DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and kirrel3l

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_001092814.2	Gene:	kirrel3l / 557315	ZFINID:	ZDB-GENE-070831-1	Length:	755	Species:	Danio rerio

Alignment Length:	889	Identity:	198/889 - (22%)
Similarity:	314/889 - (35%)	Gaps:	203/889 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 FLIALVALSSTTLA--------DESIDTRENADLTLKCRFNDKYEANDFSFFWTRWTANPAQFDN 85
            |.|||..|.:.:.|        |:.:...::  :||.|.... |..      ..:||.     |.
Zfish     4 FYIALCLLGTVSQAAYFSQQPQDQVVVAGQS--VTLPCVIVG-YRG------MVQWTK-----DG 54

  Fly    86 VAIGEVQLSSG---YRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKAKGTGADVHQEFHNLTVL 147
            :|:|..:...|   |.|...|..|.:.|.|.:.... |:..:||    :.|.|.:......||||
Zfish    55 LALGGERDLPGWVRYSLMGDPLSGEHSLVIDSAELG-DDAIYEC----QATQAGLRSHRAKLTVL 114

  Fly   148 TPPHPPVISPGNIAVATEDKPMELTCSSIGGSPDPTITWYREG---SNTPLPATVLKGGTKDQPT 209
            .||..|::..|.:.......|..|||.:.|..|...|||||:|   .|.....::::.| |.:..
Zfish   115 VPPSDPIVEGGPVVRLKAHTPHNLTCRASGAKPAAEITWYRDGEIMQNAIYSKSLMEDG-KRETA 178

  Fly   210 NATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEVGPENPLRVERDRTAKLE 274
            .:.|.::|...|.|..|.|.|.|.|...|:  :.:.|:||.:.|.|.:..: |..|.........
Zfish   179 VSMLPMVPEDSDSGRTYTCRVLNPAAPAGR--QTSVTINVQHPPSVTLSVQ-PQTVMEGAKVLFI 240

  Fly   275 CNVDAKPKVPNVRWNRNGRFIS----SSLVHTIHRVSVQDAGKYTCIADNGLGKTGEQELILDIL 335
            |:..|.|::...||::.|..||    .||..|.......|  ..:|...|.:|.|....|: |:.
Zfish   241 CSASANPEITGYRWSKGGVPISEANGDSLEVTADHSYFTD--PVSCEVSNSVGSTNVSTLV-DVQ 302

  Fly   336 YPPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYNGDVLTLTSVRADHAGNY 400
            :.|.::.|.|.:..:.|......|:.|.|| |:|:.|.|:.|.....|.:.|.|.:|..|..|.|
Zfish   303 FGPRLLTEPKPQIVDIGMDAAFTCSWTGNP-PLTLAWTKQGSNVVLSNSNTLQLKAVTQDDTGTY 366

  Fly   401 ICRAVNIMQSQGMERSERVG--NSTVALLVRHRPGQAYITPNKPVVH-VGNGVTLTCSANPPGWP 462
            .|:|:          ..|:|  ...|.|.|...|........:.:.| .|....|..|:.||...
Zfish   367 TCKAI----------VPRIGVAERDVTLTVNGPPIITAEATQQAIKHSKGKLECLVGSSPPPDKI 421

  Fly   463 VPQYRW-FRDM------DGEFS-----STQKI---------LAQGPQYSIPKAHLGNEGKYHCHA 506
            |    | |.||      .|.||     |.|.:         |||..|.           :|:|.|
Zfish   422 V----WTFGDMMLSSGSSGRFSVQTVNSDQGVLSSLILSETLAQDFQL-----------RYNCTA 471

  Fly   507 VNELGIGMMATIVLEIHQPPQFLAKLQQHMTRR-----VADTDYTVTC--SAKGKPAPSVKWLKD 564
            .|..|.| .|.:.||..:....|..:...:...     ...|..::.|  :||||....:.....
Zfish   472 WNRFGTG-TALVTLEEQEALPLLIIIGASVGGGCVFIVCVITLVSICCRHNAKGKKGTRLSKSDI 535

  Fly   565 AVEILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRGLYTCLYQNEVNSANS 629
            .|:|:..::      |..:|.:....|:             ..:.|              ||:.|
Zfish   536 RVQIVHSDH------NAARGNDDEEDVK-------------EPMAP--------------NSSES 567

  Fly   630 SMQLRIEHEPIVLHQYNKVAFDIRETAEVVCKVQAYPKPEFQWQFGNNPSPLTMSSDGHYEISTT 694
            ....|.||..: |.:.:....||::                             .::|:|.:...
Zfish   568 PGTSRTEHSDL-LEEEDDERSDIKD-----------------------------PTNGYYNVRAH 602

  Fly   695 TDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIRAPIRLQQKGP--PEKPTNLRATEVGHNYV 757
            .|.:           :|.:.:.||    ||....:..|.:|....|  .:..|..|..:....|.
Zfish   603 EDRH-----------ITRTGFSEY----ANNARPVYTPTQLPSPSPLYGQHSTQPRIYDFSQRYA 652

  Fly   758 SLSWDPGFDGGLSKTKFFVSYRRVAMPREEQLIPDCAT-----LANSNSAWVEVDCQRDIP--CK 815
            :..        .::|.:     ....|::.|..|...|     ...|.|.::.....|...  .|
Zfish   653 TTP--------ANRTTY-----EQQQPQQPQQQPQTPTAYPQETVYSGSTYLPATYGRAFTSYVK 704

  Fly   816 VTALEQHQSYAFKVKALNPKSDSPYS-SEIMVTTKVSRIPPPLQ 858
            ..:.|:...|....:|....|.|.:| :...|:::.|....|.|
Zfish   705 PASYEKVDGYEHSDQASKVSSSSRFSYASSQVSSQQSDYGRPSQ 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	23/99 (23%)
		I-set	146..249	CDD:254352	32/105 (30%)
		Ig	168..249	CDD:299845	26/83 (31%)
		IGc2	268..323	CDD:197706	14/58 (24%)
		Ig_3	341..406	CDD:290638	21/64 (33%)
		Ig_2	437..514	CDD:290606	25/98 (26%)
		I-set	526..633	CDD:254352	16/113 (14%)
		Ig	546..632	CDD:143165	14/87 (16%)
		IG_like	654..736	CDD:214653	9/81 (11%)
		Ig	656..734	CDD:143165	9/77 (12%)
		FN3	741..848	CDD:238020	19/114 (17%)
kirrel3l	NP_001092814.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582428
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840