DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and CG45263

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster

Alignment Length:	1570	Identity:	316/1570 - (20%)
Similarity:	510/1570 - (32%)	Gaps:	441/1570 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RKTTTKGTAIVNSRSARRAATTICNFFLIALVALSSTTLADESID--------TREN--ADLTLK 57
            ::::...::|..|.|:..::|.|....|:..:|::|.....|...        |..|  .|..|.
  Fly     8 KRSSRSRSSISTSISSSGSSTKIAQLLLLIGIAVASCLPGSEGFQRFSEQPKYTEVNPAEDTLLT 72

  Fly    58 CRFNDK------YEANDFSFFWTR---WTANPAQFDNVAIGEVQLSSGYRLDFQPE----RGIYD 109
            |:..||      .:.|.....:|:   |.:.....||   |.|     ..||..|.    .|...
  Fly    73 CKVIDKRGTCSWQKDNKPVGIYTKKYEWASRMPTSDN---GNV-----LHLDLHPPPVQLGGDCS 129

  Fly   110 LQIKNVSYNRDNGRFECRIKAKG-TGAD--VHQEFHNLTVLTPPHPPV------ISPGNIAVATE 165
            |.|::.:.:.|:|.:||::.|.. |..|  ..|....:..:.|..|.:      :.||:...|..
  Fly   130 LWIRSATLDFDDGLWECQVTASDFTTQDALTSQPVRLVVRVAPQRPRLEYEAVHVPPGHNITADA 194

  Fly   166 DKPMELTCSSIGGSPDPTITWYREGSNTPLPATVLKGGTK-DQP----TNATLSIIPRREDDGAK 225
            .....:.|.|..|:|..|:.|:. |.....|.......|: |.|    ..:.:.:...||..|..
  Fly   195 GALATVKCISHYGNPPATLKWFL-GDQEISPIHPQMNATEPDNPRTWSATSVVQVSAMRERHGDI 258

  Fly   226 YKCVVRNRAMNEGKRLEATATLNVNYYPRVEV--GPENPLRVERDRTAKLECNVDAKPKVPNVRW 288
            .:|...:.:.. .|.:...|.|:|.|.|.:.:  .||..|..::|... |.|..||.|.. ::.|
  Fly   259 LRCAAYHESYT-AKSVVVEARLDVKYAPSIRLIGSPEIDLEEDKDALV-LRCVADANPPA-SIVW 320

  Fly   289 NRNGRFISSSLVHT--IHRVSVQDAGKYTCIADNGLGKTGEQELILDILYPPMVVIESKTR--EA 349
            .|.||...:||..|  :..|..:|||.|||.|.|.:|.:.:..:.||:.|||.::.....|  .|
  Fly   321 RRAGRSEIASLQETLQLRPVGRRDAGLYTCQAQNSVGTSEQLSVQLDVKYPPKIISAGPDRLTTA 385

  Fly   350 EEGDTVTIRCNVTANPAPVTIEWLKENSPDFRY----NGDVLTLTSVRADHAGNYICRAVNIMQS 410
            .........|....||.| :.:|::..:...:|    :...|.:.:|..::.|.|.|||.:.:..
  Fly   386 PLFSPAAFECLADGNPLP-SFKWVQRMAHGSKYVERGSESRLVIDNVTYEYQGEYECRATSYING 449

  Fly   411 QGMERSERVG-NSTVALLVRHRPGQAYITPNKPVVHVGNG----VTLTCSANPPGWPVPQ---YR 467
            |     |||. :..|:|.|...|....:.|:...|.|..|    :|:...|:|.    ||   :.
  Fly   450 Q-----ERVAISDPVSLQVVGAPQVLRLHPSLHTVSVKRGEAASLTMVVCADPR----PQRVAWE 505

  Fly   468 W-------------FR--DMDGE-----FSSTQKIL-----AQGPQYSIPKAHLGNEGKYHCHAV 507
            |             ||  ||..:     :.||..||     ...|.|.:.:...|.: ::..|.:
  Fly   506 WGSLRLEAGSGIDRFRADDMQPDTREDCYLSTLHILHADEHDSRPYYLVVENERGTD-RHAIHLI 569

  Fly   508 NE------------LGI--GMMATIVLEI------------------------------------ 522
            .|            :|:  |.||.|:|.:
  Fly   570 VEGTFAEPYEMSYLMGVAGGCMAAILLLVCLCIYAIKSKRCCFKGSTGYKSSDKDSEKADLKSRS 634

  Fly   523 --------------------HQPPQFLAKLQQHMTRRVADTDYTVTCSAK----GKPAPSVKWLK 563
                                ||..|...:.|||.....|...:..:...:    |..:|....::
  Fly   635 DSTSGPQGDSIYTTPAGFHHHQQQQQQQQQQQHAAAAAAAALHAASQHPQQQYPGHGSPEAMKVR 699

  Fly   564 DAVEIL--PEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRGLYTCLYQNEVNS 626
            .|..||  |... ..:.|..:.  |..:|.|.|.........|.|.            :|||:..
  Fly   700 MAAMILQPPTRVXQAIDTTSES--NEQLTQQQQQDDNKNKNKNENE------------HQNELTD 750

  Fly   627 ANSSMQLRIEHEPIVLHQYNKVAFDIRETAEVVCKVQAYPKPEFQWQFGNNPSPLTMSSDGHYEI 691
            .:::...:...:..|.|..|. ...|..|:..|.....          .||.|.:..:||
  Fly   751 QHTTSNEQRLDDSSVSHNNNN-NHKISSTSTTVLTNSD----------NNNTSEVAKASD----- 799

