DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and malt-1

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_495424.2	Gene:	malt-1 / 174135	WormBaseID:	WBGene00017702	Length:	639	Species:	Caenorhabditis elegans

Alignment Length:	726	Identity:	135/726 - (18%)
Similarity:	214/726 - (29%)	Gaps:	270/726 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 LPATVLKGGTKD-QPTNATLSIIPRREDD------------GAKYKC---VVR---NRAMNEGKR 240
            ||..:.|..::: |..|..:.|:...||.            ..:.||   |:|   ||....|..
Worm     8 LPVRIFKILSEELQKDNIWIKIVEFDEDPIYYMKSTEIESFLKREKCCEQVLRKWGNRGQTVGSL 72

  Fly   241 LEATATLNVNYYPRVE----------------VGPENPLRVERDR-TAKLECNVDAKPKVPNVRW 288
            |.....|:..|....:                ..||..:..|.|. ..||||.....| .|.::|
Worm    73 LARLQFLSRTYEDEFDSIQFHLRRKFKPLRWIPDPEQQVTKEIDEGNIKLECKAQGFP-CPEIKW 136

  Fly   289 NRNGRFISSSLVH-----TIHRVSVQDAGKYTCIADNGLGKTGEQELILDILYPPMVVIESKTRE 348
            ...|   |...||     ||.|....:..:|.|:|.|                           |
Worm   137 FTKG---SKEPVHIGRVYTILRCKCSNEHQYKCVAKN---------------------------E 171

  Fly   349 AEEGDTVTIRCNVTANPAPVTIEWLKENSPDFR--YNGDVLTLTS-VRADHAGNYICRAVNIMQ- 409
            ..||...:              |..::....|.  ...:.:.:|| :|.|.    :|.:....:
Worm   172 IREGSPYS--------------EIYRKAGKQFSSVIESEYVDVTSCIRDDE----LCESCKKYEM 218

  Fly   410 ---SQGMERSERVGNSTVA-------LLVRHRPGQAYITPNKPVVHVGNGVTLTCSANP------ 458
               ||.:...:....:.|:       :.:|.....|.|..|...||:....|..|.|..
Worm   219 GRLSQILAEDQEKPENKVSPVRPNLDITLRAADKVALIMSNCSYVHLPELRTPHCDAQTLADALQ 283

  Fly   459 ---------PGWPVPQYRWFRDMDGEFSSTQKILAQGPQYSIPKAHLGNEGKYHCHAVNELGIGM 514
                     ....:.:.|:|      ....||::..|..........|.|....|:.   ||:..
Worm   284 KMNYKTVTLADLTLDEMRYF------IRVYQKLIGNGVYAVFYFVGHGFEVNGQCYL---LGVDA 339

  Fly   515 MATIVLEIHQPPQFLAKLQQHMTRRVADTDYTVTCSAKGKPAPSVKWLKDAVEIL----PEENLY 575
            .|    :.|||        ||                    :.|:.||   :.|.    |:.||.
Worm   340 PA----DAHQP--------QH--------------------SMSMDWL---LSIFRHKTPDLNLL 369

  Fly   576 EVQT----NPDQGLNGMVTVQSQLKFRGKARPN---GNALVPGDRGLYTCLYQNEVNSA-----N 628
            .:..    .|...::..|....|.|...:|..|   |.: ..|..|.|.  .:.|||..     .
Worm   370 LLDVCRKFVPYDAISAFVEYSEQFKKFHRAHRNMVYGYS-TSGGVGAYE--VKGEVNGVFMKYLK 431

  Fly   629 SSMQLRIEHEPIVLHQYNKVAFDIRETAEVVCKVQAYPKPEFQ---------------------- 671
            :.:||.|.    |:...|||..||.:. :.||.:|.   ||.:
Worm   432 NHVQLEIS----VIDMLNKVLLDIGDD-QKVCDLQV---PEIRSTLTHPRSLADPLIFDGHTASF 488

  Fly   672 ------WQFGNN-PSPLTMSSDGHYEISTT--------TDNNDIYTSV----------------- 704
                  |:..:. |:|.|:..:....::|.        |:...::.|:
Worm   489 DNHTIHWRLMHELPTPATIRFETQQLVATIWFQFCGNFTNKVYVFASISDFRPCQEDTDMGENEE 553

  Fly   705 LKINSLTH------------SDYGEYT--------CRVANTLDTIR------APIRLQQKGPPEK 743
            |..|:|.|            ||..||.        ..:.:.|..|:      ..:.|:....|||
Worm   554 LSENALNHRAFVEFPEELHCSDVREYNDDEEGVSMLWILSGLQKIKKEAGLTCEVHLRHVDDPEK 618

  Fly   744 PTNLRATEVGH 754
            ...::..::||
Worm   619 TIEMKNVDIGH 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845
		I-set	146..249	CDD:254352	17/72 (24%)
		Ig	168..249	CDD:299845	17/72 (24%)
		IGc2	268..323	CDD:197706	19/60 (32%)
		Ig_3	341..406	CDD:290638	10/67 (15%)
		Ig_2	437..514	CDD:290606	17/91 (19%)
		I-set	526..633	CDD:254352	22/122 (18%)
		Ig	546..632	CDD:143165	20/101 (20%)
		IG_like	654..736	CDD:214653	22/161 (14%)
		Ig	656..734	CDD:143165	22/157 (14%)
		FN3	741..848	CDD:238020	5/14 (36%)
malt-1	NP_495424.2	Ig	122..182	CDD:299845	21/104 (20%)
malt-1	NP_495424.2	Peptidase_C14	252..481	CDD:279049	58/283 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7699
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950