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Protein Alignment ed and KIRREL1

DIOPT Version :10

Sequence 1:	NP_523469.2	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	752	Identity:	163/752 - (21%)
Similarity:	261/752 - (34%)	Gaps:	207/752 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 WTRWTANPAQFDNVAIGEVQLSSG------YRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKAK 131
            ||:        |.:|:|   :..|      ||:....:.|.|:|:|.:...: |:..:||    :
Human    53 WTK--------DGLALG---MGQGLKAWPRYRVVGSADAGQYNLEITDAELS-DDASYEC----Q 101

  Fly   132 GTGADVHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTCSSIGGSPDPTITWYREGS---NT 193
            .|.|.:......||||.||....|..|.:.:.....|..|||.:....|..||.|:|:|:   ..
Human   102 ATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGA 166

  Fly   194 PLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEVG 258
            .....:||.| |.:.|.:.|.|.|...|.|..:.|...|.|:..||  |.:..|:|::.|.|.:.
Human   167 VASTELLKDG-KRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGK--ETSIELDVHHPPTVTLS 228

  Fly   259 PENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYT----CIAD 319
            .| |..|:........|...|.|::...||.:.|..|..:  |.....:..|...:|    |...
Human   229 IE-PQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDA--HESRYETNVDYSFFTEPVSCEVH 290

  Fly   320 NGLGKTGEQELILDILYPPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENS------- 377
            |.:|.|....|: ::.:.|.:|::.|....:.|..||:.|....|| |:|:.|.|::|
Human   291 NKVGSTNVSTLV-NVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNP-PLTLTWTKKDSNMGPRPP 353

  Fly   378 ---PDFRYNGDVLT------LTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPG 433
               |:...:..||:      |.||....||.|.|||:          ..|:|       |..|..
Human   354 GSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAI----------VPRIG-------VAEREV 401

  Fly   434 QAYITPNKPVVHVGNGVTLTCSANPPGWPVPQYRWFRDMDGEFSSTQKILAQGPQYSIPKAHLGN 498
            ..|:          ||        ||                     .|.::..||::    .|:
Human   402 PLYV----------NG--------PP---------------------IISSEAVQYAV----RGD 423

  Fly   499 EGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTRRVADTDYTVTCSAKGKPAPSVKWLK 563
            .||..|.      ||..        .||..:|                            ..|.:
Human   424 GGKVECF------IGST--------PPPDRIA----------------------------WAWKE 446

  Fly   564 DAVEILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPN---GNALVPGDRGLYTCLYQNEVN 625
            :.:|:...|.....:||...|:...:|:.:.::...:...|   .|:..||     |.:.|.|..
Human   447 NFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPG-----TAIIQLEER 506

  Fly   626 -----------SANSSMQLRIEHEPIVLHQYNKVAFDIRETA--EVVCKVQAYPKPEFQWQFGNN 677
                       :..:|:.|......:|...|.:.....::..  ::..||:..           |
Human   507 EVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETV-----------N 560

  Fly   678 PSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIRAPIRLQQKGPPE 742
            ..||||.||      ...|...:.|:...:.::..|...:...:.....|||......:.|.|..
Human   561 REPLTMHSD------REDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTN 619

  Fly   743 KPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYR 779
            ...|:||.|              |...|:...:..||
Human   620 GYYNVRAHE--------------DRPSSRAVLYADYR 642

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.