  Fly   692 STTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIRAPIRL------------QQKGP---- 740
            |:.::.....||     |.|.|...:....:...:....||..|            ||.||
  Fly   800 SSNSEGGSSLTS-----SKTSSSKRDLENNMNRDIKPATAPKLLHLNVTSGEQQEHQQPGPVDPL 859

  Fly   741 PEKPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYRRVAMPREEQLIPDCATLANSNSAWVE 805
            |..|.....|:|....:|:: :|           |..:|     ::...:.:......|::..|.
  Fly   860 PVGPLTPEETQVLLQKLSIN-NP-----------FYRFR-----KQSNSLKELRRKTGSDAPSVR 907

  Fly   806 VDCQRDI-PCKVTALEQHQ--SYAFKVKALNPKS-----DSPYSSEIMVTTKVSRIPPPLQVTYE 862
            ...:.|: ..:...|..||  |.|..|..|:.|.     ..|.||..:.|..||.:        .
  Fly   908 SRSETDLGQVRGQQLMPHQQHSEAKVVVVLDSKQKEVAISRPRSSVSLKTRSVSSL--------S 964

  Fly   863 PNTRTLGIDVGATCLNLVAVVESMVNADSPMAAW---EVVTTMDNLQL--SGNGPTHKEKIIDRI 922
            |:|..:|              :|.....:|.:.:   |::|...|.:|  :.|..:.:.:...|
  Fly   965 PSTNQMG--------------DSSTVITNPFSIFHDDEILTLSVNTRLRSAANARSSRPQRQGR- 1014

  Fly   923 IGARRVGGGRALGHTISEDEDDNGLNSLALE----DENSPTVRVKLCLRTNPEHCGDYTDAEIGR 983
             |.||:.......:..||....:|:.....|    |.:|..:            .|..|:...|:
  Fly  1015 -GLRRLFESNRSQNPPSEHHYLHGVPVRRFERQDFDNDSGDL------------LGRRTNTSSGK 1066

  Fly   984 PYIAEANALATPTLIAIIVSCVVFALFAGLILMFCRCKRNQSKKSAAAKDYEMDSVRPSIVAAQQ 1048
            |..:.                   |:|..|.|      |....::||.:
  Fly  1067 PKRSR-------------------AIFKQLSL------RKLHNRAAAEE---------------- 1090

  Fly  1049 NQAPPPYYPASGLDNKALEHSMDLALSMEDQKTALYATQNGYSYHP-----GSGVVGVGMGGGVV 1108
                ||..|...|......||:.   ||.......|..|:..:|||     .|.|........:.
  Fly  1091 ----PPSLPKLKLSYPNRTHSIQ---SMRASGGGGYDIQHTTAYHPRLNHSTSPVTKANYFERLQ 1148

  Fly  1109 GVGVGG-----------SVVSGMGGGVGGIGGSGVGVNGIPGLSAHTMPGNEWVNM--------- 1153
            .....|           ...:|.||.:||...||.          ||:..:|....
  Fly  1149 AKTRQGIQKIRDKCRNFKTTTGEGGSLGGSEFSGF----------HTLAKDESFRFISDRANISS 1203

  Fly  1154 ----------------------------GYMENNYSNSNNGGSVNSQDSLWQVKMSAAAVGNQQG 1190
                                        .|:|.|:.:           .|...|.||.:||...|
  Fly  1204 YESRCKQATIYKSYKSEIDLSKNLHYLDAYLEQNFDH-----------QLSTTKQSAHSVGRVSG 1257

  Fly  1191 MVQAPMNQYVEQQPAYGYDPLTHGGYGAVDDY-APYPHLTATPSQVGDEYHNLR-NSQNPSRQDY 1253
            ..:..:.:..:..|.....|..........:| |.|.:|...|.....:..|.. ||.:.|..||
  Fly  1258 AQRKALAKQHDPTPETPRPPRHKRSQSQAANYGANYENLGTLPIASKSKVRNTALNSDSMSSSDY 1322

  Fly  1254 C---SDPYASVQKPK------KRVDQHLDSP---YHDVSGLPNPYNMEHLEQDEVLPPQQHMS-- 1304
            .   |.|..:.|:|:      |...:|.|..   |.|  .|.: |.:...|.:::|..:...|
  Fly  1323 ASVFSGPTTNRQEPEEDPKDFKLRYEHPDKMCEYYFD--NLTS-YALALEESEDLLLAESAKSAR 1384

  Fly  1305 LSYDDSFEGE 1314
            ..|||..|.:
  Fly  1385 FFYDDDEEDD 1394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	27/114 (24%)
		I-set	146..249	CDD:254352	23/113 (20%)
		Ig	168..249	CDD:299845	18/85 (21%)
		IGc2	268..323	CDD:197706	22/56 (39%)
		Ig_3	341..406	CDD:290638	15/70 (21%)
		Ig_2	437..514	CDD:290606	24/122 (20%)
		I-set	526..633	CDD:254352	21/112 (19%)
		Ig	546..632	CDD:143165	16/91 (18%)
		IG_like	654..736	CDD:214653	16/93 (17%)
		Ig	656..734	CDD:143165	14/77 (18%)
		FN3	741..848	CDD:238020	22/114 (19%)
CG45263	NP_731246.2	I-set	53..149	CDD:254352	24/103 (23%)
		Ig	198..281	CDD:299845	18/84 (21%)
		IG_like	302..368	CDD:214653	24/67 (36%)
		IGc2	302..357	CDD:197706	22/56 (39%)
		Ig	372..446	CDD:299845	16/74 (22%)
		Ig	475..568	CDD:299845	20/97 (21%)
		IG_like	478..570	CDD:214653	21/96 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010