DRSC/TRiP Functional Genomics Resources

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Protein Alignment ed and Cd22

DIOPT Version :9

Sequence 1:NP_001260013.1 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster
Sequence 2:NP_001100973.1 Gene:Cd22 / 308501 RGDID:1311610 Length:852 Species:Rattus norvegicus


Alignment Length:768 Identity:173/768 - (22%)
Similarity:286/768 - (37%) Gaps:157/768 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 CNFFLIALVALSSTTLA-------DESIDTRENADLTLKCRFNDKYEAN--DFSFFWTRWTANPA 81
            |.:.|:.|..::|...|       .:::...|.|.:.:.|::......:  |....:..:|    
  Rat     5 CPWLLLILGHVASFRSATGWSVEHPQTLFAWEGACIQIPCKYKVPKPRSRLDSILLFQNYT---- 65

  Fly    82 QFDNVA---IGEVQLSSGYRLDFQPERGIYDLQIKNVSY--NRDNGRFECRIKAKG--------- 132
             |||..   .|:| |.:..:...:.|  :|..|...|::  ||.|   .|.:|...         
  Rat    66 -FDNTTRDFTGKV-LYNNTKASIETE--LYFSQQDRVTFLGNRSN---NCTLKIDPIHANDSGKL 123

  Fly   133 -----TGADVHQEFHNLTVLTPPHPPVIS-PGNIAVATEDKPMELTC----SSIGGSPDPTITWY 187
                 :|.|...|..:|.|...|..|.|. |..|   .|.:.:.|||    :..|  .|.::.|.
  Rat   124 GLRLISGTDKWMEHIHLNVSERPFQPYIQLPSEI---RESQRVSLTCGLNFTCFG--YDISLRWS 183

  Fly   188 REGSNTPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYY 252
            .:||......:.:....::..|.:.|:..|:..|.|....|.|.:.:....:|   |..|:|.|.
  Rat   184 LDGSEVSPVTSSITSSVENVYTESKLTFQPKWTDHGKSMMCQVWHFSQVLSER---TVRLDVKYT 245

  Fly   253 PRVEVGPENPLRVERDRTAKLECNVD-AKPKV--PNVRWNRNGRFISSSLVH---TIHRVSVQDA 311
            |:::: ..||..|:...:..:.|.|: :.|.:  ..|.|.::|.|:......   |:|.|:....
  Rat   246 PKLQI-TVNPTEVKEGNSVTMTCQVNSSNPSLSTKKVSWFKDGSFLKEQQEQEELTLHSVTKDMR 309

  Fly   312 GKYTCIADNGLGKTGEQELILDILYPPMVVIESKTR----EAEEGDTVTIRCNVTANPAPVTIEW 372
            |||.|.|.|.:|:...:|:.|.:||||.   .||..    .||||.:|.:.|:..|:|......|
  Rat   310 GKYQCRASNNIGQGQSKEVALTVLYPPE---PSKVHIYPSPAEEGQSVELICDSLASPRATNYTW 371

  Fly   373 LKENSPDFRYNGDV--------LTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVR 429
            .        :||::        |.:::|...|||.|.|.|.|.:....:|:.        |.|..
  Rat   372 Y--------HNGEMVPGASHEKLQISNVSLWHAGKYSCLAENRLGCGKIEQE--------AELDV 420

  Fly   430 HRPGQAYITPNKPV--VHVGNGVTLTCSANPPGWPVPQYRWFRDMDGEFSSTQKILAQGPQYSIP 492
            |...:|..|..:.|  :..|:.|||.|..|.....|.:|.|.....|...:...:..|...:..|
  Rat   421 HYVPKAVTTVIQSVTPIREGDSVTLDCRYNSSNPEVTKYEWSPQGSGSEVTPGVLRIQKATWDSP 485

  Fly   493 KAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTRRV-ADTDYTVTCSAKGKPA 556
                    ...|.|.| ........:.|.:|..|:.:..|:......: |.....:.|...|...
  Rat   486 --------PIKCAACN-YKCSWSFPVSLNVHYAPRAVKILKVSPASEIHAGQHVLLQCDFSGSFP 541

  Fly   557 PSVK--WLKDAVEILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRGLYTCL 619
            ..|:  |.|:.  .|.:|..|                   |.|        :::.|.|.|.|.|:
  Rat   542 TEVRFFWKKNG--NLVQEGRY-------------------LNF--------SSISPEDSGNYNCM 577

