Protein Alignment ed and LOC4397681

DIOPT Version :10

• Sequence 1: NP_523469.2
• Gene: ed / 33619
• FlyBaseID: FBgn0000547
• Length: 1332
• Species: Drosophila melanogaster
• Sequence 2: XP_061513195.1
• Gene: LOC4397681 / 4397681
• VectorBaseID: AGAMI1_007390
• Length: 1403
• Species: Anopheles gambiae
• Alignment Length: 1562
• Identity: 303/1562 - (19%)
• Similarity: 487/1562 - (31%)
• Gaps: 547/1562 - (35%)

  Fly    10 TAIVNSRSARRAAT--TICNFFLIALVALSSTTLADESIDTRENADLTLKCRFNDKYEANDFSFF 72
            |.::..:..|...|  |:...||..:.......|....:...|.|:..|:|..::...    |..
Mosquito     2 TKMIQQKLPRAVLTILTVVPLFLPCIAEQQKFRLIPGDLVVSEGAEALLRCEIHNAAG----SVQ 62

  Fly    73 WTRWTANPAQFDNVAIGEVQLSSGYRLDFQPE--------RGIYDLQIKNVSYNRDNGRFECRIK 129
            ||:        |..|:|..|...||     |.        :|||:|:|.||:. .|:..::|::
Mosquito    63 WTK--------DGFALGFTQSIPGY-----PRYSVLGDSGQGIYNLRIVNVTL-EDDAEYQCQV- 112

  Fly   130 AKGTGADVHQEF----HNLTVLTPP----------HPPVISPGNIAVATEDKPMELTCSSIGGSP 180
                |..:|.:.    ..|||:.||          |..|       ...|.:.:.|||......|
Mosquito   113 ----GPYMHHKLIRAKARLTVIAPPTSIQIQGYSQHAKV-------EVREGEELTLTCVVPNARP 166

  Fly   181 DPTITWYREG----SNTPLPATVLKGGTKDQPTNAT--LSIIPRREDDGAKYKCVVRNRAMNEGK 239
            ...|.|||..    |||   .......|:|....||  |.:.|..|||...|.|..|::|:.|.:
Mosquito   167 AAQIVWYRANVEYKSNT---IETKSAETEDHRYTATSKLQLQPTAEDDYIDYTCQARHQAIPEDR 228

  Fly   240 RLEATATLNVNYYPRVE----VGPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNG-------- 292
            .:::|..|:|.|.|.|.    ..|...:|  |.:..:|.|..........:.|.:||
Mosquito   229 PMQSTVQLSVLYPPGVPYIEGYAPGEVIR--RGQHVQLACRSRGGNPPAQLIWYKNGNQARMAYR 291

  Fly   293 ---RFISSSLVHTIHRVSVQDAGKYTCIADNGLG-KTGEQELILDILYPPMVVIESKTREAEEGD 353
               ||  |..::.....:..:..:..|.|:|.:. |..:.|:||::|:.|..||.|...||..||
Mosquito   292 TTDRF--SENIYAFVAEASDNKARLRCEANNKMATKILKAEIILNVLFAPTQVIVSGPSEARVGD 354

  Fly   354 TVTIRCNVTANPAPVTIEWLKEN------------SPDFRYNGDVLTLTSVRADHAGN-----YI 401
            :|.::|..||:.....|:|:...            ||:    |..:|.:::.|....:     .|
Mosquito   355 SVALQCQTTASNPAAEIKWVVNGKQVTNASSKVVPSPE----GGWVTTSNITATVEASKRSLVAI 415

  Fly   402 CRAVNIMQSQGMERSERV---------------------------------GNSTVALLVRHRPG 433
            |..||:...:.::.:..|                                 |.:.:|.||.::..
Mosquito   416 CHGVNMQLPENVQSTHTVNVLLPPGPPIISGYTEGSIITVGTRQKIMCTSSGGNPLATLVWYKND 480

  Fly   434 Q--------------------AYITPNKP---------------------VVHV----------- 446
            :                    |.:|.|:.                     .||.
Mosquito   481 KKIKSVSKTTDQSVSAELSMLANVTDNQAQYRCEAHNSATEIPLFETKVLTVHFAPETAKIRIEP 545

  Fly   447 -----GNGVTLTC---SANPPGWPVPQYRW--------------------------------FRD 471
                 |...||.|   |:|||.    :..|                                .:|
Mosquito   546 AELRPGIEATLICDSSSSNPPA----KLSWRHEGTVLEGTNNSSKAGLWGGTVSSLELKLNITQD 606

  Fly   472 MDGEFSSTQ-------------------------------------------------------- 480
            |||...:.|
Mosquito   607 MDGHVYTCQSTNEMLQRSINVAVNLPVLYEPRFQTPAETVVHGVAGEPLTVALVATGNPSSIAYT 671

  Fly   481 -----------------KILAQGPQYSIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQF 528
                             :|:::||..:|.|....:.|.|.|.|||..|..|: .|.|::......
Mosquito   672 WTKNGQTIASTGSSGEPRIVSEGPILNITKLERTDAGVYTCEAVNSQGSAMI-NITLQVKYAATI 735

  Fly   529 LAKLQQHMTRRVADTDYTVTCSAKGKP-APS-VKWLKDAVEILPEENLYEVQTNPDQGLNGMVTV 591
            .| :.:|:|....: |..:.|:..|.| .|. ::|.:|..::..     :..|....|...:|..
Mosquito   736 KA-ISEHVTVDPGE-DAILNCTVDGNPLTPDHIRWERDGYDLRA-----KTTTGYANGTGTLVVK 793

