..:...|   ||..| ||..:.: .|
Zfish  2077 LTISSVD-RSDEGEYIC--KALNT----HGEHTARGVLHVQSTGQPNGLPHVQV-SPQRVEI-YE 2132

  Fly   166 DKPMELTCSSIGGSPDPTITWYREGSNTPLPATVLKGGTKDQPTNATLSIIPRRED--------- 221
            .:.:.|.|.:| |||.|::.|.:.|.:.| |..:...|.....:| :|.::.||.:         
Zfish  2133 GETLRLYCRAI-GSPTPSLKWNKRGGSLP-PQAIPSHGFHQFKSN-SLDVLQRRIEELQARMDRT 2194

  Fly   222 -------------DGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEVGPENPLRVERDRTAKL 273
                         |...|.||..|.|.:....::.:.|...|....|.:.|.:...:|.: ...|
Zfish  2195 DIGTLVVPNIRLSDAGTYLCVGTNAAGSSEAHIDVSV
TKGENILSGVIIQPPSASVIEGE-ALDL 2258

  Fly   274 ECNVDAKPKVPNVRWNRNGRFISSS--LVHT---IHRVSVQDAGKYTCIADNGLGKTGEQELILD 333
            .|.|.. ....:|:|:|.|..:||:  ::.|   |.|.|..|.|.|.|..:||   ...|:..:.
Zfish  2259 NCLVPG-TSTGSVKWSRAGGLLSSNHQVLETRLRILRASADDTGDYICTVENG---PSPQKATVS 2319

  Fly   334 I---------LYPPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENS----------PD 379
            :         |..|::.||..:...::|::.:.||.|.....||.:||...|:          ||
Zfish  2320 VSVTSSASLGLQTPIISIEPHSAVVKQGESASFRCKVHNGAQPVRLEWKLTNNLPLPDNVKVGPD 2384

  Fly   380 FRYNGDVLTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPV- 443
                ..::|:|:.:|.:.|.|.|.|.|:   .||.      :|.|:|:||..| :|.:||..|| 
Zfish  2385 ----SSIMTVTNAQAKNQGTYRCVASNL---YGMT------HSIVSLIVRESP-KAVVTPAGPVR 2435

  Fly   444 VHVGNGVTLTCSANPPGWPVPQYRWFRDMDGE----FSSTQ--------KILAQGPQYSIPKAHL 496
            |.||:.:.|.|.|  .|.|.|..||.| :|..    .|||.        ::|...|:        
Zfish  2436 VRVGDPINLECQA--AGEPRPSVRWHR-LDNNRKTMLSSTVPVDSSAIIQVLVARPE-------- 2489

  Fly   497 GNEGKYHCHAVNELGIGMMATIVLEIHQPPQF----LAKLQQHMTRRVADTDYTVTCSAKGKPAP 557
             :.|.|.|.|.|..|. ....:.:.:...||.    .|.:::.|...|..:..|:.|.|.|.|.|
Zfish  2490 -DSGTYVCSAQNNQGT-TETRVEVFVEGGPQVPTVPRASVREPMIIVVEGSTATLHCDAHGFPKP 2552

  Fly   558 SVKWLKDAVEILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPG----DRGLYTC 618
            ::.|.|:                           :|.|.:|.|...| :.::|.    |.|.|.|
Zfish  2553 TITWFKE---------------------------RSSLPWRHKIVDN-SLILPNVGRQDSGQYVC 2589

  Fly   619 LYQNEVNSANSSMQLRIEHEPIVLHQYNKVAFDIRETAEVVCKVQAYPKPEFQWQFGNNPSPLTM 683
            ...|.:.::..::.|.::..|......|.|:..:.|...:.|.....|...::|...|...|.|.
Zfish  2590 NATNHLGTSEVTIMLEVDTPPYATSLPNDVSVRVGEVIRLQCLAHGTPPLRYEWTKINGSLPSTA 2654

  Fly   684 SSDGHYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVAN------TLDTIRAPIRLQQKGPPE 742
            ...|               ..|:||....:|.|.|.|..:|      .|..:.....|..|..|:
Zfish  2655 QLQG---------------GDLQINLAKENDAGTYRCVASNKVGKSEALAKVSVRSSLSVKVSPQ 2704

  Fly   743 KPTNLRATEV-----GHNYVSLSWDPGFDGGLSKTKFFVSYRRVAMPREEQLIPDCATLANSNSA 802
            .......:.|     ....:.:.|..  :||:             :|....:......:.|    
Zfish  2705 VEVKALGSAVEFTCAAKGGLQIEWLK--EGGV-------------LPPNHHIKDGILRIEN---- 2750

  Fly   803 WVEVDCQRDIPCKVTALEQHQSYAFK--VKALNPKSDSPYSSEIMVTTKVSRIPPPLQVTYEPNT 865
             :|...:....|:||:..:|...:.|  ::|| ||      .:|.|.|.|..:.....|.:|.:.
Zfish  2751 -LEQSNEGIYTCRVTSQFEHAQDSAKLLIQAL-PK------VKINVRTSVQTVMVGNSVEFECHA 2807

  Fly   866 RTLGIDVGATCLNLVAVVESMVNADSPMAAWEVV--TTMDNLQLSGNGPTHKEKI--IDRIIGAR 926
                                 :....|...|..|  ...|::::.||       |  ||::.   
Zfish  2808 ---------------------IGDPEPTVRWSKVGAPLPDHVEIRGN-------ILRIDQVF--- 2841

