Protein Alignment ed and LOC1281351

DIOPT Version :10

• Sequence 1: NP_523469.2
• Gene: ed / 33619
• FlyBaseID: FBgn0000547
• Length: 1332
• Species: Drosophila melanogaster
• Sequence 2: XP_061499696.1
• Gene: LOC1281351 / 1281351
• VectorBaseID: AGAMI1_001755
• Length: 1092
• Species: Anopheles gambiae
• Alignment Length: 1257
• Identity: 247/1257 - (19%)
• Similarity: 418/1257 - (33%)
• Gaps: 397/1257 - (31%)

  Fly   131 KGTGADVHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTC---SSIGGSPDPTITWY----- 187
            :||.:....|:.|    ||.|        ::.|.:....:|.|   |.|.|.....:.||
Mosquito    49 EGTSSGKDGEYEN----TPLH--------LSEAVQGTVGQLECNITSPISGDRAILVIWYKGAQT 101

  Fly   188 -----------REGSNTPLPATVLKGGTKDQP--TNATLSIIPRREDDGAKYKCVVR-NRAMNEG 238
                       ||||:....:: ..|.|...|  |.|.|.|:..:..|...|:|.|. :::....
Mosquito   102 IPFYTFDARDVREGSHRSSNSS-FDGRTNFYPNRTPAMLEILQTKPTDSGIYRCRVDFHKSPTRN 165

  Fly   239 KRLEATATL-------------NVNYYPRVEVGPENPLRVERDRTAKLECNVDAKPKVPNVRWNR 290
            .|::.|..:             ::.:|   .:||.|     ...|..:.|.......:|.|:|..
Mosquito   166 TRVQLTVIVPPEKLLIVDEKGSHIRHY---ILGPYN-----EGATINITCISTGGRPLPKVQWWY 222

  Fly   291 NGRFISSS-------------LVHTIHRVSVQDAGKYTCIA-DNGLGKTGEQELILDI-LYPPMV 340
            ..:.|:::             ::|.:.|..::..  :||.| :|.:.......:.||: |.|..|
Mosquito   223 ENKVINNTSVVLSDKRVKNTLVLHRLERKHLKSV--FTCQASNNNVTNPISASITLDMNLRPLSV 285

  Fly   341 VIESKTREAEEGDTVTIRCNVT-ANPAPVTIEWLKENSPDFRYNGDVLTLTSVRADHAGNYICRA 404
            .::.|.|......|..::|.|. :.||| ||.|.|.:             |.:|..|
Mosquito   286 RLQGKNRPLSANHTYDLQCEVLGSRPAP-TITWWKGS-------------TQMRGHH-------- 328

  Fly   405 VNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTCSANPPGWPVPQYRWF 469
                     |.::..||.||::|                                     .:|..
Mosquito   329 ---------ETTDPDGNVTVSIL-------------------------------------SFRPT 347

  Fly   470 RDMDGEFSSTQKILAQGPQYSIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQ 534
            .|..|::.|.:..:|     .||.|  |.|..:      :|.|..:..:.||......:.:.:.:
Mosquito   348 IDDKGKYLSCRAEMA-----VIPDA--GKEDGW------KLDIYHVPVVTLEYGTNYNYTSSIPE 399

  Fly   535 HMTRRVADTDYTVTCSAKGKPAPSVKWLKDAVEILPEENLYEVQTNPDQGLNGMVTVQSQ-LKFR 598
                   ..|....|:.|..|     |:   .:::......|:..||.:|    |||.:| |..:
Mosquito   400 -------GVDVYFECNIKSNP-----WV---YKVIWRHYGKELVNNPSEG----VTVSNQSLVLQ 445

  Fly   599 GKARPNGNALVPGDRGLYTCLYQN-EVNSANSSMQLRIEHEPI----VLHQYNKVAFDIRETAEV 658
            ..:|...        |.|||:..| |.:..::.:.|.|:..|:    ::..||   ....|.|::
Mosquito   446 NVSRNRA--------GQYTCVGSNREGDGESNPVHLDIKFAPVCRPGLVTTYN---VGRNELAKI 499

  Fly   659 VCKVQAYP-KPEFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRV 722
            ||:::|.| ...|.|::..:.|.       ..:|..:...:|...||.....:|..|||...|..
Mosquito   500 VCELEANPSNVTFTWKYNTSVSE-------SLDIPASEVLSDRTKSVAHFKPVTEKDYGTLLCWG 557

  Fly   723 ANTLDTIRAP--IRLQQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGLSKT---KFFVSYRRVA 782
            .|.:.....|  ..|...|.|:..:|........:.:.:....|:||||.:.   :.:|...|..
Mosquito   558 RNEIGAQTEPCLFNLIPAGKPDPLSNCTILNQTFDMLQIECLEGYDGGLPQVFQIELYVIGSRQQ 622

