Protein Alignment ed and LOC1279738

DIOPT Version :10

• Sequence 1: NP_523469.2
• Gene: ed / 33619
• FlyBaseID: FBgn0000547
• Length: 1332
• Species: Drosophila melanogaster
• Sequence 2: XP_061499495.1
• Gene: LOC1279738 / 1279738
• VectorBaseID: AGAMI1_008877
• Length: 1393
• Species: Anopheles gambiae
• Alignment Length: 1326
• Identity: 260/1326 - (19%)
• Similarity: 416/1326 - (31%)
• Gaps: 417/1326 - (31%)

  Fly    17 SARRAATTICNFFLIALVALSSTTLADESIDTRENAD---------------LTLKCRFNDKYEA 66
            :|.|:.|     ..:.||.|::  ||...||..|:.|               .||.|....: |.
Mosquito     4 AAARSIT-----LAVTLVMLAN--LARAQIDWAEDDDDPVSTVTVEAVLGRTATLPCDIEPE-EL 60

  Fly    67 ND--FSFFWTRWTANP---------AQFDNVAIGEVQLSSGYRLDFQPERGIYDLQIKNVSYNRD 120
            ||  :...|.|.:|..         .||..........:.|.|..|........|.:.|:..: |
Mosquito    61 NDRVYMVLWFRESAGKPLYSYDVRGRQFSKALYWSETSAFGPRAYFVTISKPAALSVDNIQLD-D 124

  Fly   121 NGRFECRIKAKGTGADVHQEFHNLTVLTPPHPPVI-------SPGNIAVATEDKPMELTCSSIGG 178
            .|.:.||:..:.:....|:  .||||..|||..::       ..|.|....||..:.|||...||
Mosquito   125 EGVYRCRVDFQNSPTRNHR--INLTVTVPPHQILVYDASGLDVTGAIGPLQEDDNLVLTCEVRGG 187

  Fly   179 SPDPTITWYREGSNTPLPATVLKGGTKDQPTNATLSI----------IPR--REDDGAKYKCVVR 231
            .|:||:||.              .|.:...|...:|:          ||:  |......|||...
Mosquito   188 RPEPTVTWL--------------NGDEIMQTGGGISMGRHVTVNRLEIPKMTRSALNNTYKCQAS 238

  Fly   232 NRAMNEGKRLEATATLNVNYYPRVEVGPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFIS 296
            |..:  ....|.:..:::...|........|.::..::...|.|||.......:::|.:|.|..:
Mosquito   239 NTKL--VPPAERSIRVDMLLKPLSASLSSKPKQLISNQEYVLACNVAGSVPETDIKWMQNNRPFT 301

  Fly   297 SSLVHTIHRVSV------------QDAGKYTCIADNGLGKTG--EQELILDILYPPMVVIESKTR 347
            ...:..|:..|:            .|.....|...|...:..  |..:|:::||||.|.:...:.
Mosquito   302 KGKIKLINNSSMVSSVLSFRPHPDDDGTILKCEGSNPRLQNSVLEDSVIMNVLYPPQVTLSLGST 366

  Fly   348 ----EAEEGDTVTIRCNVTANPAPVTIEWLKENSPDFR--YNGDV-----LTLTSVRADHAGNYI 401
                :.:|||.|...|::.|||....|.|..:..|..:  .:|.:     |.|..|...|:|:|.
Mosquito   367 LNPDDIKEGDDVYFECHIKANPREHRITWSHDGLPVTQNVTSGVIISTRSLVLQRVGRFHSGSYA 431

  Fly   402 CRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTCSANPPGWPVP-- 464
            |.|.|       :|.| ..:..|||.:...|           |.:.|.:.:..::.....|||
Mosquito   432 CAAAN-------DRGE-TQSDPVALKIHFAP-----------VCISNSIMIVGASLDETVPVPCH 477

  Fly   465 --------QYRW--------FRDMDGEFSSTQKILAQGPQYSIPKAHLGNEGKYHCHAVNELGIG 513
                    .:.|        |....|:|:..|:...:|.          .:.:|.....|
Mosquito   478 VAADPLDVSFDWNFSNSGERFEVASGQFNLLQEFHPEGI----------TQSRYDADEDN----- 527

  Fly   514 MMATIVLEIHQPPQFLAKLQQHMTRRVADTDY-TVTCSAKGKPAPSVKWLKDAVEILPEENLYEV 577
              :..:.|:...|:             ::.:| |:.|           |.|:::....|..|::|
Mosquito   528 --SETIYELLYTPK-------------SEREYGTLAC-----------WAKNSIGKQVEPCLFQV 566

  Fly   578 QTNPDQGLNGMVTVQSQLKFRG-KARPNGNALVPGDRGLYTCLYQNEVNSANSSMQLRIEHEPIV 641
                       |........|. ..||....:.|.          ...:|.|:|
Mosquito   567 -----------VPAAKPAPLRNCTLRPYSTLMSPA----------GPQHSQNAS----------- 599

