DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and igcm-1

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_508166.1	Gene:	igcm-1 / 180433	WormBaseID:	WBGene00018215	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	1150	Identity:	287/1150 - (24%)
Similarity:	462/1150 - (40%)	Gaps:	205/1150 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 FFLIALVALSSTTLADES-IDTRE-----------NADLTLKC----RFND--KYEANDFSFFWT 74
            |||..|..:..|..||.| :..:|           |..:.:.|    .:.|  |||.|     |.
Worm     7 FFLFFLFLVQLTNSADSSDVFLKEPSSEPYFLQEGNEGIVIPCVVKPEYFDRQKYEIN-----WA 66

  Fly    75 RWTANPAQFDNVAIGEVQLS---SGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKAKGT-GA 135
            |:  |..|...:...:..|:   |.:.|:.....|.|.|:|..|..|...|.:.|.:  .|| .:
Worm    67 RY--NNGQLRMITKNDKLLAKKHSRFILENDSATGNYSLRITEVEKNSVEGTYHCNV--IGTDDS 127

  Fly   136 DV-HQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTCSSIGGSPDPTITWYREGSNTPLPATV 199
            || :.....:.||.||..|:||........|...|...|.|:||||.||.||... ::|...:.:
Worm   128 DVQYSALATVVVLVPPGDPIISTTPSESVIEGDFMTAKCVSVGGSPQPTFTWTLP-NDTIASSAI 191

  Fly   200 LKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEA-TATLNVNYYPRVEVGP-EN- 261
            .....:|..|.:.|.......|||...:|.|.||||..|:..:. ::.|||.|.|.|.|.| ||
Worm   192 FTTQFRDGATESLLHFRVTSSDDGKSVQCDVTNRAMLGGETKQVKSSQLNVLYKPVVFVTPTENL 256

  Fly   262 -PLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISS-----SLVHTIHRVSVQDAGKYTCIADN 320
             .|.||......|.||..:.|...:..|    :.|:|     ..:..| ||....:|.:.|.:.|
Worm   257 THLSVEEGELVNLTCNSASNPPAHSYEW----KHIASGERYQGKIWPI-RVDSSMSGDFECRSTN 316

  Fly   321 GLGKTGEQELILDILYPPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYNGD 385
            .||: |...|.:.:.:.|.:.:.......|..| :.|.|.|:|.|..:.|:|:..|.  |:.||.
Worm   317 ELGE-GTAVLKMVVQHIPRINVPESISPNEMED-IDILCEVSAVPEVIDIKWVGPNG--FKQNGS 377

  Fly   386 VLTLTSVRADHAGNYICRAVNIMQSQGMERS-ERVGNSTVALLVRHRPGQAYITPNKPVVHVGNG 449
            .||:||:....:|||.|.|.|.:...|...| :|:|..|..:.|:.:||||.|...:..|.||..
Worm   378 RLTITSISKAQSGNYTCMATNFLTVYGHSGSQQRMGTGTTIVDVKRKPGQAQIVSARQNVDVGET 442

  Fly   450 VTLTCSANPPGWPVPQYRWFRDMDGEF----SSTQKILAQGPQYSIPKAHLGNEGKYHCHAVNEL 510
            :.|.|.|...|.|...|.|.....|..    ..|:|      .:.:..|.|.:.|.|.|.|.|:|
Worm   443 IKLMCQAEDAGNPSASYTWASPSSGGIFGLEGHTEK------SFEVRNAQLSDNGVYSCKAYNDL 501

  Fly   511 GIGMMATIVLEIHQPPQFLAKLQQHMTRRVADTDYTVTCSAKGKPAPSVKWLKDAVEILPEENLY 575
            |.|.:.|:::.:.:..:..:.|.........:....:.|.|:|.|:|.:|||||...:  ::::|
Worm   502 GEGKIGTVMITVIEKARISSPLATERIFTSGEQGKILECEAQGYPSPVIKWLKDGRPV--KQSIY 564

  Fly   576 ------EVQTNPD----QGLNGMVTVQSQLKFRGKARPNGNALVPGDRGLYTCLYQN---EVNSA 627
                  |.:..|:    |.:...:|:...||:             .|:|.:||:..|   :.:..
Worm   565 ASSATSESKCLPEDFCTQTVASTLTLAGPLKW-------------SDKGNFTCVADNGSDKTDKD 616

  Fly   628 NSSMQL-RIEHEPIVLH----QYNKVAFDIRETAEVVCKVQAYPKPEFQWQFGNNPSPLTMSSDG 687
            :||..: |:.|:|:.|:    :.:..|.||...|.:.|||.|.|:|||.|.|.::    .:|.:.
Worm   617 SSSWTIVRVLHKPVFLNRKFPEKSLAAADIGSQAIIRCKVSARPEPEFHWMFRDS----EISENE 677

