DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ed and kirre

DIOPT Version :9

Sequence 1:NP_001260013.1 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster
Sequence 2:NP_001245505.1 Gene:kirre / 31292 FlyBaseID:FBgn0028369 Length:956 Species:Drosophila melanogaster


Alignment Length:1240 Identity:267/1240 - (21%)
Similarity:402/1240 - (32%) Gaps:463/1240 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 LTLKCRFNDKYEANDFSFFWTRWTANPAQFDNVAIGEVQLSSG---YRLDFQPERGIYDLQIKNV 115
            :||.||..:|..|       .:||.     |:..:|:.:..||   |.:....|.|.:.|.|..:
  Fly    99 VTLPCRVMEKVGA-------LQWTK-----DDFGLGQHRNLSGFERYSMVGSDEEGDFSLDIYPL 151

  Fly   116 SYNRDNGRFECRIKAKGTGAD----VHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTCSSI 176
            ..: |:.:::|::   |.|..    :...|..||||.||..|.|:.|:..|.|||:.:||.|.|.
  Fly   152 MLD-DDAKYQCQV---GPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIELECVSQ 212

  Fly   177 GGSPDPTITWYREGSNTPLPATV--LKGGTKDQ---PTNATLSIIPRREDDGAKYKCVVRNRAMN 236
            ||.|...|||. :|....|...:  :|....|.   ...:.|.:.|::|.....:.|..:|.|  
  Fly   213 GGKPAAEITWI-DGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTA-- 274

  Fly   237 EGKRLEATATLNVNYYPRVEV--------GPENPLRVERDRTAKLECNVDAKPKVPNVRWNRN-- 291
            :.....|...|.|.|.|:|.|        |.:.|...|    ..|.|..||.|...:.||..|  
  Fly   275 DRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAE----VILSCQADANPHELSYRWFINDE 335

  Fly   292 ---GRFISSSLVHTIHRVSVQDAGKYTCIADNGLGKTGEQELILDILYPPMVVIESKTREAEEGD 353
               |.|.:..::|.:.| ...|| ...|...|.:||: ||...|||.:.|:......:.||:.|.
  Fly   336 LMTGDFTTKMIIHNVSR-QYHDA-IVKCEVVNAVGKS-EQSKKLDISFGPVFRQRPVSVEADLGA 397

  Fly   354 TVTIRCNVTANPAPVTIEWLKENSPDFRYNGDVLTLTSVRADHAGNYICRA-VNIMQSQGMERSE 417
            ||::||:|..||.| .|||:.|||.........|.| .|.::.||.|.|:| ||.....|.|   
  Fly   398 TVSMRCDVAGNPEP-EIEWISENSDQVVGVAAELKL-KVSSETAGRYFCKAVVNGFPEIGAE--- 457

  Fly   418 RVGNSTVALLVRHRPGQAYITPNK-PVVHVGNGVTLTCSANPPGWPVPQYR---WFRDMDGE--- 475
                  ..|.|:..|   .||.:| ....||..|.:.|.|    :.:|:..   |  ..:|:   
  Fly   458 ------ATLYVKRAP---IITSHKVQFGGVGGRVKIDCLA----FSIPKAEHILW--SFEGKIIN 507

  Fly   476 FSSTQKILAQGPQYSIPK-------------AHLGNEGKYHCHAVNEL-GIGMMATIVLEIHQPP 526
            .||....:....::.:|:             .|.   |||:|..:|.. |..::.|::.|....|
  Fly   508 MSSADPDIYIFEEHHLPEGVRAALIIRDSKATHF---GKYNCTVMNSYGGDSLVITLLREPGNIP 569

  Fly   527 QFLAKLQQ----------------HMTRRVADTDYTVTCSAKGKPAPSVKWLKDAVEILPEENLY 575
            ..|..:..                :..||           ::.||.|:        :::||.:  
  Fly   570 VLLVVMGSMFCVAIILMIVMIIIVYRKRR-----------SRKKPMPA--------DVIPEAS-- 613

  Fly   576 EVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRGLYTCLYQNEVNSANSSMQLRIEHEPI 640
                                  ||           ||:       .||:.|     :||.:    
  Fly   614 ----------------------RG-----------GDK-------LNELKS-----ELRSK---- 629

  Fly   641 VLHQYNKVAFDIRETAEVVCKVQAYPKPEFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVL 705
                    |:|: |.:|.                         ..||                 |
  Fly   630 --------AYDV-EYSEA-------------------------GGDG-----------------L 643

