DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and NPHS1

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_004637.1	Gene:	NPHS1 / 4868	HGNCID:	7908	Length:	1241	Species:	Homo sapiens

Alignment Length:	961	Identity:	233/961 - (24%)
Similarity:	354/961 - (36%)	Gaps:	231/961 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IKAKGTGADVHQEFHN------------LTVLTPPHPPVISPGNIAVATEDKPMELTCSSIGGSP 180
            ::.:..||.:..|.||            |.|..||...:|.  ..|..||:|.:.|:|.|....|
Human   306 VRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIIL--GSASQTENKNVTLSCVSKSSRP 368

  Fly   181 DPTITWYREGSN-TPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEAT 244
            ...:.|:..... .|:..||:.|......:.:.|:.:.||||:|....|...:.|..: :..:.:
Human   369 RVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTK-ETFKKS 432

  Fly   245 ATLNVNYYPRVEV---GPENPLRVERDRTAKLEC-NVDAKPKVPNVRWNRNGRFISSSLV----H 301
            ..|||. ||..::   ||....::......:|.| .:...|: |::.|.::.|.::.|.:    .
Human   433 LILNVK-YPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPE-PSLMWYKDSRTVTESRLPQESR 495

  Fly   302 TIHRVSVQDAG------------------KYTCIADNGLGKTGEQELILDILYPPM-VVIESKTR 347
            .:|..||:.:|                  |:||.|......|.     |.:.:||. |.|.:...
Human   496 RVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQ-----LAVQFPPTNVTILANAS 555

  Fly   348 EAEEGDTVTIRC-NVTANPAPVTIEWLKEN-------SPDFR--YNG-----DVLTLTSVRADHA 397
            ....||.:.:.| :|::|| ||.:.|.||.       :|..|  :.|     .||...|.| ||.
Human   556 ALRPGDALNLTCVSVSSNP-PVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSR-DHG 618

  Fly   398 GNYICRAVNIMQSQGMERSERVGNSTVALLVRHRP---GQAYITPNKPVVHVGNGVTL---TCSA 456
            ....|||      ...|..|.| :|...|.|.:||   |:..:.    |..|..|..|   :.||
Human   619 QRVTCRA------HSAELRETV-SSFYRLNVLYRPEFLGEQVLV----VTAVEQGEALLPVSVSA 672

  Fly   457 NPPGWPVPQ-YRWFRDMDGEFSSTQKILAQGPQYSIPKA---HLGN-----EGKYHCHAVNELGI 512
            |    |.|: :.|      .|...:...|.||::.|..:   ||.|     :|.|..|..|..|.
Human   673 N----PAPEAFNW------TFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGT 727

  Fly   513 GMMATIVLEIHQPPQFLAKLQQHMTRRVADTDYTVTCSAKGKPAPSVKWLKDAVEILPE----EN 573
            . .|.:.|::|..|...| ||......|..: ..:.|:.            ||..|||.    |.
Human   728 A-EARLRLDVHYAPTIRA-LQDPTEVNVGGS-VDIVCTV------------DANPILPGMFNWER 777

  Fly   574 LYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVP----GDRGLYTCLYQNEV-NSANSSMQL 633
            |.|  ...||.|:.|..:.     ||   |.|...:.    ...|.|.|:..|.| ..|...::|
Human   778 LGE--DEEDQSLDDMEKIS-----RG---PTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRL 832

  Fly   634 RIEHEPIVLH--QYNKVAF--DIRETAEVVCKVQAYPKPEFQWQFGNNPSPLTMSSDGHYEISTT 694
            .:...|.|.|  ...|||.  |...:|.:.|:.:..|...|.|.  .|..||.:....:.|  .|
Human   833 VVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWT--KNGVPLDLQDPRYTE--HT 893

  Fly   695 TDNNDIYTSVLKI-NSLTHSDYGEYTCRVANTLDTIRAPIRLQQKGPPEKPTNLRATEVGHNYVS 758
            .....:::|:|.| |.....||..:||...|.|.:.:..|:|.....|:.|:.|:...:..:.|.
Human   894 YHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVG 958

  Fly   759 LSWDPGFDGGLSKTKFFVSYRRVAMP--REEQLIPDCATLANSNSAWVEVDCQRDIPCKVTALEQ 821
            |.|.|||||||.: :|.:.|..:..|  ....::|..||...                 :|.|:.
Human   959 LEWKPGFDGGLPQ-RFCIRYEALGTPGFHYVDVVPPQATTFT-----------------LTGLQP 1005

  Fly   822 HQSYAFKVKALNPKSDSPYS---SEIMVTTKVSRIP---PPLQVTYEPNTRTLGIDVGATCLNLV 880
            ...|...:.|.|...||..:   :::.:||.....|   |..|:..||.:...|:
Human  1006 STRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSGL---------- 1060

  Fly   881 AVVESMVNADSPMAAWEVVTTMDNLQLSGNGPTHKEKIIDRIIGARRVGGGRALGHTISE----- 940
                       |:.  .|:..:..|.|..|.     ..:..::..||:   |.|...|||
Human  1061 -----------PLL--PVLFALGGLLLLSNA-----SCVGGVLWQRRL---RRLAEGISEKTEAG 1104

  Fly   941 DEDDNGLNS------LALEDENSPTVRVKLCLRTNPEHCGDYTDAEIGRPY 985
            .|:|...|.      ....|..|.||..              |:||   ||
Human  1105 SEEDRVRNEYEESQWTGERDTQSSTVST--------------TEAE---PY 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	6/30 (20%)
		I-set	146..249	CDD:254352	26/103 (25%)
		Ig	168..249	CDD:299845	18/81 (22%)
		IGc2	268..323	CDD:197706	15/77 (19%)
		Ig_3	341..406	CDD:290638	24/79 (30%)
		Ig_2	437..514	CDD:290606	23/88 (26%)
		I-set	526..633	CDD:254352	28/115 (24%)
		Ig	546..632	CDD:143165	23/94 (24%)
		IG_like	654..736	CDD:214653	21/82 (26%)
		Ig	656..734	CDD:143165	20/78 (26%)
		FN3	741..848	CDD:238020	26/111 (23%)
NPHS1	NP_004637.1	V-set	38..119	CDD:284989
		IG_like	38..113	CDD:214653
		C2-set_2	141..228	CDD:285423
		Ig	240..321	CDD:299845	3/14 (21%)
		IG_like	254..336	CDD:214653	6/29 (21%)
		Ig	345..424	CDD:299845	21/80 (26%)
		Ig	445..530	CDD:299845	16/85 (19%)
		I-set	446..541	CDD:254352	19/100 (19%)
		Ig	549..632	CDD:299845	25/90 (28%)
		IG_like	558..642	CDD:214653	28/92 (30%)
		I-set	646..736	CDD:254352	27/104 (26%)
		Ig	662..736	CDD:299845	23/84 (27%)
		Ig_3	739..820	CDD:290638	25/104 (24%)
		IG_like	748..821	CDD:214653	21/95 (22%)
		Ig8_hNephrin_like	834..942	CDD:143250	29/111 (26%)
		IG_like	845..935	CDD:214653	25/93 (27%)
		fn3	942..1023	CDD:278470	24/98 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1057		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1099..1137		11/54 (20%)
		Binds to NPHS2	1160..1241
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910