DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and side-V

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_611765.2	Gene:	side-V / 37679	FlyBaseID:	FBgn0085400	Length:	1174	Species:	Drosophila melanogaster

Alignment Length:	1355	Identity:	252/1355 - (18%)
Similarity:	401/1355 - (29%)	Gaps:	587/1355 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 LQIKNVSYNRDNGRFECRIKAKGTGADVHQEFH---------NLTVLTPP--------HPPVISP 157
            |:|||:. ..|.|.::||:           :||         |:|||.||        |...|..
  Fly   119 LRIKNIQ-TSDAGLYKCRV-----------DFHKSPTRNWRINVTVLVPPTALTILDHHGAEIRD 171

  Fly   158 GNIAVATEDKPMELTCSSIGGSPDPTITWYRE-------------GS------------------ 191
            .......|...::|||.|.||.|.|.::|:||             ||
  Fly   172 QTAGPYLEGDSIDLTCLSSGGVPPPRVSWWREHALIDDSFQVLPDGSVRNVLRLKNIQRKDLLTM 236

  Fly   192 ----------------------NTPLPATVLKG-------GTKDQPT------------------ 209
                                  |.|..:.:|:|       ||:...|
  Fly   237 YTCQASNGHVVPALTKKVILDMNLPPLSLLLQGLNHAVIAGTRSHVTCTAIGARPPPEIIWSKAG 301

  Fly   210 --------------NATLS---IIPRREDDGAKYKCV------VRNRAMNEGKR----------- 240
                          |.|:|   :||..||:..:..|.      :.::.::||..
  Fly   302 QIVRGATSSTSSDGNTTISELMLIPVPEDNERQVVCSISLNAGITSQQLHEGHTTVMTTLGNGHT 366

  Fly   241 ---LEATATLNVNYYPRVEV---GPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSS- 298
               |:.:..|||.:.|.|.:   .|.:|..:.:.....|||:|.|.|.:..|.|..:.:.:.||
  Fly   367 GLYLKDSRVLNVTHAPIVNLNLGAPLDPDNLLKGTDVYLECDVKANPAITRVEWYHSDKQLHSSR 431

  Fly   299 --------LVHTIHRVSVQDAGKYTCIADNGLGKTGEQELILDILYPPMVVIESKTREAEEGDTV 355
                    ||  :..:|....|:|.|.|.|..|.....|:.||:.|||:...||....|....|:
  Fly   432 GIIISNQTLV--LQGISKSSHGQYFCRASNLQGSVSSNEVYLDVKYPPVCKSESTIIRAALKQTI 494

  Fly   356 TIRCNVTANPAP-VTIEWLKENS-------PDFRYNGDVLTLTSVRADHAGNYICRAVNIMQSQG 412
            .|.|.|.|||.. :..:|...||       |.......|:..:.  :|.:|.|
  Fly   495 NITCEVDANPVDNLNYKWHFNNSLESLIELPQLGQGAPVMLASG--SDQSGYY------------ 545

  Fly   413 MERSERVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTCSANPPGWPVPQYRWFRDMD---- 473
             :||:|          :|..|.     .:.::|..:|......             |.|.|
  Fly   546 -QRSKR----------KHSHGM-----QQRLLHGRHGRMAAVR-------------FEDEDEDGY 581

  Fly   474 GEFSSTQKILAQGPQYSIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTR 538
            |||                               .|.|.        |:.||  |...:..:|..
  Fly   582 GEF-------------------------------EEYGD--------EVGQP--FTQMVYSNMVH 605

  Fly   539 RVADTDYTVTCSAKGKPAPSVKWLKDAVEILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARP 603
                                    |:.||...::.  ..|.:|.|        |.|
  Fly   606 ------------------------KNHVESSKQQQ--RKQLSPQQ--------QQQ--------- 627

  Fly   604 NGNALVPGDRGLYTCLYQNEVNSANSSMQLRIEHEP---IVLHQYNKVAFDIRETAEVVCKVQAY 665
                             |.::.|..||..   .|.|   ::|.:...||.
  Fly   628 -----------------QQQMASGGSSGD---SHTPSGGVILERKRLVAL--------------- 657

  Fly   666 PKPEFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIR 730
               ..|...|...:|.|.::        ....|::|:..::    ::..:|..:| ||::.....
  Fly   658 ---HKQHHRGGVATPPTTTA--------APPLNNVYSYHVE----SYESFGAISC-VASSPMGHS 706

