Protein Alignment ed and side-III

DIOPT Version :10

• Sequence 1: NP_523469.2
• Gene: ed / 33619
• FlyBaseID: FBgn0000547
• Length: 1332
• Species: Drosophila melanogaster
• Sequence 2: NP_001036681.1
• Gene: side-III / 4379844
• FlyBaseID: FBgn0083949
• Length: 1689
• Species: Drosophila melanogaster
• Alignment Length: 1733
• Identity: 313/1733 - (18%)
• Similarity: 533/1733 - (30%)
• Gaps: 614/1733 - (35%)

  Fly     2 RRKTTTKGTAIVNSRSARRAATTICNFFLIALVALSS------------TTLADESIDTRENADL 54
            :|.:|...|...|:...|........|...|.::|:|            :|:|.|::..|   ..
  Fly     6 KRTSTMPLTTSYNANIRRSCLALFALFLFAAHISLTSGQIDWDDDDDPVSTVAVEAVLGR---TA 67

  Fly    55 TLKCRFNDKYEANDFSFFWTRWTANPA------------QFDNVAIGEVQLSSGYRLDF----QP 103
            :|.|....  ||.|...:...|....|            .|:.........|.|.|..|    ||
  Fly    68 SLPCDIEP--EAKDDRVYMVLWFRESAGKPLYSFDVRGRPFEKALYWSDTNSFGPRAYFVTGQQP 130

  Fly   104 ERGIYDLQIKNVSYNRDNGRFECRIKAKGTGADVHQEFHNLTVLTPPHPPVI-------SPGNIA 161
            .:    |.:.|:..: |.|.:.||:..:.:....|:  .||||:.|||..::       ..|.:.
  Fly   131 AK----LSVDNIQLD-DEGVYRCRVDFQNSPTRNHR--INLTVIVPPHQILVYDASGRDVAGAVG 188

  Fly   162 VATEDKPMELTCSSIGGSPDPTITW-------------------------------------YR- 188
            ...|...:.|||...||.|:||:||                                     ||
  Fly   189 PLLEGDNIVLTCEVRGGRPEPTVTWMNGTRTLEAGSGVSMGRHVTVNRLEVAQISRSALNNTYRC 253

  Fly   189 EGSNTPL--------------------------------------------PATVLKGGTKDQPT 209
            :.|||.|                                            |.|.:|....::|.
  Fly   254 QASNTKLVAPVERSIRIEMLLKPTSVNLTNKLKVFASNTQYNLTCIVAGSVPDTEIKWTQNNRPF 318

  Fly   210 N--------------ATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEVGPE 260
            .              :||:..|:.||||...||...|..: :...:|.:..:||.|.|:|.:...
  Fly   319 KRGLLSTSQSNGRVISTLTFYPQPEDDGTMLKCEGSNPRL-QNSAIEDSLMMNVIYPPQVTLSLG 382

  Fly   261 NPLR---VERDRTAKLECNVDAKPKVPNVRWNRNGRFISSS-----LVHT----IHRVSVQDAGK 313
            :.||   ::.......||::.:.||...:.|:.:|:.::.:     ::.|    :.||....:|.
  Fly   383 STLRPDDIKEGDDVYFECHIKSNPKEHRIMWSHDGQPVTQNVSWGIIISTRSLVLQRVGRIHSGF 447

  Fly   314 YTCIADNGLGKTGEQELILDILYPPMVVIESKT---REAEEGDTVTIRCNVTANPAPVTIEWLKE 375
            |.|.|.|..|:|....:.|.|.|.|:....|.|   ...||  .|.|.|.|.::|..:..||
  Fly   448 YACSAANDRGETQSAPVNLRIRYAPVCSSSSITVIGASLEE--DVPIPCRVNSDPPEIDFEW--- 507

  Fly   376 NSPDFRYNGDVLTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPN 440
               .|..:|:...:.|      |:|.     .:|...|..:..|..:.|.....|  .::|:...
  Fly   508 ---TFSTSGEHFEVPS------GHYA-----TIQDPTMTTTSDVRRTVVESNETH--FESYVETV 556

  Fly   441 KPVVHVGNGV----TLTCSANPPGWPVPQYRWFRDMDGEFSST---QKILAQGP---------QY 489
            ..:::...|.    ||.|             :.|:..|:.|..   |.:.|..|         .|
  Fly   557 SELIYTPKGERDYGTLAC-------------YGRNAIGKQSDPCVFQVVPAAKPGALRNCTLRPY 608

