Protein Alignment ed and hmcn1

DIOPT Version :10

• Sequence 1: NP_523469.2
• Gene: ed / 33619
• FlyBaseID: FBgn0000547
• Length: 1332
• Species: Drosophila melanogaster
• Sequence 2: XP_073788814.1
• Gene: hmcn1 / 559150
• ZFINID: ZDB-GENE-041014-322
• Length: 5641
• Species: Danio rerio
• Alignment Length: 1067
• Identity: 252/1067 - (23%)
• Similarity: 396/1067 - (37%)
• Gaps: 260/1067 - (24%)

  Fly    87 AIGEVQLSSGYRLDFQPERGIYDLQIKNVSYNRDNGRFEC-RIKAKGTGADVHQEFHNLTVLTPP 150
            |.|...||.|:         :.::....||   |.|.::| .|...|:    .:..::|.|..|
Zfish  1975 AAGVNILSRGH---------VLEIDRAQVS---DAGFYKCVAINVAGS----TELTYSLQVYVP- 2022

  Fly   151 HPPVISPGNIAVATEDKPMELTCSSIGGSPDPTITWYREGSNTPLPATVLKGGTKDQPTNATLSI 215
             |.:.|.|.:.....:.|:.|.|.: .|.|.|::||.:|||    |.:....|.:.......||.
Zfish  2023 -PTISSKGGMVTVVVNDPVRLECEA-SGVPVPSLTWLKEGS----PVSSFSDGIQVLSGGRVLSF 2081

  Fly   216 IPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEVGPENPLRVERDRTAKLECNVDAK 280
            |..:..|...|.||    |:|.|........|.| |.|...:|.|....|...::.:|.|..||.
Zfish  2082 ISAQVSDAGHYTCV----AVNAGGEQHREYELRV-YVPPNIMGEEVNNTVLMGQSVQLHCQSDAI 2141

  Fly   281 PKVPNVRWNRNGRFI----------SSSLVHTIHRVSVQDAGKYTCIADNGLGKTGEQELILDIL 335
            |. |.:.|.::||.:          ..|.:..| ...|||.|:|||.|.|..||| |:...|::.
Zfish  2142 PP-PALSWRKDGRPLYRKPGLSVSEDGSFLKII-SAQVQDTGRYTCEATNVAGKT-EKHYNLNVW 2203

  Fly   336 YPPMV----VIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSP---DFRY----NGDVLTL 389
            .||.:    .:.|.|  ..||..:|:.|..:..|.|..| |.|:.|.   |.|.    .|..|.:
Zfish  2204 VPPSIRGSDEVSSLT--VIEGGLITLVCESSGIPPPSLI-WKKDGSELKGDSRVRVLSGGRQLQI 2265

  Fly   390 TSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITP-------NKPVVHVG 447
            :|.....|.:|.|.|                :|.....::....|.|:.|       ::..|..|
Zfish  2266 SSAEKADASSYTCLA----------------SSAAGSAIKEYNLQVYVRPSISSSAQDEETVTRG 2314

  Fly   448 NGVTLTCSANPPGWPVPQYRWFRDMDGEFSST---QKILAQGPQYSIPKAHLGNEGKYHCHAVNE 509
            ..:||.|.|:  |.|.|...|.:  ||...||   .:||.:|....|.:|.:.:.|:|.|.|:|.
Zfish  2315 GDITLRCEAD--GVPRPAVSWMK--DGRPLSTGRKAQILNEGRLLRILEAQVADTGRYTCIAINV 2375

  Fly   510 LGIGMMATIVLEIHQPPQFLAKLQQHMTRR---VADTDYTVTCSAKGKPAPSVKWLKDAVEILPE 571
            .|.......| .:|.||..:.  |.||...   |......:||.|.|.|.|::.||||...|...
Zfish  2376 AGQADRKYDV-NVHVPPTIIG--QTHMPENISVVVKNPVVLTCEASGMPPPAITWLKDGQPISTS 2437

  Fly   572 ENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRGLYTCLYQNEVNSANSSMQLRIE 636
            .::..:  :..:||..|....|                  |.|.|||:..|.......:..|.:.
Zfish  2438 SSVRVI--SGGRGLRLMHAASS------------------DAGRYTCIVSNSAGEERKNFDLYVL 2482

