DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ed and nrm

DIOPT Version :10

Sequence 1:NP_523469.2 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster
Sequence 2:NP_001246890.1 Gene:nrm / 40515 FlyBaseID:FBgn0262509 Length:2192 Species:Drosophila melanogaster


Alignment Length:1619 Identity:314/1619 - (19%)
Similarity:547/1619 - (33%) Gaps:478/1619 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 RSARRAATTIC---------NFFLIALVAL--SSTTLADESIDTRENADLTLKCRFNDKYEANDF 69
            :||:..|.:.|         :..|:..:||  |||...|.:|..:|:..:.|.|..:.:......
  Fly     8 QSAKDVAKSNCVAVRSSISLSLVLVLCLALVDSSTAQVDTTISQQESQSVVLPCPVDAEKCGKLH 72

  Fly    70 SFFW--------------TRWTANPAQFD----------NVAIGEVQLS---------------- 94
            |..|              :..|:...:||          .:.|.:::::                
  Fly    73 SLNWFKGDDRIAAMLLGDSNVTSVNKEFDERVTVEQNPYRLVIKDLKIADEDIYLCDTTFFIPEE 137

  Fly    95 -----SGYRLDF---------------------------------------------QPE----R 105
                 :|||::.                                             |||    |
  Fly   138 TCDNFNGYRIELRVLVPPTEVVILDAKGDRIKNGSVVGPMQERQSLKATCTVRNTRPQPEVSWFR 202

  Fly   106 GIYDLQIKNVSYNRDNGRF-------------------ECRIKAKGTGADVHQEFHNLTVLTPPH 151
            |...|...:.:::..:|.:                   |||:|:..        ..|:||.....
  Fly   203 GTKRLTTYSPTHDLVDGLYTSTLELDWTLSREDLAQDIECRVKSAA--------IQNVTVTKFSV 259

  Fly   152 PPVISPGNIAV------ATEDKPMELTCSSIGGSPDPTITWYREGSNTPLPATVLKGGTKDQP-- 208
            ...:.|.:|.:      ..:...:.|||...|..|...:|||    ||   .|::..|..:..  
  Fly   260 DLQVRPTSIDINGVKHHTVQGSKVVLTCDIHGARPAVNLTWY----NT---TTIISSGENEITEV 317

  Fly   209 -------------TNATLSIIPRREDDGAKYKCVVRNRAM--NEGKRLEATATLNVNYYPRVEVG 258
                         |.:.|.....|.::...::|...|..:  |..|.:.:..||.|.|.|.|:|.
  Fly   318 RSKSLEKSDGTFHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTLEVLYPPVVKVS 382

  Fly   259 PENPLRVERDRTAKLECNVDAKP-KVPNVRWNRNGRFI------------SSSLVHTIHRVSVQD 310
            | :.:.........|.|...|.| .:..|.|.||...:            |.::...|.....:|
  Fly   383 P-SAITANTSEIVLLNCEYFANPASLTQVEWYRNDILVNVNDTTHYKGGNSENVALVIKSTEKED 446

  Fly   311 AGKYTCIADNGLGK-TGEQELILDILYPPMVVI----ESKTREAEEGDTVTIRCNV-TANPAPVT 369
            .|.|:|...|.:|| |.:|::.||:.|.|.|.|    |...:|::|.: ||:.||| .|||:.:|
  Fly   447 IGNYSCQLSNNIGKGTSDQKINLDVQYAPTVEILMIPEGPVKESDESN-VTLFCNVLDANPSVLT 510

  Fly   370 -IEW------LKENSPD--------FRYNGDVLTLTSVRADHAGNYICRAVNIM----QSQGMER 415
             :.|      ||| .||        ...:...|.|.|:......||.|...|..    :|:..| 
  Fly   511 KVRWYANSTLLKE-LPDCEETREDLCHIDPSKLLLESIGRGFFYNYSCEGFNAAGWGPRSEDKE- 573

  Fly   416 SERVGNSTVALLVRHRPGQAYITPNKPVVHV-GNGVTLTCSANPPGWPVP-QYRWFRDMDGEFSS 478
                      |||.:.||.|.:: :.|:|.| ...||.:||.:.||:|.. ::||.|   |....
  Fly   574 ----------LLVHYEPGPAALS-HFPLVAVKKKSVTFSCSVDDPGFPESNRFRWLR---GGRGP 624

