DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and side-VI

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_001036705.1	Gene:	side-VI / 4379854	FlyBaseID:	FBgn0083950	Length:	1087	Species:	Drosophila melanogaster

Alignment Length:	1178	Identity:	245/1178 - (20%)
Similarity:	404/1178 - (34%)	Gaps:	312/1178 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 LRVERDRTAKLECNV---DAKPKVPNVRWNRNG----------------------RFISSSLVHT 302
            |||..:.:|:::|:|   .|..||..|.|.:|.                      ..:....|..
  Fly    35 LRVLVNSSAQIKCDVGSSQADDKVLLVVWYKNNLPIYSYDTRGAHAGTPSHWRDEEVLEDRAVFR 99

  Fly   303 IHR---------VSVQDAGKYTCIADNGLGKTGEQELILDILYPP---------MVVIESKTREA 349
            .|:         |..:|||.:.|..|..|.:|....:.|:::.||         .:.|:|:....
  Fly   100 THKEPAELIINPVKEKDAGNFRCRVDFKLSQTRNSNVNLEVVVPPTQPIIFNERRLRIDSRAGPY 164

  Fly   350 EEGDTVTIRCNVTANPAPVTIEWLK----ENS-PDFRYNGDVLTLTSVR-----ADHAGNYICRA 404
            |||.::.:.|.|.....|.|:.||.    :|| .|:.|:|.:.:...||     ..|| .|.|:|
  Fly   165 EEGGSLEVTCVVYGGSPPPTVIWLMNGQLQNSVVDYTYDGAINSKLVVRNLSRIHQHA-VYTCQA 228

  Fly   405 VNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTCSA---NPPG---WPV 463
            .|      ..:.....|.|:.|.:  ||....|:.|...:.......:.|.|   .||.   |
  Fly   229 SN------FHKKYVATNITIDLYL--RPLLVEISFNNQPMSADRKYEIECQAIGSRPPAKITW-- 283

  Fly   464 PQYRWFRDM-----------DGEFSSTQKILAQGPQYSIPKAHLGNEGK-YHCHAVNEL---GIG 513
                |..::           ||..|::  :|:..|...       :.|| ..|.|.|||   ||.
  Fly   284 ----WMGNLELHGHSQKVSEDGNVSTS--VLSITPTRE-------DHGKALSCRATNELVRNGIR 335

  Fly   514 MMATIVLEIHQPPQFLAKLQQHMTRRVAD--TDYTVTCSAKGKPAPSVKWLKDAVEILPEENLYE 576
            ..| :.|.:...|.....|..::.....:  .|....|.....||        |.:::.:.|...
  Fly   336 ETA-MKLNVFFIPTLQLDLGSNLNPEDIEEGDDVYFECKVHANPA--------AYKVVWKHNHQI 391

  Fly   577 VQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRGLYTCLYQNEVNSANSS-MQLRIEHEPI 640
            :|.|...   |::.....|..:|..|...        |.|||...|.....:|: ::|::.::||
  Fly   392 IQHNQRA---GVIVSSGDLALQGVTRHQA--------GNYTCTASNVEGDGDSNVVELKVMYKPI 445

  Fly   641 VLHQYNKVAFDIR-ETAEVVCKVQAYPKPE-FQWQFGNNPSPLTMSSDG----HYEISTTTDNND 699
            ......|:....| |.||:||:|.|:|.|| |:|.|.|......|...|    ..:.||.|
  Fly   446 CRPDQKKIYGVARNEAAEIVCEVDAFPPPENFKWSFNNTAETFDMPQSGFRPHSAQGSTLT---- 506

  Fly   700 IYTSVLKINSLTHSDYGEYTCRVANTLDTIRAP--IRLQQKGPPEKPTNLRATEVGHNYVSLSWD 762
             ||.|.::      |:|...|...|.:...:.|  ..|...|.||.|||........:.:.:...
  Fly   507 -YTPVKEM------DFGTIMCWADNNVGQQKEPCVFHLIAAGKPEAPTNCTVVNQTSDSLEVYCI 564

  Fly   763 PGFDGGLSKTKFFVSYRRVAMPREEQLIPDCATLANSNSAWVEVDCQRDIPCKVTALEQHQSYAF 827
            .|||||:.:......:.:.:...:..:....|.|:                  ||.|:..:.:..
  Fly   565 EGFDGGMRQWFLMEIFDQHSGQLQANISAKFAALS------------------VTGLDAGRLFRI 611

