DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ed and side-V

DIOPT Version :10

Sequence 1:NP_523469.2 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster
Sequence 2:NP_611765.2 Gene:side-V / 37679 FlyBaseID:FBgn0085400 Length:1174 Species:Drosophila melanogaster


Alignment Length:1355 Identity:252/1355 - (18%)
Similarity:401/1355 - (29%) Gaps:587/1355 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 LQIKNVSYNRDNGRFECRIKAKGTGADVHQEFH---------NLTVLTPP--------HPPVISP 157
            |:|||:. ..|.|.::||:           :||         |:|||.||        |...|..
  Fly   119 LRIKNIQ-TSDAGLYKCRV-----------DFHKSPTRNWRINVTVLVPPTALTILDHHGAEIRD 171

  Fly   158 GNIAVATEDKPMELTCSSIGGSPDPTITWYRE-------------GS------------------ 191
            .......|...::|||.|.||.|.|.::|:||             ||                  
  Fly   172 QTAGPYLEGDSIDLTCLSSGGVPPPRVSWWREHALIDDSFQVLPDGSVRNVLRLKNIQRKDLLTM 236

  Fly   192 ----------------------NTPLPATVLKG-------GTKDQPT------------------ 209
                                  |.|..:.:|:|       ||:...|                  
  Fly   237 YTCQASNGHVVPALTKKVILDMNLPPLSLLLQGLNHAVIAGTRSHVTCTAIGARPPPEIIWSKAG 301

  Fly   210 --------------NATLS---IIPRREDDGAKYKCV------VRNRAMNEGKR----------- 240
                          |.|:|   :||..||:..:..|.      :.::.::||..           
  Fly   302 QIVRGATSSTSSDGNTTISELMLIPVPEDNERQVVCSISLNAGITSQQLHEGHTTVMTTLGNGHT 366

  Fly   241 ---LEATATLNVNYYPRVEV---GPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSS- 298
               |:.:..|||.:.|.|.:   .|.:|..:.:.....|||:|.|.|.:..|.|..:.:.:.|| 
  Fly   367 GLYLKDSRVLNVTHAPIVNLNLGAPLDPDNLLKGTDVYLECDVKANPAITRVEWYHSDKQLHSSR 431

  Fly   299 --------LVHTIHRVSVQDAGKYTCIADNGLGKTGEQELILDILYPPMVVIESKTREAEEGDTV 355
                    ||  :..:|....|:|.|.|.|..|.....|:.||:.|||:...||....|....|:
  Fly   432 GIIISNQTLV--LQGISKSSHGQYFCRASNLQGSVSSNEVYLDVKYPPVCKSESTIIRAALKQTI 494

  Fly   356 TIRCNVTANPAP-VTIEWLKENS-------PDFRYNGDVLTLTSVRADHAGNYICRAVNIMQSQG 412
            .|.|.|.|||.. :..:|...||       |.......|:..:.  :|.:|.|            
  Fly   495 NITCEVDANPVDNLNYKWHFNNSLESLIELPQLGQGAPVMLASG--SDQSGYY------------ 545

  Fly   413 MERSERVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTCSANPPGWPVPQYRWFRDMD---- 473
             :||:|          :|..|.     .:.::|..:|......             |.|.|    
  Fly   546 -QRSKR----------KHSHGM-----QQRLLHGRHGRMAAVR-------------FEDEDEDGY 581

  Fly   474 GEFSSTQKILAQGPQYSIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTR 538
            |||                               .|.|.        |:.||  |...:..:|..
  Fly   582 GEF-------------------------------EEYGD--------EVGQP--FTQMVYSNMVH 605

  Fly   539 RVADTDYTVTCSAKGKPAPSVKWLKDAVEILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARP 603
                                    |:.||...::.  ..|.:|.|        |.|         
  Fly   606 ------------------------KNHVESSKQQQ--RKQLSPQQ--------QQQ--------- 627

  Fly   604 NGNALVPGDRGLYTCLYQNEVNSANSSMQLRIEHEP---IVLHQYNKVAFDIRETAEVVCKVQAY 665
                             |.::.|..||..   .|.|   ::|.:...||.               
  Fly   628 -----------------QQQMASGGSSGD---SHTPSGGVILERKRLVAL--------------- 657

  Fly   666 PKPEFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIR 730
               ..|...|...:|.|.::        ....|::|:..::    ::..:|..:| ||::.....
  Fly   658 ---HKQHHRGGVATPPTTTA--------APPLNNVYSYHVE----SYESFGAISC-VASSPMGHS 706

  Fly   731 AP--IRLQQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYRRVAMPREEQLIPDC 793
            ||  ..:|....||...|..|.....|.:.:...||:|||:.:......|..:    ..|:    
  Fly   707 APCWYHIQPADLPEPVKNCTAYNATANSLQIQCIPGYDGGIPQHFHAQIYDEL----NRQI---- 763

  Fly   794 ATLANSNSAWVEVDCQRDIPCKVTALEQHQSYAFKVKALNPKSDSPYSSEIMVTTKVSRIPPPLQ 858
              |.|::..:.|...:|        |.....:..::.|:|.:..|                   :
  Fly   764 --LYNASYKYSEFTVKR--------LPSDSVFVIRITAVNAQGAS-------------------K 799