  Fly   927 RVGGGRALGHTISEDEDDNG-LNSLALEDENSPTVRVKLCLRTNPEHCG--DYTDAEIGR----P 984
                           |.|:| ....|..|..|....|.|.:::.|:...  :..:..||.    |
Zfish  2842 ---------------ESDSGQYRCTATNDVGSEHSHVVLNIQSLPQIAALPESKEVTIGSDAVLP 2891

  Fly   985 YIA-----------------------EANALATPTLIAIIVSCVVFALFAGLILMFCRCKRNQSK 1026
            .||                       :.:||..|         ||....||..:  |.....|.|
Zfish  2892 CIASGYPVPTITWSKVENDLPPKCRQDGHALTVP---------VVTESDAGTYV--CTAANKQGK 2945

  Fly  1027 KSAAAKDYEMDSVRPSIVAAQQNQAPPPYYPASGLDNKALEHSMDLALSMED-QKTALYA---TQ 1087
            ..|..:....:.|.|..     .|.|..|.....:.|.....|:.:....:: ....|||   ..
Zfish  2946 VEAFTRLNVHERVMPYF-----TQEPLSYLTLPTIKNSYKAFSIKITFRPDNVDGLILYAGMIIY 3005

  Fly  1088 NGYSYHPGSGVVGVGMGGG------VVGVGV-------------------------GGSVVSGMG 1121
            ||.....|:..:..|:.||      .||.|:                         |..||.|..
Zfish  3006 NGQKKTTGADFISFGLLGGRPEFRFDVGSGMATIRYPTPIKLGEFHTVHLYRNQTQGSLVVDGQA 3070

  Fly  1122 GGVGGIGGSGVG--------VNGIPGLS--AHT---------------MPGNEWV--NMGYMENN 1159
            ...|...|...|        |.|.|..|  |.|               :.|:|.:  ::......
Zfish  3071 PVNGTSQGKFKGLDLNEELFVGGYPNYSMLAKTAGLKTGFVGCIKQLIIQGDEVIFKDLDKSSTG 3135

  Fly  1160 YSN---------SNNGGSVNSQDSLWQVKMSAAAVGNQ---------QGMVQAPMNQYVEQQPAY 1206
            .||         .|:|...:|..||::........|:.         ......|....:.:....
Zfish  3136 VSNCPTCKDRPCQNDGTCEDSVASLYKCTCKRGFTGSNCQHHSSLHCHTEACGPDATCINRPSGL 3200

  Fly  1207 GYDPLTHGG----------------YGAVDDYAPYPHLTATPSQVGDEYHNLRNSQNPSRQDYCS 1255
            |||...|.|                :...|.|..||.||           |:.|......:....
Zfish  3201 GYDCRCHLGKSGNKCMDGTLITTPLFDGEDSYIAYPPLT-----------NIHNDLRIEMEFKPM 3254

  Fly  1256 DP-----YASVQKPK-------KRVDQHLDSPYHDVSGLPNPYNMEHLEQDEVLPPQQHMSL 1305
            ||     ::..:|.|       ..|:.|::..|...:|            ..||..|:.:||
Zfish  3255 DPDGLMFFSGGKKMKVEDFVAVSMVNGHVEFRYELGTG------------QAVLRSQEPVSL 3304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
edNP_001260013.1 Ig 50..147 CDD:299845 12/42 (29%)
I-set 146..249 CDD:254352 30/127 (24%)
Ig 168..249 CDD:299845 23/102 (23%)
IGc2 268..323 CDD:197706 19/59 (32%)
Ig_3 341..406 CDD:290638 20/74 (27%)
Ig_2 437..514 CDD:290606 28/89 (31%)
I-set 526..633 CDD:254352 24/114 (21%)
Ig 546..632 CDD:143165 19/89 (21%)
IG_like 654..736 CDD:214653 17/87 (20%)
Ig 656..734 CDD:143165 16/83 (19%)
FN3 741..848 CDD:238020 19/113 (17%)
hspg2XP_021325650.1 SEA 84..198 CDD:321958
LDLa 216..251 CDD:238060
LDLa 277..311 CDD:238060
LDLa 317..351 CDD:238060
LDLa 360..395 CDD:238060
Ig_Perlecan_like 413..490 CDD:143220
Laminin_B 598..732 CDD:306547
EGF_Lam 766..814 CDD:238012
EGF_Lam 831..869 CDD:238012
Laminin_EGF 871..923 CDD:278482
Laminin_B 991..1125 CDD:306547
Laminin_EGF 1159..1206 CDD:278482
EGF_Lam 1208..1261 CDD:238012
Laminin_EGF 1272..1315 CDD:278482
Laminin_B 1536..1671 CDD:306547
EGF_Lam 1705..1754 CDD:238012
EGF_Lam 1755..1811 CDD:238012
IG_like 1823..1903 CDD:214653
Ig_Perlecan_like 1911..1996 CDD:143231
I-set 2025..2109 CDD:254352 11/38 (29%)
I-set 2119..2231 CDD:254352 28/116 (24%)
I-set 2241..2309 CDD:333254 20/69 (29%)
Ig_3 2333..2407 CDD:316449 21/77 (27%)
Ig_3 2427..2500 CDD:316449 26/84 (31%)
I-set 2517..2606 CDD:254352 25/116 (22%)
I-set 2610..2693 CDD:333254 20/97 (21%)
I-set 2699..2778 CDD:333254 14/98 (14%)
I-set 2785..2867 CDD:254352 23/127 (18%)
I-set 2871..2954 CDD:254352 17/93 (18%)
LamG 2961..3119 CDD:238058 30/162 (19%)
EGF_CA <3146..3175 CDD:238011 6/28 (21%)
LamG 3226..3377 CDD:238058 21/102 (21%)
EGF 3402..3433 CDD:306513
EGF_CA 3441..3470 CDD:238011
LamG 3497..3671 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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