DRSC/TRiP Functional Genomics Resources

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Protein Alignment ed and NPHS1

DIOPT Version :10

Sequence 1:NP_523469.2 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster
Sequence 2:NP_004637.1 Gene:NPHS1 / 4868 HGNCID:7908 Length:1241 Species:Homo sapiens


Alignment Length:961 Identity:233/961 - (24%)
Similarity:354/961 - (36%) Gaps:231/961 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 IKAKGTGADVHQEFHN------------LTVLTPPHPPVISPGNIAVATEDKPMELTCSSIGGSP 180
            ::.:..||.:..|.||            |.|..||...:|.  ..|..||:|.:.|:|.|....|
Human   306 VRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIIL--GSASQTENKNVTLSCVSKSSRP 368

  Fly   181 DPTITWYREGSN-TPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEAT 244
            ...:.|:..... .|:..||:.|......:.:.|:.:.||||:|....|...:.|..: :..:.:
Human   369 RVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTK-ETFKKS 432

  Fly   245 ATLNVNYYPRVEV---GPENPLRVERDRTAKLEC-NVDAKPKVPNVRWNRNGRFISSSLV----H 301
            ..|||. ||..::   ||....::......:|.| .:...|: |::.|.::.|.::.|.:    .
Human   433 LILNVK-YPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPE-PSLMWYKDSRTVTESRLPQESR 495

  Fly   302 TIHRVSVQDAG------------------KYTCIADNGLGKTGEQELILDILYPPM-VVIESKTR 347
            .:|..||:.:|                  |:||.|......|.     |.:.:||. |.|.:...
Human   496 RVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQ-----LAVQFPPTNVTILANAS 555

  Fly   348 EAEEGDTVTIRC-NVTANPAPVTIEWLKEN-------SPDFR--YNG-----DVLTLTSVRADHA 397
            ....||.:.:.| :|::|| ||.:.|.||.       :|..|  :.|     .||...|.| ||.
Human   556 ALRPGDALNLTCVSVSSNP-PVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSR-DHG 618

  Fly   398 GNYICRAVNIMQSQGMERSERVGNSTVALLVRHRP---GQAYITPNKPVVHVGNGVTL---TCSA 456
            ....|||      ...|..|.| :|...|.|.:||   |:..:.    |..|..|..|   :.||
Human   619 QRVTCRA------HSAELRETV-SSFYRLNVLYRPEFLGEQVLV----VTAVEQGEALLPVSVSA 672

  Fly   457 NPPGWPVPQ-YRWFRDMDGEFSSTQKILAQGPQYSIPKA---HLGN-----EGKYHCHAVNELGI 512
            |    |.|: :.|      .|...:...|.||::.|..:   ||.|     :|.|..|..|..|.
Human   673 N----PAPEAFNW------TFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGT 727

  Fly   513 GMMATIVLEIHQPPQFLAKLQQHMTRRVADTDYTVTCSAKGKPAPSVKWLKDAVEILPE----EN 573
            . .|.:.|::|..|...| ||......|..: ..:.|:.            ||..|||.    |.
Human   728 A-EARLRLDVHYAPTIRA-LQDPTEVNVGGS-VDIVCTV------------DANPILPGMFNWER 777

  Fly   574 LYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVP----GDRGLYTCLYQNEV-NSANSSMQL 633
            |.|  ...||.|:.|..:.     ||   |.|...:.    ...|.|.|:..|.| ..|...::|
Human   778 LGE--DEEDQSLDDMEKIS-----RG---PTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRL 832

  Fly   634 RIEHEPIVLH--QYNKVAF--DIRETAEVVCKVQAYPKPEFQWQFGNNPSPLTMSSDGHYEISTT 694
            .:...|.|.|  ...|||.  |...:|.:.|:.:..|...|.|.  .|..||.:....:.|  .|
Human   833 VVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWT--KNGVPLDLQDPRYTE--HT 893

  Fly   695 TDNNDIYTSVLKI-NSLTHSDYGEYTCRVANTLDTIRAPIRLQQKGPPEKPTNLRATEVGHNYVS 758
            .....:::|:|.| |.....||..:||...|.|.:.:..|:|.....|:.|:.|:...:..:.|.
Human   894 YHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVG 958

  Fly   759 LSWDPGFDGGLSKTKFFVSYRRVAMP--REEQLIPDCATLANSNSAWVEVDCQRDIPCKVTALEQ 821
            |.|.|||||||.: :|.:.|..:..|  ....::|..||...                 :|.|:.
Human   959 LEWKPGFDGGLPQ-RFCIRYEALGTPGFHYVDVVPPQATTFT-----------------LTGLQP 1005

  Fly   822 HQSYAFKVKALNPKSDSPYS---SEIMVTTKVSRIP---PPLQVTYEPNTRTLGIDVGATCLNLV 880
            ...|...:.|.|...||..:   :::.:||.....|   |..|:..||.:...|:          
Human  1006 STRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSGL---------- 1060

