DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and Siglec1

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_017447235.1	Gene:	Siglec1 / 311426	RGDID:	1311953	Length:	1708	Species:	Rattus norvegicus

Alignment Length:	1614	Identity:	332/1614 - (20%)
Similarity:	514/1614 - (31%)	Gaps:	602/1614 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LTLKCRFNDKYEANDFSFFWTRWTANPAQFDNV---AIGEVQLSSGYRLDFQPERGIYDLQIKNV 115
            :||.||.|..|.|.. |..|.:        |.|   |.|.|                  ||:.:.
  Rat   259 VTLTCRVNSSYPAVS-SVDWVK--------DGVNLTAKGHV------------------LQLSSA 296

  Fly   116 SYNRDNGRFECRIKAKGTGADVHQEFHNLTVLTPPHPPV----------ISPGNIAVATEDKPME 170
            ::| |:|.:.|            |..:|:..|.  .||:          |:|....:  |::.:.
  Rat   297 TWN-DSGVYTC------------QATNNVGSLA--SPPLSLHVFMAEVKINPAGPIL--ENETVT 344

  Fly   171 LTCSSIGGSP-DPTITWYR-----EGSNTP---LPATVLKGGTKDQPTNATLSIIPRREDDGAKY 226
            |.||:...:| :...:||:     |.::.|   |||..                   |.|.|. |
  Rat   345 LLCSTPKEAPQELRYSWYKNNILLEDAHAPTLHLPAVT-------------------RADTGF-Y 389

  Fly   227 KCVVRNRAMNEGKRLEATATLNVNYYPRVEVGPENPLRVERDRTAKLE----------CNVDAKP 281
            .|.|:|   .:|.......::.|.|.|           :..|.|..||          |:|.::|
  Rat   390 FCEVQN---TQGSERSGPVSVVVRYPP-----------LTPDLTTFLETQAGLVGIFHCSVISEP 440

  Fly   282 KVPNV-------------RWNRNGRFISSSLVHTIHRVSVQ-----DAGKYTCIADNGLGKTGEQ 328
            ....|             ..:.|.||..||..::: |:.::     |:|:|||.|.|.|||:...
  Rat   441 LATVVLSHGGLTLASSSGENDFNPRFSISSAPNSV-RLEIRDLQPADSGEYTCSATNSLGKSMSS 504

  Fly   329 ELILDILYPPMVVIESKTREAEEGDTVTIRCNVTANPAPVT-IEW-------LKENSPDFRYNGD 385
               ||.......::.|.::|..||..||:.|....||||.| ..|       |:.:|.:|
  Rat   505 ---LDFHANVARLLISPSKEVVEGQAVTLSCRSGLNPAPDTRFSWYLNGALLLEGSSSNF----- 561

  Fly   386 VLTLTSVRADHAGNYICRA---------------------------------------------- 404
              .|.:..:..:|:|.|||
  Rat   562 --LLPAASSTDSGSYYCRARAGPHTSGPSLPTVLTVFYPPRKLTFTARLDLDTSGDGDGRRGILL 624

  Fly   405 -------------------------------------------------VNIMQSQGM---ERSE 417
                                                             ..:::.:||   |.|.
  Rat   625 CQVDSDPPAQLQLLHKGHVVATSLPSMCGSCSRRMKVSRASNSLQVEIQKPVLEDEGMYLCEASN 689

  Fly   418 RVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTCSANPPGWPVP-QYRWFRDMDGEFSSTQK 481
            .:|||:|:.....:.....|||:..::. |...:|||:........| .:.|||:        ..
  Rat   690 TLGNSSVSASFNAKATVVVITPSDTLLE-GTEASLTCNVTQEVAVSPANFSWFRN--------GV 745

  Fly   482 ILAQGPQYSI---PKAHLGNEGKYHCHAVNELGIGMMATIVLEIH---QPPQFLAKL---QQHMT 537
            :..|||..::   |.|.. :...|.|..:.:.|..:.|.:||.:.   .||:..|.|   |.||.
  Rat   746 LWTQGPLETVRLQPLART-DAAVYACRLLTDDGAQLSAPVVLSVQYAPDPPKLSALLDVGQGHMA 809

  Fly   538 RRVADTDYTVTCSAKGKPAPSVKWLKDAVEILPEENLYEVQTNPDQGLNGMVTVQS-----QLKF 597
                    ...|:....|...:...:.       |.|......|.:..:|.:..::     ||:.
  Rat   810 --------VFICTVDSYPLAHLSLFRG-------ERLLATSLEPQRLSHGRIQAKATANSLQLEV 859

  Fly   598 RGKARPNGNALVPGDRGLYTCLYQNEVNSANSSM--QLR---IEHEPIVLHQYNKVAFDIRETAE 657
            |        .|...|.|.|.|...|.:.|||||:  |:|   ::..|         :.::||...
  Rat   860 R--------ELGLEDSGNYHCEATNVLGSANSSLFFQVRGAWVQVSP---------SPELREGQA 907

  Fly   658 VV--CKVQAYPKPE---FQW-QFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDYG 716
            ||  |:|.. ..||   ::| |.|.   ||..|:                :|:|:|.:::....|
  Rat   908 VVLSCQVPT-GVPEGTSYRWFQDGR---PLQEST----------------SSILRIAAISLRQAG 952

