Protein Alignment ed and LOC1278969

DIOPT Version :10

• Sequence 1: NP_523469.2
• Gene: ed / 33619
• FlyBaseID: FBgn0000547
• Length: 1332
• Species: Drosophila melanogaster
• Sequence 2: XP_061512275.1
• Gene: LOC1278969 / 1278969
• VectorBaseID: AGAMI1_012658
• Length: 898
• Species: Anopheles gambiae
• Alignment Length: 1092
• Identity: 209/1092 - (19%)
• Similarity: 338/1092 - (30%)
• Gaps: 381/1092 - (34%)

  Fly    76 WTANPAQFDNVAIGEVQLSSGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKAKGTGADVHQE 140
            |:| |..|            |.|..|..::....|.|||:. ..|.|.:.|||..:......::
Mosquito    88 WSA-PEVF------------GSRAKFNIDKSPASLLIKNLK-RHDQGVYRCRIDFRTIQTQTYR- 137

  Fly   141 FHNLTVLTPPHPPVISP--GNIAVATEDKPME------LTCSSIGGSPDPTITW----------Y 187
             :||:|:..|..||:..  |.....|:..|.|      :||...||.|.|.:.|          |
Mosquito   138 -YNLSVIVLPEQPVVLDRWGRHLNGTKLGPKEEGDDVVITCRVSGGRPQPEVRWLINGVIVDDQY 201

  Fly   188 REGSNTPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYY 252
            .:.|.             |...|..|....:|.|..|.:.|...|..:.|.|  |.:..|:::..
Mosquito   202 EQNSG-------------DVIENRLLWPTIQRSDLNAIFTCQTMNTKLVEPK--ETSYVLDMHLK 251

  Fly   253 PRVEVGPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTI-HRV---------S 307
            |........|..:..|:..::.|..........:.|.:..|.:..:...|: |..         :
Mosquito   252 PLTIKVINPPATLVADKRYEIVCQSTGSRPNAIITWYKGKRQMRRTRDETVDHNTTTSTLSFAPT 316

  Fly   308 VQDAGK-YTCIAD----NGLGKTGEQELILDILYPPMVVIE----SKTREAEEGDTVTIRCNVTA 363
            .:|.|| .||.|:    |||..  |.:..::::|||||.|:    ....:.:|||.|...|:|.|
Mosquito   317 TEDDGKTLTCRAENPNVNGLFL--ETDWKMNVVYPPMVTIQLGPTLVVDDIKEGDDVYFECHVRA 379

  Fly   364 NPAPVTIEWLKENSPDFRYNGDVLTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLV 428
            ||....::|. .|....:|||                   :..|:||
Mosquito   380 NPDWKRLQWF-HNDVLLQYNG-------------------SARIIQS------------------ 406

  Fly   429 RHRPGQAYITPNKPVVHVGNGVTLTCSANPPGWPVPQYRWFRDMDGEFSSTQKILAQGPQYSIPK 493
                ||:.:                                         .||:..|
Mosquito   407 ----GQSLV-----------------------------------------LQKVTKQ-------- 418

  Fly   494 AHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTRRVADTDYTVTCSAKGKPAPS 558
                :.|.|.|.|:|..|    .|:            ..|||:  ||   .:...|:.:
Mosquito   419 ----SAGYYACSAINAEG----ETV------------SDQQHL--RV---KHVPVCATE------ 452

  Fly   559 VKWLKDAVEILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRGLYTCLYQNE 623
                                                       |..|||  ||..|       .:
Mosquito   453 -------------------------------------------RHGGNA--PGGNG-------TD 465

  Fly   624 VNSANSSMQLRIEHEPIVLHQYNKVAFDIRETAEVVCKVQAYPKP-EFQWQFGNNPSPLTMSSDG 687
            .:.:|.:..|              :.....|..|:.|.:.|.|.. .|.|:|.|:...|.:  |.
Mosquito   466 PSGSNRNAIL--------------IGASRNENVEIPCHIFADPPARSFHWRFNNSAEILPV--DA 514