  Fly   688 HYEISTT--TDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIRAPIRLQQKGPPEKPTNLRAT 750
            .:...|.  |...|.|..:|:|.|:..||||||.||..|........|.|::..||..|.:|:..
Worm   678 RHSFHTVGITGKPDEYEQLLQIESVQESDYGEYVCRATNGNGGDHVVIELRKTSPPALPLDLQKL 742

  Fly   751 EVGHNYVSLSWDPGFDGGLSKTKFFVSYRRVAMPREEQLIPDCATLANSNSAWVEVDCQRD--IP 813
            ....|.|.|.|.|.||||..:| :.:..|::.....|  |...|.::..|...|:.|.:.|  :.
Worm   743 SATSNSVLLGWVPQFDGGADQT-YVLETRKIDPFTGE--IDGNAPVSKLNINAVQQDQEIDGTLV 804

  Fly   814 CK----VTALEQHQSYAFKVKALNPKSDSPYSSEIMVTT----KVSRIPPPLQVTYEPNTRTLGI 870
            .|    .|.|....:|..:::|::.|.:|.::..::.:|    :.:.:..|.::..:.:.:.:.:
Worm   805 SKNIFNFTGLTPLSTYNLRIQAVSEKGESEFTPVLIASTEDVVEDANMMSPSRLVLDSSEQKINV 869

  Fly   871 D---VGATCLNLVAVVESMVNADSPMAAWEVVTTMDNLQLSGNGPTHKEKIIDRIIGARRVGGGR 932
            :   ....|..|...::.:         |...|...:....||           ||..|.
Worm   870 EPKLPSDACTLLYVFLDGI---------WRTSTCHTSSNPIGN-----------IIPGRE----- 909

  Fly   933 ALGHTISEDEDDNGLNSLALEDENSPTVRVKLCLRTNPEHCGDYTDA-EIGRPYIAEANALATPT 996
                                       .|.:.|...|...|...:.. ..|...:.:.|.. .|.
Worm   910 ---------------------------YRARFCTTANGLKCSPVSKTISSGSGSVWKTNVF-FPF 946

  Fly   997 LIAIIVSCVVFALFAGLILMFCRCKRN-----------------QSKKSAAAKDYEMDSVRPSIV 1044
            |..|.:...:...|    |:.|:.:.|                 :.|:.|   |||  ..:.:..
Worm   947 LFFIFIGLAICVFF----LVCCKTRSNPKTSKLSPIILTSLPGDELKRPA---DYE--EPKHATF 1002

  Fly  1045 AAQQNQAPPPYYPASGLDNKALEHSMDLALSME-DQKTALYATQN 1088
            |..:|:       .:.|.....:.:....|:|| |..|..|..:|
Worm  1003 AITENE-------TNHLSQHDAKSTKPPGLNMEYDVSTDCYLQEN 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	27/118 (23%)
		I-set	146..249	CDD:254352	34/103 (33%)
		Ig	168..249	CDD:299845	26/81 (32%)
		IGc2	268..323	CDD:197706	13/59 (22%)
		Ig_3	341..406	CDD:290638	22/64 (34%)
		Ig_2	437..514	CDD:290606	23/80 (29%)
		I-set	526..633	CDD:254352	25/119 (21%)
		Ig	546..632	CDD:143165	24/98 (24%)
		IG_like	654..736	CDD:214653	29/83 (35%)
		Ig	656..734	CDD:143165	28/79 (35%)
		FN3	741..848	CDD:238020	28/112 (25%)
igcm-1	NP_508166.1	Ig	45..119	CDD:299845	20/80 (25%)
		Ig	146..226	CDD:299845	25/80 (31%)
		Ig_3	245..316	CDD:290638	21/75 (28%)
		IG_like	258..329	CDD:214653	20/76 (26%)
		IG_like	338..398	CDD:214653	22/62 (35%)
		IGc2	347..398	CDD:197706	21/53 (40%)
		Ig_2	429..513	CDD:290606	25/89 (28%)
		IG_like	437..513	CDD:214653	24/81 (30%)
		Ig	537..615	CDD:143165	22/92 (24%)
		IG_like	644..728	CDD:214653	31/87 (36%)
		IGc2	646..719	CDD:197706	29/76 (38%)
		FN3	733..843	CDD:238020	28/112 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158669
Domainoid	1	1.000	57	1.000	Domainoid score	I7238
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H76706
Inparanoid	1	1.050	276	1.000	Inparanoid score	I1776
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	1	1.000	-	-		FOG0008560
OrthoInspector	1	1.000	-	-		otm14409
orthoMCL	1	0.900	-	-		OOG6_112354
Panther	1	1.100	-	-	O	PTHR11640
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17054
SonicParanoid	1	1.000	-	-		X7644
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790