DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and hbs

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	1156	Identity:	236/1156 - (20%)
Similarity:	400/1156 - (34%)	Gaps:	363/1156 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ATTICNFFLIALVALSSTT--------------LADESIDTRENADLTLKCRFNDKYEANDFSFF 72
            |||||:    .:.|:::.|              |....:...|..|..|:|..:::...
  Fly    14 ATTICH----VMAAVTAPTPAAQVAAPPVQKFHLTPHDLQILEGTDTLLRCEVSNRAGK------ 68

  Fly    73 WTRWTANPAQFDNVAIGEVQLSSG---YRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKAKGTG 134
             .:||.     |..|:|...:..|   |.:....::..|:|||||.:. .|:..::|:: ....|
  Fly    69 -VQWTK-----DGFALGFSAVIPGFPRYSVLVDAKQNAYNLQIKNATL-EDDAEYQCQV-GPAAG 125

  Fly   135 ADVHQEFHNLTVLTPPHPPVIS--PGNIAVATEDKP-MELTCSSIGGSPDPTITWYREG----SN 192
            ....:....|:::..|...||.  ..|..|..|::. :.|.|.:...:|...|.|: :|    |.
  Fly   126 NPAIRANAKLSIVAAPSSIVIEGYARNARVEVEERQNLTLHCIAENANPAAEIVWF-QGEVPVST 189

  Fly   193 TPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEV 257
            .|: .||.:...|...|::||.:.||.|||..::.|..|::|:.....:.|...|:|.|.|....
  Fly   190 API-VTVNQTAPKRFTTSSTLHLQPRAEDDYKEFSCEARHKALPPDVPMRAQVQLSVLYPPGAPF 253

  Fly   258 --GPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYTCIA-D 319
              |......:.|.:..::.|..........:.|.|||..|||. ..|..|:| ::..|:|..| |
  Fly   254 FEGYSQGETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAISSP-QRTSGRLS-ENVYKFTAAAED 316

  Fly   320 NGLGKTGE-----------QELILDILYPPMVVIESKTREAEEGDTVTIRCNVTA---------- 363
            ||.....|           .||.|.:||.|..|..|...:|:.||:|.:.| |||
  Fly   317 NGANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGANQAKVGDSVQLSC-VTAPSNPQARISW 380

  Fly   364 ----------------------------------------------------------------- 363

  Fly   381 SINGRPLDNSTYKTTSSSDGGWVSSSNISLTIDSQSRTFIAVCHALNTELTQNVVGSHTVNVLYP 445

  Fly   364 ------------------------------NPAPVTIEWLKE----NSP----DFRYNGDVLTLT 390
                                          ||.| |::|.|.    |:|    |.:...::..|.
  Fly   446 PSPPLLTGYNDGDILISGSILKLQCSSAGGNPPP-TLQWYKNDKIINAPSKLVDSKITSELSLLV 509

  Fly   391 SVRADHAGNYICRAVN---------------------------------------IMQSQGMERS 416
            :. :|:...|.|:..|                                       |..|......
  Fly   510 NA-SDNNAIYKCKVQNAAIDIPLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPP 573

  Fly   417 ERV-----GNSTVALLVRHRPG---------QAYITPNKPVVHVGNGVTLTCSAN---------- 457
            .::     |.....|.:.:|||         :.|:...:.:    :|:..||.::
  Fly   574 AKISWWKDGIPVEGLNLANRPGLWGGSVSTLEMYVNITQDL----DGIVYTCQSHNEVLQRSVHE 634

  Fly   458 --------PPGWPVPQ--------------------------YRWFRD---MDGEFSSTQKILAQ 485
                    ||.:..||                          |.|.:|   :.....|.|::::.
  Fly   635 TISLDILYPPKFETPQSTTFVGVEGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISD 699

  Fly   486 GPQYSIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTRR--VADTDYTVT 548
            ||:.:|.:....:.|.|.|.|:|..|     |.:|||....::...:......|  ||.....:.
  Fly   700 GPRLNISRLSRNDAGVYICEALNSQG-----TALLEIQVAVEYAPTITAVSEGRSFVAGEPAVLA 759