  Fly   688 HYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIRAP--IRLQQKGPPEKPTNLRAT 750
            |   ..|:..|   .|:|....:|..|:|..||...|.:.....|  .:|.....|...:|....
Mosquito   515 H---RYTSQGN---ISILNYAPVTDQDFGTLTCWAVNEVGPQSQPCTFQLVLADLPSPVSNCSLP 573

  Fly   751 EVGHNYVSLSWDPGFDGGLSKTKFFV---SYRRVAMPREEQLIPDCATLANSNSAWVEVDCQRDI 812
            .....:..:...||:||||.:.  ||   ..:|....|        ...:|.|..:..:|....:
Mosquito   574 NRTQQFAEIQCTPGYDGGLPQV--FVLELVSKRTGTRR--------FNFSNKNEPFFVLDRLEKL 628

  Fly   813 PCKVTALEQHQSYAFKVKALNPKSDSPYSSEIMVTTKVSRIPPPLQVTYEPNTRTLGIDVGATCL 877
            ...:|.  ::.|.:..|.|:|.|..|  :..::...::.||.|     |.
Mosquito   629 SALMTL--ENNSLSCVVYAINQKGRS--TPVLIQDFEIGRIQP-----YR--------------- 669

  Fly   878 NLVAVVESMVNADS--PMAAWEVVTTMDNLQLSGNGPTHKEKIIDRIIGARRVGGGRALGHTISE 940
               ||.|...:|..  |:|. .::.|:..|.||.:..|:..:.:......||....       |.
Mosquito   670 ---AVTERRADAIEWLPIAV-GILLTVIILALSISTKTYLNRCLAAGCCCRRCCAA-------SA 723

  Fly   941 DEDDNGLNSLALEDENSPTVRVKLCLRTNPEHCGDYTDAEIGRPYIAEANALATPTLIAIIVSCV 1005
            ..:|...:..:.:.:.....:.|..|..:...||              |:.|....:..:
Mosquito   724 KRNDASASDKSEQQQQHQQQQTKNVLLPDEYECG--------------AHCLKLKNVQML----- 769

  Fly  1006 VFALFAGLILMFCRCKRNQSKKSAAAKDYEMDSVRPSIVAAQQNQ-------APPPYYPASGLDN 1063
                           :|:.|:|...:||...|...|.::.||.|.       |.|.:..|:..|.
Mosquito   770 ---------------RRHSSRKKNCSKDSNDDEPEPDVIPAQFNMVSCTPLIATPQHTDAAARDK 819

  Fly  1064 KALEHS--------------MDLALSMEDQKTALYATQNGYSYHPGSGVVGV 1101
            .|.::.              :|...::..|.|||       .|.....:||:
Mosquito   820 DAHQYGGFTSPPATYKMGTIVDHHPAVPQQDTAL-------EYRTHGSIVGI 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_523469.2	V-set	50..147	CDD:462230	18/70 (26%)
		Ig	153..249	CDD:472250	27/113 (24%)
		Ig strand B	169..173	CDD:409353	1/9 (11%)
		Ig strand C	183..187	CDD:409353	1/13 (8%)
		Ig strand E	211..215	CDD:409353	1/3 (33%)
		Ig strand F	225..230	CDD:409353	1/4 (25%)
		Ig strand G	242..245	CDD:409353	1/2 (50%)
		Ig_3	253..320	CDD:464046	14/81 (17%)
		Ig_3	337..406	CDD:464046	19/72 (26%)
		Ig_2	437..>504	CDD:464026	5/66 (8%)
		Ig	525..635	CDD:472250	15/109 (14%)
		Ig strand B	545..549	CDD:409568	0/3 (0%)
		Ig strand C	558..562	CDD:409568	0/3 (0%)
		Ig strand E	587..591	CDD:409568	0/3 (0%)
		Ig strand F	615..620	CDD:409568	0/4 (0%)
		Ig strand G	628..631	CDD:409568	1/2 (50%)
		Ig_3	639..724	CDD:464046	21/85 (25%)
		FN3	741..848	CDD:238020	22/109 (20%)
LOC1278969	XP_061512275.1	None