  Fly   642 LHQYNKVAFDIRETAEVVCKVQAYPKPEFQWQFGNNPS--PLTMSSDGHYEISTTTDNNDIYTSV 704
                             .....||     .:.:|:.||  |.......||.     |.|.|....
Mosquito   600 -----------------AASASAY-----SYTYGDPPSSHPAGRHPGQHYR-----DTNYIVPQF 637

  Fly   705 LKINSLTHSDYGEYTCRVANTLDTIRAPIRLQQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGL 769
            :|..::..:|....|             ::..||.|.......|||  |.:..||..........
Mosquito   638 VKDRNVPPADQRNVT-------------VKFNQKNPNPGAAGSRAT--GPSTASLRSSSSSSSSF 687

  Fly   770 S--KTKFFVSYRRVAMPREEQLIPDCATLANSNSAWVEVDCQRDIPCKVTALEQHQSYA---FKV 829
            :  |....||.||....|....:|   ::.::::|            ::||....:|.|   .|.
Mosquito   688 AAVKASGAVSNRRDRRNRTGGGLP---SIRDTDTA------------RLTADGGEESSAGTGSKE 737

  Fly   830 KALNPKSDSPYSSEIMVTTKVSRIPPPLQVTYEPNTRTLGIDVGATCLNLVAVVESMVNADSPMA 894
            ...:|....|.....||..:| :..|....:.|.|:||       ..||....|.......:.:.
Mosquito   738 PLADPPRPLPAQPLEMVRRRV-KAAPGSTTSDEQNSRT-------ELLNTATAVLLGEGGSAAVL 794

  Fly   895 AWEVVTTMDNLQLSGNGPTHKEKIIDRIIGARRVGGGRALGHTIS------------EDEDDNGL 947
            |...|         ||.||.:::            |.|...:|::            :|:||...
Mosquito   795 ASSAV---------GNDPTEQQR------------GSRLRRYTMNSSTAHQRALFDDDDDDDEIF 838

  Fly   948 NSLALEDENSPTVRVKLCLRTNPEHCGDYTD--AEIGRPYIAEANALATPTLIAIIVSCVVFALF 1010
            ::.:|...||..........::.:|....:|  |..|..|....||.|...:
Mosquito   839 SNASLPAANSRGSESNSNQPSHLQHSSSSSDDRARGGNNYHTPGNAAAAAPI------------- 890

  Fly  1011 AGLILMFCRCKRNQSKKSAAAKDYEMDSVRPSIVAAQQNQAPPPYYPASGLDNKALEHSMDLALS 1075
                                                           ||.|.:|.:.|...||..
Mosquito   891 -----------------------------------------------ASQLRSKTIRHQSTLAPP 908

  Fly  1076 MEDQKTALYATQNGYSYHPG-SGVVGVG---MGGG--------VVGVGVGGSVVSGMGGGVGGIG 1128
            ......:|.:...|:|   | :|..|.|   .||.        .||.|.||      |||.||.|
Mosquito   909 APPSAASLASYGGGFS---GVNGATGHGPTSYGGNHHQHHQHHYVGPGDGG------GGGGGGTG 964

  Fly  1129 GSGVGVNGIPGLSAHTMPGNEWVNMGYMENNYSNSNNGG-----SVNSQDS-LWQVKMSAAAVGN 1187
            |.          |.....||| :....||.......:||     .:.:.|| ..:::::..:..|
Mosquito   965 GG----------SHSASVGNE-LQPTMMELECVAGYDGGLPQHFFLEAYDSRTRKLRLNITSALN 1018

  Fly  1188 QQGMVQAPMNQYVEQQPAYGYDPLTH 1213
            ...:.:..:   .|..|:..|.|..|
Mosquito  1019 DVPLFRIDL---TELSPSEAYTPTLH 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_523469.2	V-set	50..147	CDD:462230	26/122 (21%)
		Ig	153..249	CDD:472250	25/114 (22%)
		Ig strand B	169..173	CDD:409353	1/3 (33%)
		Ig strand C	183..187	CDD:409353	2/3 (67%)
		Ig strand E	211..215	CDD:409353	0/3 (0%)
		Ig strand F	225..230	CDD:409353	3/4 (75%)
		Ig strand G	242..245	CDD:409353	1/2 (50%)
		Ig_3	253..320	CDD:464046	13/78 (17%)
		Ig_3	337..406	CDD:464046	23/79 (29%)
		Ig_2	437..>504	CDD:464026	12/84 (14%)
		Ig	525..635	CDD:472250	17/111 (15%)
		Ig strand B	545..549	CDD:409568	2/4 (50%)
		Ig strand C	558..562	CDD:409568	0/3 (0%)
		Ig strand E	587..591	CDD:409568	1/3 (33%)
		Ig strand F	615..620	CDD:409568	0/4 (0%)
		Ig strand G	628..631	CDD:409568	1/2 (50%)
		Ig_3	639..724	CDD:464046	14/86 (16%)
		FN3	741..848	CDD:238020	23/111 (21%)
LOC1279738	XP_061499495.1	None