DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and KIRREL1

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	752	Identity:	163/752 - (21%)
Similarity:	261/752 - (34%)	Gaps:	207/752 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 WTRWTANPAQFDNVAIGEVQLSSG------YRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKAK 131
            ||:        |.:|:|   :..|      ||:....:.|.|:|:|.:...: |:..:||    :
Human    53 WTK--------DGLALG---MGQGLKAWPRYRVVGSADAGQYNLEITDAELS-DDASYEC----Q 101

  Fly   132 GTGADVHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTCSSIGGSPDPTITWYREGS---NT 193
            .|.|.:......||||.||....|..|.:.:.....|..|||.:....|..||.|:|:|:   ..
Human   102 ATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGA 166

  Fly   194 PLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEVG 258
            .....:||.| |.:.|.:.|.|.|...|.|..:.|...|.|:..||  |.:..|:|::.|.|.:.
Human   167 VASTELLKDG-KRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGK--ETSIELDVHHPPTVTLS 228

  Fly   259 PENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYT----CIAD 319
            .| |..|:........|...|.|::...||.:.|..|..:  |.....:..|...:|    |...
Human   229 IE-PQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDA--HESRYETNVDYSFFTEPVSCEVH 290

  Fly   320 NGLGKTGEQELILDILYPPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENS------- 377
            |.:|.|....|: ::.:.|.:|::.|....:.|..||:.|....|| |:|:.|.|::|
Human   291 NKVGSTNVSTLV-NVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNP-PLTLTWTKKDSNMGPRPP 353

  Fly   378 ---PDFRYNGDVLT------LTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPG 433
               |:...:..||:      |.||....||.|.|||:          ..|:|       |..|..
Human   354 GSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAI----------VPRIG-------VAEREV 401

  Fly   434 QAYITPNKPVVHVGNGVTLTCSANPPGWPVPQYRWFRDMDGEFSSTQKILAQGPQYSIPKAHLGN 498
            ..|:          ||        ||                     .|.::..||::    .|:
Human   402 PLYV----------NG--------PP---------------------IISSEAVQYAV----RGD 423

  Fly   499 EGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTRRVADTDYTVTCSAKGKPAPSVKWLK 563
            .||..|.      ||..        .||..:|                            ..|.:
Human   424 GGKVECF------IGST--------PPPDRIA----------------------------WAWKE 446

  Fly   564 DAVEILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPN---GNALVPGDRGLYTCLYQNEVN 625
            :.:|:...|.....:||...|:...:|:.:.::...:...|   .|:..||     |.:.|.|..
Human   447 NFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPG-----TAIIQLEER 506

  Fly   626 -----------SANSSMQLRIEHEPIVLHQYNKVAFDIRETA--EVVCKVQAYPKPEFQWQFGNN 677
                       :..:|:.|......:|...|.:.....::..  ::..||:..           |
Human   507 EVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETV-----------N 560

  Fly   678 PSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIRAPIRLQQKGPPE 742
            ..||||.||      ...|...:.|:...:.::..|...:...:.....|||......:.|.|..
Human   561 REPLTMHSD------REDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTN 619

  Fly   743 KPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYR 779
            ...|:||.|              |...|:...:..||
Human   620 GYYNVRAHE--------------DRPSSRAVLYADYR 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	19/79 (24%)
		I-set	146..249	CDD:254352	33/105 (31%)
		Ig	168..249	CDD:299845	27/83 (33%)
		IGc2	268..323	CDD:197706	12/58 (21%)
		Ig_3	341..406	CDD:290638	25/80 (31%)
		Ig_2	437..514	CDD:290606	12/76 (16%)
		I-set	526..633	CDD:254352	17/120 (14%)
		Ig	546..632	CDD:143165	15/99 (15%)
		IG_like	654..736	CDD:214653	15/83 (18%)
		Ig	656..734	CDD:143165	15/79 (19%)
		FN3	741..848	CDD:238020	8/39 (21%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352	18/78 (23%)
		Ig	25..116	CDD:299845	18/78 (23%)
		Ig2_KIRREL3-like	138..219	CDD:143236	27/83 (33%)
		I-set	223..304	CDD:254352	20/84 (24%)
		Ig_2	227..305	CDD:290606	18/81 (22%)
		Ig_2	311..405	CDD:290606	29/111 (26%)
		IG_like	314..405	CDD:214653	28/108 (26%)
		Ig5_KIRREL3	407..504	CDD:143306	28/176 (16%)
		IG_like	416..504	CDD:214653	24/138 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148513
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840