  Fly   592 QSQLKFRGKARPNGNALVPGDRGLYTCLYQNEVNSANSSMQL-------RIEHEPIVLHQYNKVA 649
            .:|.:               |.|.:.|:..|.|.:..|...|       .|:..|.:|    :.|
Mosquito   794 DAQRE---------------DVGNFRCIADNRVAAPESRNVLLIVKFAPEIDKSPAML----RAA 839

  Fly   650 FDIRETAEVVCKVQAYPKPEFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSD 714
            ....:.|.:.|:.:|.|.|.|.|.......|:..||. :|.:....|.. .:.|:|.|..::..|
Mosquito   840 SGPGDQARLPCRAKAAPAPIFHWIRTGQELPINQSSK-YYTLQRQLDPL-THESILVIERISSRD 902

  Fly   715 YGEYTCRVANTLDTIRAPIRLQQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYR 779
            ||:|.||..|.|.:.....||..:..|:.|..|....|.|:.|:|.|:|||||| .:..:.:.||
Mosquito   903 YGDYECRAKNELGSGSGTGRLDVRSAPDSPATLTVLNVTHDSVTLGWEPGFDGG-HRASYRIRYR 966

  Fly   780 RVAMP--REEQLIPDCATLANSNSAWVEVDCQRDIPCKVTALEQHQSYAFKVKALNPKSDSPYSS 842
            .....  |.|...|:...|.                  |..|..:..|.|.:.|.|...:|.|..
Mosquito   967 EATSERYRYEDGPPNAHQLT------------------VAGLRSNTLYLFSIMAANVLGESRYLP 1013

  Fly   843 EI-MVTTKVSRIPPPLQVT--------YEPNT-RTLGIDVGA----TCLNLVAV----------- 882
            :: ...||..:..||::.:        ..|:| ..|||.|.|    ..||::.:
Mosquito  1014 DLTRAQTKERQPQPPMESSSFLAPSSPAGPSTLMLLGIGVAAGIALVLLNILLIGFCLYRRSLPG 1078

  Fly   883 ----------------------------VESMVNADSPMAAWEVVT---------TMDNLQLSGN 910
                                        ..:.:...:|.:..:.||         ..|.....|:
Mosquito  1079 SSSSRRARHDHKYTGALYNSGDSSNPNSKSATIEMYAPSSYNDTVTGETLSSVSEKSDAYSNDGS 1143

  Fly   911 GPTHKEKIIDRIIGARRVGGGRA----------LGHTISEDEDDNGLNSLALEDENSPTVRVKLC 965
            .|...::...|.:....:.||..          |.|..|....:||.      |::.||.::|
Mosquito  1144 QPDFMDETRKRAVSTYLIDGGEMQPPRYQQEGNLPHYASNTGTENGY------DQSGPTDQLK-- 1200

  Fly   966 LRTNPEHCGDYTDAEIGRPYIAEANALATPTLIAIIVSCVVFALFAGLILMFCRCKRNQSKKSAA 1030
               |....|.|
Mosquito  1201 ---NSTMDGSY------------------------------------------------------ 1208

  Fly  1031 AKDYEMDSVR---PSIVAAQQNQAPP-PYYPASGLDNKALEHSMDLALSMEDQKTALYAT--QNG 1089
               |.|::.|   |......:...|| |..|:.|....:.|....:|.:|.......:.|  :.|
Mosquito  1209 ---YHMNNDRFYPPMDYPGVEFPTPPLPILPSVGPTESSSETLRRVARTMVPPPDVTHHTHHRTG 1270

  Fly  1090 YSYHPGSGVVGVGMGGGVVGVGVGGSVVSGMGGGVGGIGGSGVGVNGIPGLSAHTMPGNEWVNMG 1154
            ...|..|. :...:..|.:...:..:|                       .|....|      .|
Mosquito  1271 GQQHDSSS-LSTTLPFGSLNASISQAV-----------------------QSTPKQP------QG 1305

  Fly  1155 YMEN-NYSNSNNGGSVNSQDSLWQVKMSAAAVGNQQGMVQAPMNQYVEQQPAYG--YDPLTHGGY 1216
            .::: ..|||:..||........|.:....::.|...:   |.:|||.....||  .||..|.|.
Mosquito  1306 ILKDPKRSNSSASGSHTYSSLPLQQQQQLYSIHNPSPI---PSDQYVAGPSGYGLMMDPQGHVGT 1367

  Fly  1217 GA 1218
            .|
Mosquito  1368 SA 1369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_523469.2	V-set	50..147	CDD:462230	27/108 (25%)
		Ig	153..249	CDD:472250	29/101 (29%)
		Ig strand B	169..173	CDD:409353	1/3 (33%)
		Ig strand C	183..187	CDD:409353	1/3 (33%)
		Ig strand E	211..215	CDD:409353	3/5 (60%)
		Ig strand F	225..230	CDD:409353	2/4 (50%)
		Ig strand G	242..245	CDD:409353	0/2 (0%)
		Ig_3	253..320	CDD:464046	15/81 (19%)
		Ig_3	337..406	CDD:464046	21/85 (25%)
		Ig_2	437..>504	CDD:464026	25/211 (12%)
		Ig	525..635	CDD:472250	21/118 (18%)
		Ig strand B	545..549	CDD:409568	0/3 (0%)
		Ig strand C	558..562	CDD:409568	0/4 (0%)
		Ig strand E	587..591	CDD:409568	1/3 (33%)
		Ig strand F	615..620	CDD:409568	1/4 (25%)
		Ig strand G	628..631	CDD:409568	1/2 (50%)
		Ig_3	639..724	CDD:464046	24/84 (29%)
		FN3	741..848	CDD:238020	28/109 (26%)
LOC4397681	XP_061513195.1	None