  Fly   881 AVVESMVNADSPMAAWEVVTTMDNLQLSGNGPTHKEKIIDRIIGARRVGGGRALGHTISE----- 940
                       |:.  .|:..:..|.|..|.     ..:..::..||:   |.|...|||     
Human  1061 -----------PLL--PVLFALGGLLLLSNA-----SCVGGVLWQRRL---RRLAEGISEKTEAG 1104

  Fly   941 DEDDNGLNS------LALEDENSPTVRVKLCLRTNPEHCGDYTDAEIGRPY 985
            .|:|...|.      ....|..|.||..              |:||   ||
Human  1105 SEEDRVRNEYEESQWTGERDTQSSTVST--------------TEAE---PY 1138

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
edNP_523469.2 V-set 50..147 CDD:462230 6/30 (20%)
Ig 153..249 CDD:472250 23/96 (24%)
Ig strand B 169..173 CDD:409353 1/3 (33%)
Ig strand C 183..187 CDD:409353 0/3 (0%)
Ig strand E 211..215 CDD:409353 1/3 (33%)
Ig strand F 225..230 CDD:409353 1/4 (25%)
Ig strand G 242..245 CDD:409353 0/2 (0%)
Ig_3 253..320 CDD:464046 18/92 (20%)
Ig_3 337..406 CDD:464046 27/84 (32%)
Ig_2 437..>504 CDD:464026 20/78 (26%)
Ig 525..635 CDD:472250 29/118 (25%)
Ig strand B 545..549 CDD:409568 0/3 (0%)
Ig strand C 558..562 CDD:409568 0/3 (0%)
Ig strand E 587..591 CDD:409568 1/3 (33%)
Ig strand F 615..620 CDD:409568 2/4 (50%)
Ig strand G 628..631 CDD:409568 0/2 (0%)
Ig_3 639..724 CDD:464046 25/89 (28%)
FN3 741..848 CDD:238020 26/111 (23%)
NPHS1NP_004637.1 V-set 38..119 CDD:462230
C2-set_2 141..228 CDD:400489
Ig strand B 156..160 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 200..204 CDD:409353
Ig strand F 214..219 CDD:409353
Ig strand G 229..232 CDD:409353
Ig 237..336 CDD:472250 6/29 (21%)
Ig strand B 261..265 CDD:409353
Ig strand C 275..279 CDD:409353
Ig strand E 300..304 CDD:409353
Ig strand F 314..319 CDD:409353 0/4 (0%)
Ig strand G 332..335 CDD:409353 0/2 (0%)
Ig 345..424 CDD:472250 21/80 (26%)
Ig strand B 357..361 CDD:409353 1/3 (33%)
Ig strand C 371..375 CDD:409353 0/3 (0%)
Ig strand E 400..404 CDD:409353 1/3 (33%)
Ig strand F 414..419 CDD:409353 1/4 (25%)
Ig strand G 430..433 CDD:409353 0/2 (0%)
Ig 446..541 CDD:472250 19/100 (19%)
Ig strand B 461..465 CDD:409353 1/3 (33%)
Ig strand C 475..479 CDD:409353 0/3 (0%)
Ig strand E 510..515 CDD:409353 0/4 (0%)
Ig strand F 525..530 CDD:409353 3/4 (75%)
Ig 549..632 CDD:472250 25/90 (28%)
Ig strand B 563..567 CDD:409353 0/3 (0%)
Ig strand C 577..581 CDD:409353 0/3 (0%)
Ig strand E 606..610 CDD:409353 1/3 (33%)
Ig strand F 620..625 CDD:409353 1/4 (25%)
Ig strand G 635..638 CDD:409353 1/2 (50%)
Ig 646..736 CDD:472250 27/104 (26%)
Ig strand B 664..668 CDD:409353 1/3 (33%)
Ig strand C 678..682 CDD:409353 1/9 (11%)
Ig strand E 702..706 CDD:409353 0/3 (0%)
Ig strand F 716..721 CDD:409353 1/4 (25%)
Ig strand G 729..732 CDD:409353 1/2 (50%)
Ig_3 740..820 CDD:464046 25/103 (24%)
IgC1_hNephrin_like 834..942 CDD:143250 29/111 (26%)
putative Ig strand A 839..844 CDD:143250 2/4 (50%)
putative Ig strand B 859..866 CDD:143250 2/6 (33%)
putative Ig strand C 870..876 CDD:143250 1/5 (20%)
putative Ig strand C' 879..881 CDD:143250 0/1 (0%)
putative Ig strand D 888..891 CDD:143250 0/2 (0%)
putative Ig strand E 898..906 CDD:143250 2/7 (29%)
putative Ig strand F 917..924 CDD:143250 2/6 (33%)
putative Ig strand G 939..942 CDD:143250 0/2 (0%)
FN3 941..1022 CDD:238020 24/98 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1025..1057 7/31 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1099..1137 11/54 (20%)
Binds to NPHS2 1160..1241
Blue background indicates that the domain is not in the aligned region.

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