  Fly   717 EYTCRVANTLDT----IRAPIRLQQKGPPEKPT--NLRAT---EVGHNYVSLSWDPGFDGGLSKT 772
            .|.|: |...||    :.||:.|.....|...|  .|.:|   ..||...|...||.     :..
  Rat   953 AYHCQ-AQAPDTAAASLAAPVSLHVSYTPRHVTLSALLSTGPGRYGHLVCSAQSDPP-----ALL 1011

  Fly   773 KFFVSYRRVA--MPREEQLI---PDCATLANSNSAWVEVDCQRDIPCKVTALEQHQSYAFKVKAL 832
            :.|...|.||  :...|:|.   |......:||...:|:        :.|.||...:|.  .:|.
  Rat  1012 RLFHQNRLVASTLQGPEELASSNPRLHVAVSSNELRLEI--------QFTELEDGGTYT--CEAT 1066

  Fly   833 NPKSDSPYSSEIMVTTKVSRIPPPLQVTYEPN-TRTLGIDVGATCLNLVAVVESMVNADSPMAAW 896
            |....:..:::.....        ::|...|| |...|..|..:||      ....:.||....|
  Rat  1067 NTLGQASATADFDAQA--------VRVAVWPNATVQEGQQVNLSCL------AWSTHQDSLSYTW 1117

  Fly   897 ---------------EVVTTMD------NLQLSGNGPTHKEKI-IDRIIGARRV-------GGGR 932
                           ..||..|      .:.|.|:.|.....: :|.:...|.:       ..||
  Rat  1118 YKGGQQLLGVRSISLPSVTVSDATSYRCGVGLPGHTPHLSRPVTLDVLYAPRSLQLTYLLESQGR 1182

  Fly   933 AL--------------------GHTISEDEDDNGLNSLALE-------DE-------NSPTVRVK 963
            .|                    |..::...:.:..|:|.||       ||       .||..:|.
  Rat  1183 RLALVLCTVDSRPPAQLTLSHGGQLLASSTEASVPNTLRLELQDPKPSDEGLYSCSAQSPLGKVN 1247

  Fly   964 LCL---------RTNPEHCGDYTDAEIGRP--YIAEANALATPTLIAII----------VSCVVF 1007
            ..|         |.||.     .....|.|  ...|..|..:|.|.|..          .|.:.|
  Rat  1248 TSLALRLEGVRVRMNPS-----ATVPEGEPVTVTCEDPAALSPALYAWFHNGHWLQEGPASSLQF 1307

  Fly  1008 AL----FAGLILMFCRCKRNQSKKSA---------AAKDYEMDSVRPS------IVAAQQNQAPP 1053
            .:    .||  ..||:....|..:|:         |.:|..:.|.|.|      ::....:..||
  Rat  1308 PVTTQAHAG--AYFCQVHDTQGTRSSRPASLQILYAPRDAVLSSFRDSRTRHMVVIQCTVDSEPP 1370

  Fly  1054 PYYPASGLDNKALEHSMDLALSMEDQKTALYATQNGYSYHPGSGVVGVGMGGGVVGV-----GVG 1113
                            .:|.||...:  .|.|::..:|..||...|........:.|     |.|
  Rat  1371 ----------------AELVLSRNSK--VLAASRELHSSAPGISHVQAARNALRLQVQDTTFGDG 1417

  Fly  1114 GSVVSGMGGGVGGIG-------GSGVGVNGIPGLSAHTMPGNEWVNMGYMENNYSNSNNGGS--V 1169
            .:.|......:|.|.       .:.:.|...|||.   :|....:|:       |....|||  |
  Rat  1418 NTYVCTARNTLGSISTTHKLLRETDIHVTAEPGLD---VPEGTALNL-------SCHLPGGSQPV 1472

  Fly  1170 NSQDSLW----QVKMSA--------AAVGNQQGM--VQAPMNQYVEQQPAYG----YDPLT---- 1212
            .:....|    .:..||        ..|..|.|.  .:|.::..|...|...    |.|.|
  Rat  1473 GNSSFTWFWNRHLLHSAPVPTLSFTPVVRAQAGSYHCRAELSTGVTTSPPVMLRVLYPPKTPTLT 1537

  Fly  1213 -----HGGY-GAVD---DYAPYPHLTATPSQVGDEYHNLRNSQNPSRQDYCSDPYASVQKPKKRV 1268
                 .||: |.:|   |..|...||.   |:|.:.  :.::|          |:::..:|..||
  Rat  1538 VFVEPQGGHQGILDCRVDSEPLASLTL---QLGSQL--VASNQ----------PHSAPTQPHIRV 1587

  Fly  1269 DQHLDSPYHDVSGLPNPYNMEHLEQDEVLPPQQHMSLSYDDSFEGEY-STTPNA 1321
            ..              |.|...|:.:|:.|..|           ||| .|..||
  Rat  1588 TA--------------PPNALRLDIEELGPNNQ-----------GEYVCTASNA 1616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	22/95 (23%)
		I-set	146..249	CDD:254352	25/121 (21%)
		Ig	168..249	CDD:299845	19/89 (21%)
		IGc2	268..323	CDD:197706	21/82 (26%)
		Ig_3	341..406	CDD:290638	22/167 (13%)
		Ig_2	437..514	CDD:290606	19/80 (24%)
		I-set	526..633	CDD:254352	26/116 (22%)
		Ig	546..632	CDD:143165	20/92 (22%)
		IG_like	654..736	CDD:214653	24/91 (26%)
		Ig	656..734	CDD:143165	23/87 (26%)
		FN3	741..848	CDD:238020	25/116 (22%)
Siglec1	XP_017447235.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010