  Fly   490 SIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQF--LAKLQQHM---------------- 536
            .:..|.|.:..:...|| |::             .|.|:  ......||
  Fly   609 VVTSASLNSSNQTTMHA-NQI-------------LPTQYGRHESNYPHMEYVRERHNSSGGNNNG 659

  Fly   537 TRRVADTDYTVTCSAKGKPA-------------PSVKWLKDAVEILPEENLYEVQ--------TN 580
            |...|..:.....:.:|:.:             ..::.||......|.:.|..::        :.
  Fly   660 TAPAAGRNNVANKNMRGRTSAGQAKSNNKQLTQQQLQRLKKRTSFTPSQTLAAIERQRQRKQLSQ 724

  Fly   581 PDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRGLYTCLYQNEVNSANSSMQLRIEHEPIVLHQY 645
            ..|.|.......:..|..|..:|:|:......:.:.......::.......|.: :|:   ||..
  Fly   725 QQQQLQQQHHQATATKSGGDNKPDGSPAKSSKQRMRRASRDPQIQQQQQHQQQQ-QHQ---LHAA 785

  Fly   646 NKVAFDIRETAEVVCKVQAYPK-------------PEFQWQFGNNPSPL--------TMSSDGHY 689
            ..:....|:.||.........|             .....:..|...|.        .|....|.
  Fly   786 TSITSSQRKQAESNLSTSHLGKGSSSSSRSRRSSSSNINSKSNNGKQPAKYFNKRQKNMHKQKHQ 850

  Fly   690 E-----ISTTTDNND--------IYTSVLKINSLTHSDYGEYTCRVANTLDTIRAPIRLQQKGPP 741
            :     ..||.::|.        :.:|:.:...|..:|. ..|...|:|..::.:|       |.
  Fly   851 QKLKQLKGTTNEHNSNIIHHYAALSSSLRRRKRLAANDI-LATVAAASTSASLSSP-------PA 907

  Fly   742 EKPTNLRAT-----EVGHNYVSLSWDPGFDGG----LSKTKFFVSYRRVAMPREEQLI-PDCATL 796
            ....:|.||     |:..: ||....|..|.|    .|:....:..::.....::||: |:...:
  Fly   908 SSAASLAATATAAVEIEQD-VSAVDAPAADSGSNNKRSRKSLTILDKQKQQQEQQQLLPPNAPQI 971

  Fly   797 ANSNSAWVEVDCQRDIPCKVTALEQHQSYAFKVKALNPKS-------------------DSPYSS 842
            :|...|.:..:..::    ..|...|.:.|..||...|.|                   |....:
  Fly   972 SNQPVAAISGNNVKE----TAATSAHGAVAAGVKDKAPSSKEDSTDNDNDSDGDEDDDDDDDDGA 1032

  Fly   843 EIMVTTK------------------------VSRI----------PPPLQVTYEPNTRTLGIDVG 873
            ||...|:                        |:::          |..|| .||....   :|..
  Fly  1033 EIDAETETNDEEEDEDEGGEAHDDDADLDEDVAQLATDADYLADGPGDLQ-EYETVEE---VDGQ 1093

  Fly   874 ATCLNLVAV--------------------VESMVN-ADSPMAAWEVVTTMDN-----LQLSGNGP 912
            |..::::::                    |:.|.| :|....|...::|.|.     ||.:..||
  Fly  1094 AKHVHMLSLEEQLDLESLEDNVEEEDDGEVDDMYNVSDDDFVASVALSTSDTTAATPLQRTTEGP 1158

  Fly   913 THKEK--------------------------------IIDRIIGARRVGG----GRALGHTISED 941
            ..:||                                :...::|...|.|    |.|.|.||:.|
  Fly  1159 HIREKATQSQTQTDSATEWQLPHFDYSRMEYSFSNGVVTQSLLGGGAVTGAGHDGFAGGGTINFD 1223

  Fly   942 EDDN----------------GL-NSLALEDENSPTVRVKLCLRTNPEHCGDYTDAEIGRPYIAEA 989
            ..||                || ....||..:|.|::::|.:.:.      |.|..:.|..:::.
  Fly  1224 NYDNIIYSTMELECMPGYDGGLQQQFFLEAYDSKTMKLRLNMSST------YMDVPVFRIDLSDL 1282