  Fly   479 TQKILAQGPQYSIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTRRVADT 543
            .|.|:.:  .:::....|.:...|.|:|.||.|.|:|||:.||:|.||.|:..|..:.....:..
  Fly   625 LQDIVTK--DWTVEPVGLDSRTNYSCYAYNEGGKGVMATVNLEVHAPPFFIKNLPPYTGILHSSP 687

  Fly   544 DYTVTCSAKGKPAPSVKWLKDAVEILPEENLYEVQ-----TNPDQG-LNGMVTVQSQLKFRGKAR 602
            :.|:||..:..|...:.|.||.|.|...::.|.::     .:|..| ...|::|   |.|.....
  Fly   688 NATLTCRIECVPRCDISWQKDGVPIERNDSRYFIKEKYMDASPATGDFESMLSV---LHFNMPNW 749

  Fly   603 PNGNALVPGDRGLYTCLYQNEV--NSANSSMQLRIEHEPIVLHQYNKVAFDIRET--AEVVCKVQ 663
            |:....:..|...|:|:....:  .|..|.....||:.|........:.:...:|  ..|:||.:
  Fly   750 PDSKFNIEADNANYSCVSTGNIVGGSIRSRTYFGIEYAPENTTVSENIVYVQEDTIPGRVICKSR 814

  Fly   664 AYPKPEFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDT 728
            |.|:|.::|.|.|.    |:::.....|:|..:.|               |.|.|||...|.   
  Fly   815 ANPEPSYKWIFKNE----TIANGNALIINTAMNRN---------------DDGTYTCLAYNK--- 857

  Fly   729 IRAPIRLQQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYRRVAMPR---EEQLI 790
                                     |.           ..::||...|.::    ||   |.|.|
  Fly   858 -------------------------HG-----------SSIAKTVIKVQFK----PRCEIERQEI 882

  Fly   791 PD-----CATLAN---SNSAWV-----EVDCQRDIPCKVTALEQ-----HQSYA----FKVKALN 833
            .|     |....|   ::.:|.     |.|.......|..::|:     ...||    ::..|.|
  Fly   883 DDQDTLICTAYGNPIEADFSWSIKTENETDENLGSGKKENSVEKSFYILQTDYAISRTYRCVANN 947

  Fly   834 PKSDSPYSSEIMVTTKVSRIPPPLQVTYEPNT------RTLG--IDVGATCLNLVAVVESMVNAD 890
            .....|: .||.|..:::     ....:|.||      ..||  :.|...|..::.:.......|
  Fly   948 TVGYGPF-CEIEVAEQLA-----WWQLWEKNTLIILVAAILGLLLTVIVICCIIICICRRRRRQD 1006

  Fly   891 SPMAAWEVVTTM----DNLQLS--GNGPTHKEK---IIDRIIGARRVGGG-----------RALG 935
            ..:....:.:..    |.|.:|  |...:.::|   |:.....:|.:|..           ..:.
  Fly  1007 KYLTEVPINSIQSALSDQLDMSRAGRNLSTQDKCTAILPNPSSSRFIGSAPKSPPRWPIRPGVML 1071

  Fly   936 HTISEDEDDNGLNSLALE--------DENSPTVRVKLCLRTNPEHCGDYTDAEIGRPYIAEANAL 992
            |..|..:::..:|.:.::        |.:..:.::...|..:.::.......||..  ::..|..
  Fly  1072 HVSSNTKENLTVNRMTVKPNVSGNRGDMSQLSAQLSAALNGSRDNSDGTILTEISA--VSGENEA 1134

  Fly   993 ATPTLIAIIVSCVVFALFAGLILMFCRCKRNQSKKSAAAKDYEMDSVRPSIVAAQQNQAPPPYYP 1057
            :..:::.:                     .|:.|.:..:....:.:....|::::.:.|      
  Fly  1135 SNLSILEV---------------------TNRKKATVPSTIRNVSTAEGEIISSKTHSA------ 1172

  Fly  1058 ASGLDNKALEHSMDLALSMEDQKT----------------ALYATQNGYSYHPGSGVVGVGMGGG 1106
                .:.||:|...|.....|.:|                .|.|.::...:.....:.|:...|.
  Fly  1173 ----GHIALDHVWSLIFKKSDDRTRDSQRSHVGLLQTFWRGLGAKESTSGFESQHRLKGIRCSGS 1233

