DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ed and Kirrel2

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus

Alignment Length:	515	Identity:	132/515 - (25%)
Similarity:	192/515 - (37%)	Gaps:	115/515 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 WTRWTANPAQFDNVAI-GEVQLS--SGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKAKGTG 134
            ||:        |.:|: ||..|.  |.|.:......|.:||.||.|.. .|...:||:....|..
Mouse    53 WTK--------DGLALGGERDLPGWSRYWISGNSASGQHDLHIKPVEL-EDEASYECQASQAGLR 108

  Fly   135 ADVHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTCSSIGGS-PDPTITWYREG---SNTPL 195
            :...|    |.|:.||..|.:..|.........|..|||.|.|.| |.|.:.|:|:|   ..:..
Mouse   109 SRPAQ----LHVMVPPEAPQVLGGPSVSLVAGVPGNLTCRSRGDSRPAPELLWFRDGIRLDGSSF 169

  Fly   196 PATVLKGGTKDQPTNA---TLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEV 257
            ..|.|    ||:.|..   ||.:.|...||||...|..|::|:..|:  :...||::.|.|.|.:
Mouse   170 HQTTL----KDKATGTVENTLFLTPSSHDDGATLICRARSQALPTGR--DTAVTLSLQYPPMVTL 228

  Fly   258 GPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYT----CIA 318
            ..| |..|:........|...|:|.|...||.:.|..:..:....:..|:  ||...|    |..
Mouse   229 SAE-PQTVQEGEKVTFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVA--DATFLTEPVSCEV 290

  Fly   319 DNGLGKTGEQELILDILYPPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYN 383
            .|.:| :..:...|::||.|::..:.|:...:.|...:..|....||.| .|.|.:........:
Mouse   291 SNAVG-SANRSTALEVLYGPILQAKPKSVSVDVGKDASFSCVWRGNPLP-RITWTRMGGSQVLSS 353

  Fly   384 GDVLTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPVVHVGN 448
            |..|.|.||..:.||:|:|||          ...|.|       :.....||.:|.|.|.|
Mouse   354 GPTLRLPSVALEDAGDYVCRA----------EPRRTG-------LGGGKAQARLTVNAPPV---- 397

  Fly   449 GVTLTCSANPPGW--------------PVP-QYRWFRDMDG--EFSSTQKIL-----------AQ 485
               :|.....|.:              |.| ...|..| :|  |..|..:.|           .|
Mouse   398 ---VTALQPAPAFLRGPARLQCVVFASPAPDSVVWSWD-EGFLEAGSLGRFLVEAFPAPEVEGGQ 458

  Fly   486 GPQYSIPKAHLGNEGK------YHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTRR 539
            ||.. |...|:....:      ::|.|.|.||.|                 ::|.|:.||
Mouse   459 GPGL-ISVLHISGTQESDFTTGFNCSARNRLGEG-----------------RVQIHLGRR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	21/76 (28%)
		I-set	146..249	CDD:254352	35/109 (32%)
		Ig	168..249	CDD:299845	30/87 (34%)
		IGc2	268..323	CDD:197706	13/58 (22%)
		Ig_3	341..406	CDD:290638	19/64 (30%)
		Ig_2	437..514	CDD:290606	24/110 (22%)
		I-set	526..633	CDD:254352	4/14 (29%)
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	21/75 (28%)
		Ig	122..220	CDD:416386	32/103 (31%)
		Ig strand A	123..126	CDD:409353	1/2 (50%)
		Ig strand A'	129..133	CDD:409353	0/3 (0%)
		Ig strand B	140..147	CDD:409353	4/6 (67%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	1/4 (25%)
		Ig strand C'	161..163	CDD:409353	1/1 (100%)
		Ig strand D	166..173	CDD:409353	0/6 (0%)
		Ig strand E	180..188	CDD:409353	2/7 (29%)
		Ig strand F	197..205	CDD:409353	2/7 (29%)
		Ig strand G	211..217	CDD:409353	1/7 (14%)
		Ig_3	223..292	CDD:404760	17/71 (24%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	255..259	CDD:409353	1/3 (33%)
		Ig strand E	272..275	CDD:409353	0/2 (0%)
		Ig strand F	281..290	CDD:409353	2/8 (25%)
		Ig strand G	298..301	CDD:409353	0/2 (0%)
		Ig	315..392	CDD:416386	23/94 (24%)
		Ig strand A'	316..321	CDD:409353	1/4 (25%)
		Ig strand B	324..333	CDD:409353	1/8 (13%)
		Ig strand C	339..343	CDD:409353	1/3 (33%)
		Ig strand C'	346..348	CDD:409353	0/1 (0%)
		Ig strand D	351..354	CDD:409353	0/2 (0%)
		Ig strand E	355..360	CDD:409353	1/4 (25%)
		Ig strand F	368..376	CDD:409353	5/17 (29%)
		Ig strand G	382..392	CDD:409353	2/9 (22%)
		Ig	394..498	CDD:416386	25/129 (19%)
		Ig strand A	395..399	CDD:409353	2/10 (20%)
		Ig strand A'	401..404	CDD:409353	0/2 (0%)
		Ig strand B	412..419	CDD:409353	0/6 (0%)
		Ig strand C	426..431	CDD:409353	1/4 (25%)
		Ig strand C'	433..436	CDD:409353	1/2 (50%)
		Ig strand D	444..451	CDD:409353	1/6 (17%)
		Ig strand E	461..468	CDD:409353	1/7 (14%)
		Ig strand F	479..486	CDD:409353	2/6 (33%)
		Ig strand G	489..496	CDD:409353	3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840