  Fly   637 HEPIVLHQ--YNKVAFDIRETAEVVCKVQAYPKPEFQWQFGNNP----SPLTMSSDGHYEISTTT 695
            ..|.::::  ...|....|:.|.:.|:|...|.||..|.....|    :.|.:.|:|.:
Zfish  2483 VPPSIVNEGTVEDVKVKERQNAILACEVTGNPVPEITWLKDGQPLASDTRLQVMSNGRF------ 2541

  Fly   696 DNNDIYTSVLKINSLTHSDYGEYTCRVANT---------LDTIRAPIRLQQKGPP---------- 741
                     |:|::...:|.|.|:|..:|:         |:.:.:| .:...||.
Zfish  2542 ---------LQISASQVADTGRYSCLASNSAGDRSRHFNLNVLVSP-TIAGSGPEGSAEEVTVTL 2596

  Fly   742 EKPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYRRVAMPREEQLIPDCATLANSNSAWVEV 806
            ..||:|......:....::|       |.....|.|.|.|      :::|...||...|:.  |.
Zfish  2597 NSPTSLVCEAQSYPPAIITW-------LKDGTPFESSRNV------RVLPGGRTLQILNAK--EE 2646

  Fly   807 DCQRDIPCKVT--ALEQHQSYAFKV---KALNPKSDSPYSS----EIMVTTKVSRIPPPLQVTYE 862
            |..| ..|..|  |.|..::|..||   ..:| |:|.|..|    |:.:  ||:
Zfish  2647 DAGR-YTCVATNEAGETLKNYEVKVFVPPVIN-KNDIPGESLAPKEVKI--KVN----------- 2696

  Fly   863 PNTRTLGIDVGATCLNLVAVVESMVNADSPMAAW----EVVTTMDNLQLSGNGPTHKEKIIDRII 923
             ||.||..:..|              ..:|...|    :::....:|.::.||         ||:
Zfish  2697 -NTLTLECEAQA--------------IPTPTLVWYKDGQILKADGHLTITANG---------RIV 2737

  Fly   924 GARRVGGGRALGHTISEDEDDNG-----LNSLALEDENSPTVRVKL--CLR----TNPEHCGDYT 977
                     .:.||   ...|.|     ..::|.|||....|.:::  ..|    :.|.:.|:..
Zfish  2738 ---------QIKHT---QVSDTGRYTCVATNIAGEDEKDFDVNIQVPPSFRGFGDSGPGNNGEVK 2790

  Fly   978 DAEIGRP--YIAEANALATPTLI------AIIVSCVVFALFAGLILMFCRCKRNQSKK------S 1028
            |..:..|  ...|.||:..|.|.      .:..:..|..|..|.:|...|.:.:.:.:      :
Zfish  2791 DVILNNPISLYCETNAVPPPVLTWYKDGHLLTSNDKVLILPGGRVLQIPRAQVDDTGRYTCVAVN 2855

  Fly  1029 AAAKD---YEMDSVRPSIVAAQQNQAP 1052
            .|.:|   |::..:.|..:.....:.|
Zfish  2856 EAGEDSIQYDVRVLLPPSIRGADGELP 2882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_523469.2	V-set	50..147	CDD:462230	13/60 (22%)
		Ig	153..249	CDD:472250	26/95 (27%)
		Ig strand B	169..173	CDD:409353	1/3 (33%)
		Ig strand C	183..187	CDD:409353	1/3 (33%)
		Ig strand E	211..215	CDD:409353	1/3 (33%)
		Ig strand F	225..230	CDD:409353	2/4 (50%)
		Ig strand G	242..245	CDD:409353	0/2 (0%)
		Ig_3	253..320	CDD:464046	23/76 (30%)
		Ig_3	337..406	CDD:464046	23/79 (29%)
		Ig_2	437..>504	CDD:464026	22/76 (29%)
		Ig	525..635	CDD:472250	28/112 (25%)
		Ig strand B	545..549	CDD:409568	0/3 (0%)
		Ig strand C	558..562	CDD:409568	0/3 (0%)
		Ig strand E	587..591	CDD:409568	1/3 (33%)
		Ig strand F	615..620	CDD:409568	3/4 (75%)
		Ig strand G	628..631	CDD:409568	0/2 (0%)
		Ig_3	639..724	CDD:464046	20/90 (22%)
		FN3	741..848	CDD:238020	29/125 (23%)
hmcn1	XP_073788814.1	None