  Fly  1107 VVGVGVGGSVVSGMGGGVGGIGGSGVGVNGI-PGLSAHTMPGNEWVNMGYM---ENNYSNS---- 1163
            |.......:|.|.......|........|.. |.:|.......|.....::   |.|.|::    
  Fly  1234 VTYKKAKETVHSTSDAASNGESSLTKRPNNCQPSVSIQLQSNMEEKTSKFVLKDERNNSSTEVEN 1298

  Fly  1164 ---------NNGGSVNSQD----SLWQVK--MSAAAVGNQQGMVQAP----MNQYVEQQPAYGYD 1209
                     ..|.|:.|..    |...:|  ::..:.|........|    .|:.:..:.:...:
  Fly  1299 IPCNMVPSITRGSSIESPQRPAPSSLPLKNFLNVTSWGCSGNSTMVPSHILANEQIHDKSSSLRE 1363

  Fly  1210 PLTHGGYGAVDDY--APYPHLTATPSQVGDEYHNLRNSQNPSRQDYCSDPYASVQKPKKRVDQHL 1272
            |||..|     :|  .|:..|...|::......|..|:.|..|         ..|:||:.:. ::
  Fly  1364 PLTEPG-----EYENLPFHGLQTAPNKFSTTPTNFNNNTNAVR---------VAQRPKELIG-NI 1413

  Fly  1273 DSP----YHDVSGLPNP--YNMEHLEQDEVL------------PP---QQHMSLSYDDS 1310
            :.|    |.|.....:|  |:.::....:.|            ||   |.:.||...||
  Fly  1414 NQPSVGLYQDCQATHDPLLYHQKYFCDQDALNDQRSQYTTMHRPPNNVQYNQSLFKPDS 1472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
edNP_523469.2 V-set 50..147 CDD:462230 25/209 (12%)
Ig 153..249 CDD:472250 23/118 (19%)
Ig strand B 169..173 CDD:409353 1/3 (33%)
Ig strand C 183..187 CDD:409353 1/3 (33%)
Ig strand E 211..215 CDD:409353 1/3 (33%)
Ig strand F 225..230 CDD:409353 1/4 (25%)
Ig strand G 242..245 CDD:409353 0/2 (0%)
Ig_3 253..320 CDD:464046 18/79 (23%)
Ig_3 337..406 CDD:464046 27/88 (31%)
Ig_2 437..>504 CDD:464026 18/68 (26%)
Ig 525..635 CDD:472250 26/117 (22%)
Ig strand B 545..549 CDD:409568 1/3 (33%)
Ig strand C 558..562 CDD:409568 0/3 (0%)
Ig strand E 587..591 CDD:409568 1/3 (33%)
Ig strand F 615..620 CDD:409568 2/4 (50%)
Ig strand G 628..631 CDD:409568 1/2 (50%)
Ig_3 639..724 CDD:464046 20/86 (23%)
FN3 741..848 CDD:238020 25/131 (19%)
nrmNP_001246890.1 V-set 44..152 CDD:462230 14/107 (13%)
Ig strand B 183..187 CDD:409353 0/3 (0%)
Ig <185..248 CDD:472250 11/62 (18%)
Ig strand C 197..201 CDD:409353 1/3 (33%)
Ig strand E 225..229 CDD:409353 0/3 (0%)
Ig strand F 239..244 CDD:409353 2/4 (50%)
Ig strand G 253..256 CDD:409353 2/2 (100%)
Ig 277..354 CDD:472250 16/83 (19%)
Ig strand B 283..287 CDD:409353 1/3 (33%)
Ig strand C 297..301 CDD:409353 1/3 (33%)
Ig strand E 333..337 CDD:409353 1/3 (33%)
Ig strand F 347..352 CDD:409353 1/4 (25%)
Ig_3 376..456 CDD:464046 18/80 (23%)
Ig 676..779 CDD:472250 22/105 (21%)
Ig strand B 689..693 CDD:409353 1/3 (33%)
Ig strand C 702..706 CDD:409353 0/3 (0%)
Ig strand E 734..741 CDD:409353 1/6 (17%)
Ig strand F 762..767 CDD:409353 2/4 (50%)
Ig <811..869 CDD:472250 21/115 (18%)
Ig strand C 820..824 CDD:143205 0/3 (0%)
Ig strand F 849..854 CDD:143205 3/4 (75%)
Ig strand G 862..865 CDD:143205 0/2 (0%)
PTZ00112 1747..>1940 CDD:240274
Blue background indicates that the domain is not in the aligned region.

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