  Fly   783 MPREEQLIPDCATLANSNSAWVEVDCQRDIPCKVTALEQHQSYAFKVKALNPK--SDSPYSSEIM 845
            |          .::.:::.|:           .:..||....|...:.|.|.|  ||..|.....
Mosquito   623 M----------TSIKSTSPAF-----------DLKGLEPGVGYNIILTAKNSKGSSDPTYLQAFT 666

  Fly   846 V-----TTKVSRIPPPLQVTYEPNTRTLGIDVGATCLNLVAVVESMVNADSPMAAWEVVTTMDNL 905
            :     .|.:|.:.||..:..:|...||        |.:||.:.|:.:         ::..:..|
Mosquito   667 LKNPEKQTDLSLVYPPALLQIKPFIGTL--------LGVVAAIISIAS---------IIVCVTRL 714

  Fly   906 QLSGNGPTHKEKIIDRIIGARRVGGGRALGHTISEDEDDNGLN------SLALED--------EN 956
            :.|                   .|..|..|..:|.: |.:|::      .||.|.        |.
Mosquito   715 RGS-------------------AGRDRDCGSNMSTN-DASGISQSIPDADLAREQCNGSIDSIEK 759

  Fly   957 SPTV--RVKLC-LRTNPEHCGDYTDAEIGRPYIAEANALATPTLIAIIVSCVVFALFAGLILMFC 1018
            :|.:  :.||. |....|...::            .|..|.|.|.|  .:.:......||:
Mosquito   760 NPDIIPQAKLLHLLKEDEKAFEW------------LNNAAHPRLYA--TAAMAEQQSGGLL---- 806

  Fly  1019 RCKRNQSKKSAAAKDYEMDSVRPSIVAAQQNQAPPPYYPASGLDNKALEHSMDLALSMEDQKTAL 1083
                   ..||||..|:..:.......|||.|                :.......:...|....
Mosquito   807 -------PPSAAAATYDTRAFYALARDAQQQQ----------------QQQQQQQQNCMQQNVYP 848

  Fly  1084 YATQNGYSYHPGSGVV-------GVGMGGGVVGVGVGGSVVSGMGGGVGGI-----GGSGVGVNG 1136
            .|:.:|.||.|..|.:       |.|..|....:......:||.|||.||:     |...:.|:.
Mosquito   849 VASSDGQSYIPMHGTIISTPIVGGYGSDGHKHDLTYADLSISGGGGGAGGMPKLNPGQPQMYVSA 913

  Fly  1137 IPG-------------------LSAHTMPGNEWVNMGYM---ENNYSNSNNGGSVNSQDSLWQVK 1179
            ..|                   |:.|  ||....|:.|.   .::...|:..|          :.
Mosquito   914 TLGRPRQSDIKRSEPTIYAQIDLAHH--PGVHSTNLVYTNAPRHSIPISHATG----------LP 966

  Fly  1180 MSAAAVGNQQGMVQAPMNQYVEQQPAYGYDPLTHGGYGAVDDYAPYPHLTATPSQVGDEYHNLRN 1244
            :|.|.:..||.....|:...:::.|..|...||       :.|.|.|               |..
Mosquito   967 VSGAHLLQQQQQHTVPVQSPLQRAPDSGQPSLT-------ERYPPPP---------------LFG 1009

  Fly  1245 SQNP-SRQDYC-SDPYASVQKP 1264
            ...| |.|.:| ::|:.::..|
Mosquito  1010 GSLPVSGQQHCANEPFFTIPPP 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_523469.2	V-set	50..147	CDD:462230	4/15 (27%)
		Ig	153..249	CDD:472250	25/130 (19%)
		Ig strand B	169..173	CDD:409353	1/3 (33%)
		Ig strand C	183..187	CDD:409353	0/3 (0%)
		Ig strand E	211..215	CDD:409353	2/3 (67%)
		Ig strand F	225..230	CDD:409353	2/4 (50%)
		Ig strand G	242..245	CDD:409353	0/2 (0%)
		Ig_3	253..320	CDD:464046	14/80 (18%)
		Ig_3	337..406	CDD:464046	17/69 (25%)
		Ig_2	437..>504	CDD:464026	10/66 (15%)
		Ig	525..635	CDD:472250	22/111 (20%)
		Ig strand B	545..549	CDD:409568	0/3 (0%)
		Ig strand C	558..562	CDD:409568	0/3 (0%)
		Ig strand E	587..591	CDD:409568	1/3 (33%)
		Ig strand F	615..620	CDD:409568	3/4 (75%)
		Ig strand G	628..631	CDD:409568	0/2 (0%)
		Ig_3	639..724	CDD:464046	21/89 (24%)
		FN3	741..848	CDD:238020	20/116 (17%)
LOC1281351	XP_061499696.1	None