  Fly   828 KVKALNPKSDSPYSSEIMVTTKVSRIPPPLQVTYEPNTR-----------TLGIDVGATCLNLVA 881
            .|.|:|.:..|...:....|.|.:........:|:.:.:           ::||.||.    |||
  Fly   612 YVYAVNGRGRSDAIALDGYTLKAAEKQTVALTSYKGSAQSPDNFELTPILSIGIFVGI----LVA 672

  Fly   882 VVESMVNADSPMAAWEVVTTMDNLQLSGNGPTHKEKIIDRIIGARRVGGGR---ALGHTISEDED 943
            :|...:.            |:..|:|..:....::|.:.......|.|..:   .:...:|..|:
  Fly   673 IVCIGIG------------TIAALKLRSHKHQQQQKFVHPNAKFSRPGNLQIKDKISLPLSHSEE 725

  Fly   944 DNGLNSLALEDENSPTV----------RVKLCLRTNPEHCGDYTDAEIG-RP------YIAEANA 991
                    :.||.:|.|          :.|...:|...|....::.||. :|      .|.:||:
  Fly   726 --------MYDEKNPDVVPYNEVDGEYKQKSATQTPSGHLSTTSEVEISCKPGSTSGTGIVQANS 782

  Fly   992 LATPTLIAIIVSCVVFALFA---------------------GLILMFCRCKRNQSKKSAAAKDYE 1035
            ..:.|..:.....:.:|..:                     |::....: ::.|.::......::
  Fly   783 ADSGTYQSSKDDELHYAELSLTNMPSGSSGASKKGQPMGGVGVVQHVVQ-QQQQQQQGQVQHPHQ 846

  Fly  1036 M--------DSVR------PSIVAAQQNQ------------APPPYYPASGLDNKALEHSMDLAL 1074
            :        .|:|      |:....|:::            ||||.|     |....|
  Fly   847 LLGGTLPHGSSMRKLLPTIPATATLQRHKPNAGGMQHPHQHAPPPTY-----DYDYFE------- 899

  Fly  1075 SMEDQKTALYATQNGY-SYHPGSGVVGVGMGGGVVGVGVGGSVVSGMGGGVGGIGGSGVGVNGIP 1138
                 :..:||..:.| :....:|||..|:|.|      .||.|:|.|..:...|..|......|
  Fly   900 -----EPTIYAQIDAYKTMQVDTGVVVAGVGAG------AGSGVNGAGASISSPGSHGTPSTVSP 953

  Fly  1139 GL-----------SAHTMPGNEWVNMGYMENNYSNSNNGGSVNSQDSLWQVKMSAAAVGNQQGMV 1192
            |.           ..||:|.|..... .|.....||.:...:..|....|.:|......|.....
  Fly   954 GTVQMYTLPQHPGGYHTLPHNHHAQQ-QMAGGPQNSASMMQMMQQQQQQQQQMHHHPASNMPPSY 1017

  Fly  1193 QAPMNQYVEQQPAYGYDPLTHGGYGAVDDYAPYPHLTATPSQ-------VGDEYH----NLRNSQ 1246
            |....|..:||.|:|...::....|.....|    ..|:||.       ||..|.    .:|...
  Fly  1018 QQHQQQQQQQQMAHGQMLVSSNSSGLASTTA----AVASPSSSLSGLSGVGKSYSREIVTVRTPL 1078

  Fly  1247 NPSRQDYC 1254
            ..|:|:.|
  Fly  1079 MYSQQESC 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845
		I-set	146..249	CDD:254352
		Ig	168..249	CDD:299845
		IGc2	268..323	CDD:197706	17/88 (19%)
		Ig_3	341..406	CDD:290638	23/74 (31%)
		Ig_2	437..514	CDD:290606	22/97 (23%)
		I-set	526..633	CDD:254352	20/109 (18%)
		Ig	546..632	CDD:143165	17/86 (20%)
		IG_like	654..736	CDD:214653	27/88 (31%)
		Ig	656..734	CDD:143165	26/84 (31%)
		FN3	741..848	CDD:238020	19/106 (18%)
side-VI	NP_001036705.1	IG_like	35..140	CDD:214653	23/104 (22%)
		Ig_3	157..230	CDD:290638	23/73 (32%)
		IG_like	165..242	CDD:214653	23/83 (28%)
		Ig	265..343	CDD:299845	22/93 (24%)
		IG_like	267..343	CDD:214653	22/91 (24%)
		IG_like	363..440	CDD:214653	19/95 (20%)
		IGc2	364..429	CDD:197706	17/83 (20%)
		IG_like	456..532	CDD:214653	27/86 (31%)
		Ig_3	456..524	CDD:290638	26/78 (33%)
		fn3	545..622	CDD:278470	16/94 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810