  Fly   620 YQNEVNSANS-SMQLRIEHEPIVLHQYNKVAFDIRE--TAEVVCKVQAYPKPEFQ--WQFGNNPS 679
            .:|.:...:| :..|::.:.|..|.........:.|  .|.:.|:..|:| |.|:  | |..|..
  Rat   578 VRNSIGETSSQAWSLQVLYAPRRLRVSISPGDSVMEGKKATLSCESDAHP-PVFKYIW-FDANDQ 640

  Fly   680 PLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIRAP 732
            .|..|.                 ..|::..|.....|.|.|:..|.|.|.::|
  Rat   641 DLHFSG-----------------QKLRLEPLRVQHTGSYRCQGINELGTGKSP 676

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
edNP_001260013.1 Ig 50..147 CDD:299845 24/117 (21%)
I-set 146..249 CDD:254352 25/107 (23%)
Ig 168..249 CDD:299845 18/84 (21%)
IGc2 268..323 CDD:197706 16/60 (27%)
Ig_3 341..406 CDD:290638 21/76 (28%)
Ig_2 437..514 CDD:290606 17/78 (22%)
I-set 526..633 CDD:254352 20/110 (18%)
Ig 546..632 CDD:143165 17/88 (19%)
IG_like 654..736 CDD:214653 21/83 (25%)
Ig 656..734 CDD:143165 20/79 (25%)
FN3 741..848 CDD:238020
Cd22NP_001100973.1 Ig 24..143 CDD:416386 24/129 (19%)
FR1 24..47 CDD:409353 3/22 (14%)
Ig strand A 24..28 CDD:409353 0/3 (0%)
Ig strand A' 31..35 CDD:409353 0/3 (0%)
Ig strand B 37..48 CDD:409353 2/10 (20%)
CDR1 48..56 CDD:409353 0/7 (0%)
Ig strand C 56..63 CDD:409353 1/6 (17%)
FR2 57..63 CDD:409353 0/5 (0%)
CDR2 64..95 CDD:409353 9/38 (24%)
Ig strand C1 65..68 CDD:409353 2/7 (29%)
Ig strand C2 71..75 CDD:409353 0/3 (0%)
Ig strand C' 79..82 CDD:409353 0/2 (0%)
FR3 96..129 CDD:409353 6/35 (17%)
Ig strand D 97..101 CDD:409353 1/3 (33%)
Ig strand E 106..114 CDD:409353 3/10 (30%)
Ig strand F 121..129 CDD:409353 0/7 (0%)
CDR3 130..132 CDD:409353 1/1 (100%)
FR4 133..143 CDD:409353 2/9 (22%)
Ig strand G 133..143 CDD:409353 2/9 (22%)
IgC1_CD22_d2 147..242 CDD:409532 23/102 (23%)
Ig strand B 163..167 CDD:409532 1/3 (33%)
Ig strand C 179..183 CDD:409532 0/3 (0%)
Ig strand E 207..211 CDD:409532 1/3 (33%)
Ig strand F 221..226 CDD:409532 1/4 (25%)
Ig strand G 235..238 CDD:409532 1/5 (20%)
Ig 246..334 CDD:416386 23/88 (26%)
Ig strand A 246..253 CDD:409353 1/7 (14%)
Ig strand B 260..270 CDD:409353 1/9 (11%)
Ig strand C 277..285 CDD:409353 2/7 (29%)
Ig strand C' 287..290 CDD:409353 1/2 (50%)
Ig strand E 296..303 CDD:409353 1/6 (17%)
Ig strand F 310..318 CDD:409353 5/7 (71%)
Ig strand G 321..334 CDD:409353 3/12 (25%)
IGc2 350..408 CDD:197706 18/65 (28%)
Ig strand B 354..358 CDD:409353 1/3 (33%)
Ig strand C 367..372 CDD:409353 0/4 (0%)
Ig strand F 398..403 CDD:409353 2/4 (50%)
Ig 424..>466 CDD:416386 12/41 (29%)
Ig strand A 424..431 CDD:409353 2/6 (33%)
Ig strand A' 435..439 CDD:409353 0/3 (0%)
Ig strand B 440..450 CDD:409353 5/9 (56%)
Ig strand C 457..463 CDD:409353 2/5 (40%)
IGc2 527..583 CDD:197706 16/84 (19%)
Ig strand B 530..534 CDD:409353 0/3 (0%)
Ig strand C 543..549 CDD:409353 1/5 (20%)
Ig strand F 573..578 CDD:409353 2/4 (50%)
IG 610..682 CDD:214652 21/86 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D35531at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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