  Fly   549 CSAKGKP--APSVKWLKDAVEILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVP- 610
            |..:.:|  |..|:|.:|.         |::.|.         |:.|   |.     ||.||:.
  Fly   760 CHIQARPLEAAHVRWSRDG---------YDLATR---------TISS---FE-----NGTALLQI 798

  Fly   611 -----GDRGLYTCLYQNEVNS-ANSSMQLRIEHEPIVLHQ--YNKVAFDIRETAEVVCKVQAYPK 667
                 .|.|.:||:..|:..: |..::.|.::..|.:.|.  :.:.|..:...|:::|:..|.|:
  Fly   799 ASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAPEIDHSPGFTRYAARLGVRAQLICRSLASPQ 863

  Fly   668 PEFQWQFGNNPSPLTMSSDGHYE-ISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIRA 731
            |.|.|:  .:...|.|.....:: :....|..: :.|.|.|.:.:..|||:|.|.|.|:|.....
  Fly   864 PSFIWR--RHGKDLKMQRRNKFKSVERQVDALN-FESALLIENTSPDDYGQYECVVRNSLGQAST 925

  Fly   732 PIRLQQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYRRVAMPREEQLIPDCATL 796
            .:...:...|:.|..||...|....|.|:|.||||||:.      :|.|:.:.:
  Fly   926 TLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTPGFDGGMQ------TYFRLRLKQ----------- 973

  Fly   797 ANSNSAWVEVDCQ---RDIPCKVTALEQHQSYAFKVKALNPKSDSPYSSEIMVTTKVSRIPPPLQ 858
             :....:..||.:   ::|  .:..|:...:|.|.|.|.|....|.:..:|.:|......|...:
  Fly   974 -HGEDKYKYVDAKPGHQNI--SLDGLKPGATYYFSVMAANEAGGSKFMPDIKLTLSKGSQPHSAE 1035

  Fly   859 VTYE---PNTRTLGIDVGATCLNLVAVVESMVNADSPMAAWEVVTTMDNLQ 906
            .|.:   ||...:||       ...|:|..::||  .:.||.|:...:..|
  Fly  1036 YTEKDELPNVMIIGI-------TSAAMVLLVLNA--ALVAWFVIRRQNKSQ 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	21/99 (21%)
		I-set	146..249	CDD:254352	30/109 (28%)
		Ig	168..249	CDD:299845	24/85 (28%)
		IGc2	268..323	CDD:197706	17/55 (31%)
		Ig_3	341..406	CDD:290638	23/177 (13%)
		Ig_2	437..514	CDD:290606	21/123 (17%)
		I-set	526..633	CDD:254352	24/117 (21%)
		Ig	546..632	CDD:143165	21/94 (22%)
		IG_like	654..736	CDD:214653	21/82 (26%)
		Ig	656..734	CDD:143165	21/78 (27%)
		FN3	741..848	CDD:238020	27/109 (25%)
hbs	NP_001286439.1	Ig	44..122	CDD:299845	19/91 (21%)
		IG_like	45..137	CDD:214653	21/105 (20%)
		Ig	153..231	CDD:299845	23/79 (29%)
		IG_like	258..342	CDD:214653	22/85 (26%)
		Ig	266..327	CDD:299845	18/62 (29%)
		IG_like	357..>414	CDD:214653	8/57 (14%)
		Ig	360..427	CDD:299845	7/67 (10%)
		Ig	<468..526	CDD:299845	14/59 (24%)
		I-set	547..633	CDD:254352	11/89 (12%)
		Ig	556..631	CDD:299845	11/78 (14%)
		I-set	644..735	CDD:254352	21/95 (22%)
		IGc2	668..725	CDD:197706	13/56 (23%)
		IG_like	751..829	CDD:214653	24/103 (23%)
		IGc2	753..815	CDD:197706	19/87 (22%)
		Ig	852..928	CDD:143165	21/78 (27%)
		FN3	935..1017	CDD:238020	26/101 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451331
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840