  Fly   731 AP--IRLQQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYRRVAMPREEQLIPDC 793
            ||  ..:|....||...|..|.....|.:.:...||:|||:.:......|..:    ..|:
  Fly   707 APCWYHIQPADLPEPVKNCTAYNATANSLQIQCIPGYDGGIPQHFHAQIYDEL----NRQI---- 763

  Fly   794 ATLANSNSAWVEVDCQRDIPCKVTALEQHQSYAFKVKALNPKSDSPYSSEIMVTTKVSRIPPPLQ 858
              |.|::..:.|...:|        |.....:..::.|:|.:..|                   :
  Fly   764 --LYNASYKYSEFTVKR--------LPSDSVFVIRITAVNAQGAS-------------------K 799

  Fly   859 VTYEPNTRTLGIDVGATCLNLVAVVESMVNADSPM--AAWEVVTTMDNLQLSGNGPTHKEKIIDR 921
            |.|....|||...:..|..:...:|:.     :|:  |...|:.|:               |:..
  Fly   800 VAYRLRGRTLSAPLLRTASSTAVLVQL-----TPLLGALVGVIATL---------------ILVA 844

  Fly   922 II-----------GARRVGGG-----------------RALG-HTISED---------------- 941
            |.           |.||.|.|                 |.:| |:..||
  Fly   845 ICVVIVIKFRSKRGGRRHGSGADATTTEADKGSAEPLSRNMGSHSSLEDKNPDVVPQEANSEDEF 909

  Fly   942 -EDDNGLNSLALEDEN---SPTVRVKLCLRTNPEHCGDYTDAEIGRPYIAEANALATPTLIAIIV 1002
             :::...:.|.:|.:.   :|..|:.......|.     .....|:.| .|.:....|
  Fly   910 HQEEKAFDRLNMESQRILYTPPTRINTASPPPPS-----LSPTFGKQY-GELSLTTNP------- 961

  Fly  1003 SCVVFALFAGLILMFCRCKRNQSKKSAAAKDYEMDSVRPSIVAAQQNQAPPPYYPASGLDNKALE 1067
               .|:|:            |..:::.|.:       ||...      ||||
  Fly   962 ---AFSLY------------NTPQRAPAVQ-------RPVYT------APPP------------- 985

  Fly  1068 HSMDLALSMEDQKTALYATQ---NGYSYHPGSGVVGVGMGGGVVGVGVGG----------SVVSG 1119
                           |.:|:   |.|:..||.|  |.|.|..|...|.||          |..|.
  Fly   986 ---------------LLSTRTPPNIYTRIPGRG--GGGGGATVTAAGAGGYHLPAYETRTSPTSP 1033

  Fly  1120 MG--------------------GGVGGIGGSGVGVNGIPGLSAHTMPGNEWVNMGYMENNYSNSN 1164
            .|                    |||||:||.      :.|.:.:|:|....:::|.:....::|.
  Fly  1034 YGSTTTCTMPLLGGQSNGSLQSGGVGGVGGL------VGGGACNTLPHPGSLHVGGISAALTSSV 1092

  Fly  1165 NGGSVNSQDSLWQVKMSAAAVGNQQGMVQAPMNQYVEQQPAYG--YDPLTHGGYG 1217
            ..|::              .:|..|.::.:|.:|........|  ..||..||.|
  Fly  1093 TSGNI--------------TIGAAQSLLTSPRSQTATYSTTLGGVQSPLLMGGGG 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	12/45 (27%)
		I-set	146..249	CDD:254352	39/225 (17%)
		Ig	168..249	CDD:299845	32/195 (16%)
		IGc2	268..323	CDD:197706	18/63 (29%)
		Ig_3	341..406	CDD:290638	18/72 (25%)
		Ig_2	437..514	CDD:290606	10/80 (13%)
		I-set	526..633	CDD:254352	14/106 (13%)
		Ig	546..632	CDD:143165	12/85 (14%)
		IG_like	654..736	CDD:214653	12/83 (14%)
		Ig	656..734	CDD:143165	12/79 (15%)
		FN3	741..848	CDD:238020	20/106 (19%)
side-V	NP_611765.2	Ig	42..153	CDD:299845	12/45 (27%)
		IG_like	42..152	CDD:214653	11/44 (25%)
		IGc2	179..245	CDD:197706	14/65 (22%)
		IG_like	179..245	CDD:214653	14/65 (22%)
		Ig	<282..348	CDD:299845	9/65 (14%)
		IGc2	400..459	CDD:197706	17/60 (28%)
		FN3	719..798	CDD:214495	19/96 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810