DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and syg-2

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_001309674.1	Gene:	syg-2 / 181561	WormBaseID:	WBGene00007750	Length:	1230	Species:	Caenorhabditis elegans

Alignment Length:	911	Identity:	199/911 - (21%)
Similarity:	311/911 - (34%)	Gaps:	263/911 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 SYNRDNGR-FECRIKAKGTGADVHQEFHNLTVLTPPHPPVI----------SPGNIAVATEDKPM 169
            |...|:|: ..|....|.|...:... ..|.||.||..|.:          |..|:.:|
Worm   198 SDRNDHGKVITCEAFQKETDIRITTN-TTLDVLFPPSDPTVEILRNPSALRSGDNVTIA------ 255

  Fly   170 ELTCSSIGGSPDPTITWYREGSNTPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRA 234
               ||..||:|.|.:.||.|.......:|:   .|:.:......|.|..:.|:.|:|:|...|..
Worm   256 ---CSVTGGNPPPDVFWYHENKRLQSHSTL---DTRSKEIKNIYSFIASQNDNMAEYECRANNSR 314

  Fly   235 MNEGKRLEATATLNVNYYP-RVEVGPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGR----- 293
            ....||  ....|.|||.| .||:..|:.:|.  ..:|.::|..........:.|..|||
Worm   315 TGNPKR--KAMKLEVNYPPASVELFGESNIRY--GSSANIQCKSLPSNPASQITWIINGRSVPTP 375

  Fly   294 ----------FISSS--LVHT------IHRVSVQDAGKYTCIADNGLGKTGEQELILDILYPPM- 339
                      .:|||  .||:      .|:::|:      |:|.|..|.:.:|. ::.|:.||.
Worm   376 TQREFVVENGIVSSSNVSVHSNELSVEAHQINVE------CMATNPEGSSAKQH-VIKIIAPPKA 433

  Fly   340 -VVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSPDF----------RYNG---DVLTLT 390
             ::...:.|:..|||.|.:.|..........:.|.:.:....          :.||   :|...:
Worm   434 PIITGLEDRKFFEGDIVNVTCEAQGGNPLAELSWYRGSEKHLVKGRKKMKWSQVNGAHNEVAGFS 498

  Fly   391 S-----VRADHAGN---YICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITP-------- 439
            |     :|.|...|   ..|.|.|....:.:..|:       .|.|.:.|.:..|.|
Worm   499 SYSTLALRVDRTMNTQRLKCEATNAALDEPLIESQ-------YLSVYYPPRRVLIRPADSGDQRL 556

  Fly   440 --------------NKPVVHVG------------------------------------------N 448
                          :.|..|:.                                          :
Worm   557 LVGKSARLVCGTLSSNPAAHISWQFSRATDDNKVHLGDVSLNETTRDNGFNVENVLSFTPTEEYD 621

  Fly   449 GVTLTCSANPPGW--------------------------------------------PVPQYRWF 469
            |..:.|.||.|.|                                            .:..::|
Worm   622 GTVVHCIANHPEWKHSVNTSFPLNVMYPPKMLVNDPVTVVMSEGDSFKENLTVRGNPAISLWQW- 685

  Fly   470 RDMDGEFSST-QKILAQGPQYSIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQ 533
            |.....|..| .::.|:|...|..:....:.|.|...|.|.:| ....||.|.:    ::.|::.
Worm   686 RKNGVPFDHTIGRVFARGAVLSGKQLLSTDAGVYTLTATNSVG-STNITIKLAV----EYSARIT 745

  Fly   534 QHMTRRVADTDYTV--TCSAKGKP--APSVKWLKDAVEILPEENLYEVQTNPDQGLNGMVTVQSQ 594
            ...|..:|.|..||  .|.|.|:|  |..:.|.|:. |||..::
Worm   746 SISTPVIAATGDTVLLECEADGEPSKANMIHWYKNG-EILAAQH--------------------- 788

  Fly   595 LKFRG--KARPNGNALVPGDRGLYTCLYQNEVN-SANSSMQLRIEHEPIVL--HQYNKVAFDIRE 654
               ||  ||....|| .....|.|||...|.:. .|.....|.:...|.||  .:|.|.|..:..
Worm   789 ---RGHKKAILRLNA-TEQQSGEYTCKADNGIGVPAEGQTFLLVNSAPRVLPVARYAKTAGILGG 849

  Fly   655 TAEVVCKVQAYPKPEFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDY-GEY 718
            .|:..|||.|.|..||.|:   ....|...:...|.|..|..:...|.|.|.|.::...|| .:.
Worm   850 VAKARCKVYAVPTVEFVWE---KDEQLIKKNSSKYSIVNTQIDYSTYESTLWIKNIVPDDYTKKV 911

  Fly   719 TCRVANTLDTIRAPIRLQQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYRRVAM 783
            .|...|:..|....|.:.....|::|.||..|....|.:|::|:|.|||| |...|.|.|||
Worm   912 KCIARNSFGTDHLSIPIIPPTHPDEPFNLTMTNSTLNTISVAWEPRFDGG-SDQIFEVKYRR--- 972

  Fly   784 PREEQLIPDCATLANSNSAWVEVDCQRDIPCKVTALEQHQSYAFKVKALNPKS-DSPYSSEIMVT 847
             :.:.||    .|.|:...          ..:::.|....:|.|:::::|.:. .|.::|.::..
Worm   973 -QNDDLI----HLVNTTHT----------NLRLSGLATANTYFFQIRSINARGFASSWTSPVIFA 1022

  Fly   848 T 848
            |
Worm  1023 T 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	7/31 (23%)
		I-set	146..249	CDD:254352	29/112 (26%)
		Ig	168..249	CDD:299845	21/80 (26%)
		IGc2	268..323	CDD:197706	16/77 (21%)
		Ig_3	341..406	CDD:290638	16/85 (19%)
		Ig_2	437..514	CDD:290606	22/185 (12%)
		I-set	526..633	CDD:254352	28/113 (25%)
		Ig	546..632	CDD:143165	24/92 (26%)
		IG_like	654..736	CDD:214653	23/82 (28%)
		Ig	656..734	CDD:143165	22/78 (28%)
		FN3	741..848	CDD:238020	29/107 (27%)
syg-2	NP_001309674.1	IG_like	25..105	CDD:214653
		Ig	33..122	CDD:299845
		Ig	147..228	CDD:299845	7/30 (23%)
		IGc2	248..313	CDD:197706	20/76 (26%)
		Ig	450..537	CDD:299845	15/93 (16%)
		Ig	559..632	CDD:299845	6/72 (8%)
		I-set	657..738	CDD:254352	15/82 (18%)
		Ig	665..738	CDD:299845	15/74 (20%)
		IG_like	748..828	CDD:214653	28/105 (27%)
		IGc2	756..817	CDD:197706	23/86 (27%)
		Ig	845..922	CDD:299845	21/79 (27%)
		FN3	934..1023	CDD:238020	29/107 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910