  Fly   990 NAL-----ATPTLIAIIVSC--------VVF------------------------ALFAG----- 1012
            ..:     |.|.|..::.|.        :|.                        ||.||
  Fly  1283 MPMDYYPDAHPALHLVVYSVNQKGRSEPIVLENVPINEADKRSDGRMGLSILPLAALLAGTLFTV 1347

  Fly  1013 ------LILMFCRCKRNQSKKSAA---AKDYEMD--------------------------SVRPS 1042
                  ::::..|.:|.|..::..   .|...||                          ..:|.
  Fly  1348 GIAVLSVVVIAVRRRRGQGARNMCDDKDKHLGMDVTVTAPLETGAGHQRLVVAYTLKQGIEKQPD 1412

  Fly  1043 IVAAQQNQAPPPYYPASGLDNKALEHSMDLALSMEDQKTALYATQNGYSYHPGSGVVGVGMGGGV 1107
            |::||::.      |..|          |.:..:.::.:.|:|...|          |.|.|||.
  Fly  1413 ILSAQKSA------PTGG----------DASSPLGNRPSGLFAGGGG----------GGGGGGGA 1451

  Fly  1108 VGVGVGGSVVSGMGG-------------------------------GVGGIGGSGVGVNGIPGLS 1141
            .|:.....:....||                               |.||:.|:..|.:. |.|.
  Fly  1452 AGLASAAPMTGNTGGHKTTDYDGNAPHLNSPPSQSSTLKLESDPAAGGGGLVGARSGGSN-PPLL 1515

  Fly  1142 AHTMPG-NEWVNMGYMENNYS-NSNNGGSVNSQDSLWQVKMSAAAVGNQQGM--VQAPMNQYV-- 1200
            ...||. :.:..:|....:|| .:..|||.::..|......:|.|.....|.  ..|.::..:
  Fly  1516 YDAMPTLSRYEQLGLSMASYSAGAGTGGSSSTLSSAGSTVSNAMAANGSAGPGGYAAHLHHTLPH 1580

  Fly  1201 EQQPAYGYDPLTHGGY---GAVDDYA----PYPHLTATPSQVG 1236
            ...|..|:|||....|   .::.||.    |..|:| .|..:|
  Fly  1581 NMAPQRGHDPLNLADYLTTSSLIDYGLNKPPAAHMT-LPKGMG 1622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_523469.2	V-set	50..147	CDD:462230	24/112 (21%)
		Ig	153..249	CDD:472250	33/198 (17%)
		Ig strand B	169..173	CDD:409353	1/3 (33%)
		Ig strand C	183..187	CDD:409353	3/40 (8%)
		Ig strand E	211..215	CDD:409353	2/3 (67%)
		Ig strand F	225..230	CDD:409353	2/4 (50%)
		Ig strand G	242..245	CDD:409353	1/2 (50%)
		Ig_3	253..320	CDD:464046	17/78 (22%)
		Ig_3	337..406	CDD:464046	17/71 (24%)
		Ig_2	437..>504	CDD:464026	13/82 (16%)
		Ig	525..635	CDD:472250	18/148 (12%)
		Ig strand B	545..549	CDD:409568	0/3 (0%)
		Ig strand C	558..562	CDD:409568	0/3 (0%)
		Ig strand E	587..591	CDD:409568	0/3 (0%)
		Ig strand F	615..620	CDD:409568	0/4 (0%)
		Ig strand G	628..631	CDD:409568	0/2 (0%)
		Ig_3	639..724	CDD:464046	17/118 (14%)
		FN3	741..848	CDD:238020	25/135 (19%)
side-III	NP_001036681.1	V-set	59..166	CDD:462230	25/118 (21%)
		Ig_3	190..257	CDD:464046	13/66 (20%)
		Ig	289..359	CDD:472250	14/70 (20%)
		Ig strand C	308..312	CDD:409468	1/3 (33%)
		Ig strand E	335..338	CDD:409468	2/2 (100%)
		Ig strand F	348..353	CDD:409468	2/4 (50%)
		Ig_3	374..454	CDD:464046	17/79 (22%)