DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and rst

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	911	Identity:	199/911 - (21%)
Similarity:	316/911 - (34%)	Gaps:	292/911 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ADLTLKCRFNDKYEANDFSFFWTRWTANPAQFDNVAIGEVQLSSG---YRLDFQPERGIYDLQIK 113
            |.:||.||..:|    ..:..||:        |:..:|..:..||   |.:....|.|.|.|.|.
  Fly    43 ARVTLPCRVINK----QGTLQWTK--------DDFGLGTSRDLSGFERYAMVGSDEEGDYSLDIY 95

  Fly   114 NVSYNRDNGRFECRIKAKGTGAD-VHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTCSSIG 177
            .|..: |:.|::|::.....|.. :...|..||||.||..|.|:.|::..||||:.:|:.|.|:|
  Fly    96 PVMLD-DDARYQCQVSPGPEGQPAIRSTFAGLTVLVPPEAPKITQGDVIYATEDRKVEIECVSVG 159

  Fly   178 GSPDPTITWYREGSNT----------PLPATVLKGGTKDQ---PTNATLSIIPRREDDGAKYKCV 229
            |.|...|||.....|.          |||         ||   ...:.|.:.|::|.....:.|.
  Fly   160 GKPAAEITWIDGLGNVLTDNIEYTVIPLP---------DQRRFTAKSVLRLTPKKEHHNTNFSCQ 215

  Fly   230 VRNRAMNEGKRLEATATLNVNYYPRVEVGPENPL----------------------RVERDRTAK 272
            .:|.|  :.....|...:.|.|.|:|:|.....|                      |:......:
  Fly   216 AQNTA--DRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVR 278

  Fly   273 LECNVDAKPKVPNVRW---------NRNGRFISSSLVHTIHRVSVQDAGKYTCIADNGLGKTGEQ 328
            |||..||.|.....||         .:....:..::....|...|:      |...|.:||:.:.
  Fly   279 LECRADANPSDVRYRWFINDEPIIGGQKTEMVIRNVTRKFHDAIVK------CEVQNSVGKSEDS 337

  Fly   329 ELILDILYPPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYNGDVLTLT-SV 392
            | .|||.|.|......::.||:.|..|::.|.|.:||.| .|.|::.  |..|..|....|| ||
  Fly   338 E-TLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQP-EIVWIQH--PSDRVVGTSTNLTFSV 398

  Fly   393 RADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPN-------KPVVH----- 445
            ..:.||.|.|:| |:                        ||.|.|:.:       .|.:.
  Fly   399 SNETAGRYYCKA-NV------------------------PGYAEISADAYVYLKGSPAIGSQRTQ 438

  Fly   446 ---VGNGVTLTCSANPPGWPVPQYR---WFRDMDGEFSSTQKILAQGPQYSI------------- 491
               ||:...:.|.|:    .||:.|   |  ..:|:..|::    .|..|||
  Fly   439 YGLVGDTARIECFAS----SVPRARHVSW--TFNGQEISSE----SGHDYSILVDAVPGGVKSTL 493

  Fly   492 ----PKAHLGNEGKYHCHAVNELG-------------IGMMATIVLEIHQPPQFLAKLQQHMTRR 539
                .:|:  :.|||:|..||:.|             :.::.|||..| ....||..|      .
  Fly   494 IIRDSQAY--HYGKYNCTVVNDYGNDVAEIQLQAKKSVSLLMTIVGGI-SVVAFLLVL------T 549

  Fly   540 VADTDYTVTCSAKGKPAPSVKWLKDAVEILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPN 604
            :....| :.|..:.|..|:        :::.|..:.:         ||.|:.:
  Fly   550 ILVVVY-IKCKKRTKLPPA--------DVISEHQITK---------NGGVSCK------------ 584

  Fly   605 GNALVPGDRGLYTCLYQNEVNSANSSMQLRIEHEPIVLHQYNKVAFDIRETAEVVCKVQAY-PKP 668
               |.||||            ::|                |:.:..||.         ..| |..
  Fly   585 ---LEPGDR------------TSN----------------YSDLKVDIS---------GGYVPYG 609

  Fly   669 EFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIRAPI 733
            ::...:...|..||..|......||...||  :.:.|::.
  Fly   610 DYSTHYSPPPQYLTTCSTKSNGSSTIMQNN--HQNQLQLQ------------------------- 647

  Fly   734 RLQQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYRRVAMPREEQLIPDC-ATLA 797
              ||:.......:.:.|.:...:::.|     .|| |.|...:..|.:   |::..:|.. :|.|
  Fly   648 --QQQQQSHHQHHTQTTTLPMTFLTNS-----SGG-SLTGSIIGSREI---RQDNGLPSLQSTTA 701

  Fly   798 NSNSAWVEVDCQRDIPCKVTALEQH----QSYAFKVKALNPKSDSPYSSEIMVTTKVSRIPPPLQ 858
            :..|:.....|........|....|    .|.|..|   :|:..:.|.:..:.::..|.:|||..
  Fly   702 SVVSSSPNGSCSNQSTTAATTTTTHVVVPSSMALSV---DPRYSAIYGNPYLRSSNSSLLPPPTA 763

  Fly   859 V 859
            |
  Fly   764 V 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	26/98 (27%)
		I-set	146..249	CDD:254352	33/115 (29%)
		Ig	168..249	CDD:299845	22/93 (24%)
		IGc2	268..323	CDD:197706	12/63 (19%)
		Ig_3	341..406	CDD:290638	23/65 (35%)
		Ig_2	437..514	CDD:290606	24/124 (19%)
		I-set	526..633	CDD:254352	17/106 (16%)
		Ig	546..632	CDD:143165	13/85 (15%)
		IG_like	654..736	CDD:214653	11/82 (13%)
		Ig	656..734	CDD:143165	11/78 (14%)
		FN3	741..848	CDD:238020	20/111 (18%)
rst	NP_001284835.1	IG_like	34..130	CDD:214653	27/99 (27%)
		Ig	42..114	CDD:299845	22/83 (27%)
		C2-set_2	135..225	CDD:285423	28/100 (28%)
		Ig_3	265..329	CDD:290638	12/69 (17%)
		I-set	346..420	CDD:254352	29/101 (29%)
		Ig	360..425	CDD:299845	26/92 (28%)
		Ig5_KIRREL3-like	428..524	CDD:143235	23/107 (21%)
		IG_like	435..524	CDD:214653	22/100 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940