  Fly   859 VTYEPNTRTLGIDVGATCLNLVAVVESMVNADSPM--AAWEVVTTMDNLQLSGNGPTHKEKIIDR 921
            |.|....|||...:..|..:...:|:.     :|:  |...|:.|:               |:..
  Fly   800 VAYRLRGRTLSAPLLRTASSTAVLVQL-----TPLLGALVGVIATL---------------ILVA 844

  Fly   922 II-----------GARRVGGG-----------------RALG-HTISED---------------- 941
            |.           |.||.|.|                 |.:| |:..||                
  Fly   845 ICVVIVIKFRSKRGGRRHGSGADATTTEADKGSAEPLSRNMGSHSSLEDKNPDVVPQEANSEDEF 909

  Fly   942 -EDDNGLNSLALEDEN---SPTVRVKLCLRTNPEHCGDYTDAEIGRPYIAEANALATPTLIAIIV 1002
             :::...:.|.:|.:.   :|..|:.......|.     .....|:.| .|.:....|       
  Fly   910 HQEEKAFDRLNMESQRILYTPPTRINTASPPPPS-----LSPTFGKQY-GELSLTTNP------- 961

  Fly  1003 SCVVFALFAGLILMFCRCKRNQSKKSAAAKDYEMDSVRPSIVAAQQNQAPPPYYPASGLDNKALE 1067
               .|:|:            |..:::.|.:       ||...      ||||             
  Fly   962 ---AFSLY------------NTPQRAPAVQ-------RPVYT------APPP------------- 985

  Fly  1068 HSMDLALSMEDQKTALYATQ---NGYSYHPGSGVVGVGMGGGVVGVGVGG----------SVVSG 1119
                           |.:|:   |.|:..||.|  |.|.|..|...|.||          |..|.
  Fly   986 ---------------LLSTRTPPNIYTRIPGRG--GGGGGATVTAAGAGGYHLPAYETRTSPTSP 1033

  Fly  1120 MG--------------------GGVGGIGGSGVGVNGIPGLSAHTMPGNEWVNMGYMENNYSNSN 1164
            .|                    |||||:||.      :.|.:.:|:|....:::|.:....::|.
  Fly  1034 YGSTTTCTMPLLGGQSNGSLQSGGVGGVGGL------VGGGACNTLPHPGSLHVGGISAALTSSV 1092

  Fly  1165 NGGSVNSQDSLWQVKMSAAAVGNQQGMVQAPMNQYVEQQPAYG--YDPLTHGGYG 1217
            ..|::              .:|..|.::.:|.:|........|  ..||..||.|
  Fly  1093 TSGNI--------------TIGAAQSLLTSPRSQTATYSTTLGGVQSPLLMGGGG 1133

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
edNP_523469.2 V-set 50..147 CDD:462230 12/45 (27%)
Ig 153..249 CDD:472250 34/210 (16%)
Ig strand B 169..173 CDD:409353 1/3 (33%)
Ig strand C 183..187 CDD:409353 0/3 (0%)
Ig strand E 211..215 CDD:409353 2/6 (33%)
Ig strand F 225..230 CDD:409353 1/10 (10%)
Ig strand G 242..245 CDD:409353 0/2 (0%)
Ig_3 253..320 CDD:464046 21/78 (27%)
Ig_3 337..406 CDD:464046 20/76 (26%)
Ig_2 437..>504 CDD:464026 8/70 (11%)
Ig 525..635 CDD:472250 15/109 (14%)
Ig strand B 545..549 CDD:409568 0/3 (0%)
Ig strand C 558..562 CDD:409568 0/3 (0%)
Ig strand E 587..591 CDD:409568 0/3 (0%)
Ig strand F 615..620 CDD:409568 0/4 (0%)
Ig strand G 628..631 CDD:409568 1/2 (50%)
Ig_3 639..724 CDD:464046 13/87 (15%)
FN3 741..848 CDD:238020 20/106 (19%)
side-VNP_611765.2 V-set 42..153 CDD:462230 12/45 (27%)
Ig_3 178..243 CDD:464046 14/64 (22%)
Ig 274..359 CDD:472250 13/84 (15%)
Ig strand B 280..284 CDD:409353 0/3 (0%)
Ig strand C 294..298 CDD:409353 0/3 (0%)
Ig strand E 320..324 CDD:409353 1/3 (33%)
Ig strand F 334..345 CDD:409353 1/10 (10%)
Ig strand G 355..358 CDD:409353 0/2 (0%)
Ig 400..466 CDD:472250 19/67 (28%)
Ig strand B 403..407 CDD:409353 1/3 (33%)
Ig strand C 416..421 CDD:409353 1/4 (25%)
Ig strand E 438..442 CDD:409353 2/5 (40%)
Ig strand F 452..457 CDD:409353 2/4 (50%)
Ig strand G 465..468 CDD:409353 0/2 (0%)
FN3 719..798 CDD:214495 19/96 (20%)

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