DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and side

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_001247334.1	Gene:	side / 43300	FlyBaseID:	FBgn0016061	Length:	986	Species:	Drosophila melanogaster

Alignment Length:	755	Identity:	165/755 - (21%)
Similarity:	278/755 - (36%)	Gaps:	161/755 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 RFECRIKAKGTGA--DVHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTCSSIGGSPDPTIT 185
            |.|||  |:||..  .|.::......|.|....:.:|..:  .|..:||.:.|.|.|..|...||
  Fly   295 RIECR--AQGTRLVDPVRKDVTVQVYLKPVRVKIATPNEL--LTAGQPMPIRCESWGSYPAAKIT 355

  Fly   186 WYREGSNTPLPATVLKGGTKDQPTNATLSIIPRR---EDDGAKYKCVVRNRAMN---EGKRLEAT 244
            |..:|.  |:....:...:..:..|.|.||:..:   |:|.|:..|    ||.|   .|..:|..
  Fly   356 WLLDGE--PIRNAEVTVHSDKEDGNITTSILTLKVTSENDNAELTC----RATNPWFSGGAIEDK 414

  Fly   245 ATLNVNYYPRVEV--GPENPLRV---ERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIH 304
            ..:.|.|.|.|.|  ..|:|.|:   ...:....:|..||:|.|.:..|.:||..:|......:|
  Fly   415 RIIRVAYPPTVSVHLANEDPSRLVTRAEGQNVTFKCRADARPPVTSYSWFKNGMRMSGESTEIMH 479

  Fly   305 --RVSVQDAGKYTCIADNGLGKTGEQELILDILYPPMVVIESKTREAEEG----DTVTIRCNVTA 363
              ::..:.||.|.|.|.|..|:|....|.|.:.:.|.  .:|.|.:...|    .::.::|.|.|
  Fly   480 LTQLERESAGAYACGATNTEGETRSSSLTLKVQFSPR--CKSGTEQTSIGAVSLHSILVKCEVDA 542

  Fly   364 NPA-PVTIEWLKENSPD--------FRYNGDVLTLTSVRADHAGNYICRAVNIMQSQGMERSERV 419
            :|. .|...|...|:.:        .:.||...|:|         |:.:..:.:.:.....|..|
  Fly   543 DPPDSVRFSWTYNNTRNVSPVLNSRIQSNGLASTVT---------YLPQTDSELITLACWASNAV 598

  Fly   420 GNSTVALLVRHRPGQAYITPNKP-VVHVGNGVTL--TCSANPPGWPVPQYRWFRDMDGEFSSTQK 481
            |..|...||...|..   ||..| ...:.|...|  .|.|...| .:.||.....:.|:
  Fly   599 GRQTTPCLVHILPAN---TPEAPKACELRNDTVLEVVCVAGSDG-GLSQYFMLEVVGGD------ 653

  Fly   482 ILAQGPQYSIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTR-RVADTD- 544
                 |.||........:|:........||...::|:..:....|.|  ::|::..: |:.:.:
  Fly   654 -----PLYSGDPGGSAGQGRGQFSEAIGLGDNEISTLNDQATSAPIF--RMQENSPQFRLNNLEP 711

  Fly   545 --------YTVTCSAKGKPAPSVKWLKDAVEILP-EENLYEVQTNPDQGLNGMVTVQSQLKFRGK 600
                    |.|....:.:|...::.::.|.::.| :|::......|           ::....|.
  Fly   712 GREYQFLVYAVNAKGRSEPPVVIENVRVAAQLGPYDESILSEDPTP-----------AETTHHGG 765

  Fly   601 ARPNGNALVPGDRGLYTCLYQNEVNSANSSMQLRIEHEPIVLHQYNKVAFDIRETAEVVCKVQAY 665
            ....|:.   ...||.|...........|::.:.   ..:|:.....|...|.....|||:.:
  Fly   766 GGVGGSG---SSSGLGTGASTGSGPEKQSTLLIL---AAVVVIGAVVVTSIIVAGIVVVCRHR-- 822

  Fly   666 PKPEFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIR 730
            |:|         |.|..:..      |.....||:.:..::.:.|...:.|  ..|.|:    ||
  Fly   823 PRP---------PEPQEVRK------SMRPARNDVPSMYIEEDELNELEEG--GGRAAD----IR 866

  Fly   731 APIRLQQKGPPEK----------PTNLRATE---VG----HNYVSLSW----DPGFDGGL----- 769
            |.:     .||..          |..:.::.   ||    |:|:|.|:    .|..:|.:
  Fly   867 ARV-----APPNSHLCGGGGMPMPGGVGSSGGAIVGVAGPHHYISESFIQYAQPSLNGDVLLPLL 926

  Fly   770 ------SKTKFFVSYRRVAMPREEQLIPDCATLANSNSAW 803
                  ..|...:|...:||| :.:|.||   .|:.|:||
  Fly   927 VTSSQPCSTNSTISSVVLAMP-QAKLCPD---PASRNTAW 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	8/25 (32%)
		I-set	146..249	CDD:254352	28/108 (26%)
		Ig	168..249	CDD:299845	24/86 (28%)
		IGc2	268..323	CDD:197706	16/56 (29%)
		Ig_3	341..406	CDD:290638	15/77 (19%)
		Ig_2	437..514	CDD:290606	17/79 (22%)
		I-set	526..633	CDD:254352	17/117 (15%)
		Ig	546..632	CDD:143165	12/86 (14%)
		IG_like	654..736	CDD:214653	17/81 (21%)
		Ig	656..734	CDD:143165	17/77 (22%)
		FN3	741..848	CDD:238020	22/95 (23%)
side	NP_001247334.1	V-set	95..211	CDD:284989
		IG_like	100..211	CDD:214653
		Ig	235..301	CDD:299845	4/7 (57%)
		Ig	326..408	CDD:299845	24/89 (27%)
		IG_like	329..407	CDD:214653	24/85 (28%)
		IG_like	435..511	CDD:214653	21/75 (28%)
		Ig_2	442..511	CDD:290606	20/68 (29%)
		FN3	<700..735	CDD:238020	4/34 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810