  Fly   706 KINSLTHSDYGEYTCRVANTLDTIRAPIRLQQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGLS 770
            .|| ||.|...:...:.|    |:..|:    .||                  :.:|..|.|...
  Fly   644 AIN-LTQSPMPDVQMKGA----TLGVPL----AGP------------------VKFDERFSGDFG 681

  Fly   771 KTKFFVSYRRVAMPREEQLIPDCATLANSNSAWVEVDCQRDIPCKVTALEQHQSYAFKVKALNPK 835
            ..:    |.|                                .|.:..|:..|..|:|.   :|:
  Fly   682 GDR----YNR--------------------------------QCHIKNLKNQQETAYKG---SPQ 707

  Fly   836 SDSPYSSEIMVTTKVSRIPPPLQVTYEPNTRTLGIDVGATCLNLVAVVE----SMVNADSPMAAW 896
            ::. |:.........|   ||            |.:..|..:....|.:    .|.:|..|.:|.
  Fly   708 ANG-YAHYFEYALDYS---PP------------GGEGAAVVVGSGGVGKLKNGGMNSATLPHSAA 756

  Fly   897 EVVTTMDNLQLSGNGPTHKEKIIDRIIGARRVGGGRAL----GHTISEDEDDNGLNSLALEDENS 957
            ..|          ||            |....|||.:|    .|.|.:.:..||.....|. :|.
  Fly   757 ATV----------NG------------GGAGNGGGASLPRNQRHEIQQSQQSNGFLGQPLL-QNG 798

  Fly   958 PTVRVKLCLRTNPEHCGDYTDAEIGRPYIAEANALATPTLIAIIVSCVVFALFAGLILMFCRCKR 1022
            ...|.               .|..|.||:...::|..|.                          
  Fly   799 IDSRF---------------SAIYGNPYLRTNSSLLPPL-------------------------- 822

  Fly  1023 NQSKKSAAAKDYEMDSVRPSIVAAQQNQAPPPYYPASGLDNKALEHSMDLALSMEDQKTALYATQ 1087
                            ..||........|||||                            :|.:
  Fly   823 ----------------PPPSTANPAATPAPPPY----------------------------HAAR 843

  Fly  1088 NGYSYHPGSGVVGVGMGGGVVGVGVGGSVVSGMGGGVGGI--GGSGVGVNGIPGLSAHTMPGNEW 1150
            :|:::|...|:... :||.|:.....|:|....|||.|..  ||.||||    |::|        
  Fly   844 HGHAHHANGGLKHF-VGGAVITTSPVGNVNINGGGGGGSTPSGGGGVGV----GVAA-------- 895

  Fly  1151 VNMGYMENNYSNSNNGGSVN---SQDSLWQVKMSAAAVGNQQGMVQAPMNQYVEQQPAYGY---D 1209
                      ..|.:|.|.|   |.::|....::...|||.....|:|..|::......|:   .
  Fly   896 ----------GGSVSGSSSNLTASSNTLAATPLAGGGVGNSGQCAQSPSGQFILSNNGKGHTQKG 950

  Fly  1210 PL-TH 1213
            || ||
  Fly   951 PLATH 955

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
edNP_001260013.1 Ig 50..147 CDD:299845 24/99 (24%)
I-set 146..249 CDD:254352 33/107 (31%)
Ig 168..249 CDD:299845 22/85 (26%)
IGc2 268..323 CDD:197706 16/59 (27%)
Ig_3 341..406 CDD:290638 25/65 (38%)
Ig_2 437..514 CDD:290606 21/97 (22%)
I-set 526..633 CDD:254352 16/122 (13%)
Ig 546..632 CDD:143165 12/85 (14%)
IG_like 654..736 CDD:214653 13/81 (16%)
Ig 656..734 CDD:143165 12/77 (16%)
FN3 741..848 CDD:238020 12/106 (11%)
kirreNP_001245505.1 Ig 87..183 CDD:299845 24/99 (24%)
IG_like 88..182 CDD:214653 23/98 (23%)
C2-set_2 189..279 CDD:285423 27/92 (29%)
Ig_2 307..379 CDD:290606 24/78 (31%)
I-set 382..462 CDD:254352 31/90 (34%)
IGc2 396..446 CDD:197706 22/51 (43%)
Ig 466..561 CDD:299845 22/106 (21%)
IG_like 478..561 CDD:214653 18/91 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45451333
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR11640
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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