DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and Cd22

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_006539552.1	Gene:	Cd22 / 12483	MGIID:	88322	Length:	879	Species:	Mus musculus

Alignment Length:	922	Identity:	207/922 - (22%)
Similarity:	323/922 - (35%)	Gaps:	252/922 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ENADLTLKCRFNDKYEANDFSFFWTRWTANP-AQFDNVAI--------------GEVQLSSGYRL 99
            |.|.:.:.|::.               |..| |:.||:.:              |.| |.:..:.
Mouse    49 EGACIRIPCKYK---------------TPLPKARLDNILLFQNYEFDKATKKFTGTV-LYNATKT 97

  Fly   100 DFQPERGIY-----------------DLQIKNVSYNRDNGRFECRIKAKGTGADVHQEFHNLTVL 147
            :..||..:|                 .|:|..:..| |:|....|:.|   |.:...|..:|.|.
Mouse    98 EKDPESELYLSKQGRVTFLGNRIDNCTLKIHPIRAN-DSGNLGLRMTA---GTERWMEPIHLNVS 158

  Fly   148 TPPHPPVIS-PGNIAVATEDKPMELTC----SSIGGSPDPTITWYREGSN-TPLPATV------L 200
            ..|..|.|. |..|   .|.:.:.|||    |..|  .|..:.|:.|.|. |.:.::|      :
Mouse   159 EKPFQPYIQMPSEI---RESQSVTLTCGLNFSCFG--YDILLKWFLEDSEITSITSSVTSITSSV 218

  Fly   201 KGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRL-EATATLNVNYYPRVEVGPENPLR 264
            ....|:..|.:.|:..|:..|.|...||.|:    :..|.| |.|..|:|.|.|::|: ..||..
Mouse   219 TSSIKNVYTESKLTFQPKWTDHGKSVKCQVQ----HSSKVLSERTVRLDVKYTPKLEI-KVNPTE 278

  Fly   265 VERDRTAKLECNVD-AKPKVPN--VRWNRNGRFIS----------SSLVHTIHRVSVQDAGKYTC 316
            ||::.:..:.|.|: :.||:..  |.|.::||.:.          |.|:  :|.|:....|||.|
Mouse   279 VEKNNSVTMTCRVNSSNPKLRTVAVSWFKDGRPLEDQELEQEQQMSKLI--LHSVTKDMRGKYRC 341

  Fly   317 IADNGLGKTGEQELILDILYPPMVV-IESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSPDF 380
            .|.|.:|....:|:.|.:.|.|... :......||||.:|.:.|...|:|:.....|.....|
Mouse   342 QASNDIGPGESEEVELTVHYAPEPSRVHIYPSPAEEGQSVELICESLASPSATNYTWYHNRKP-- 404

  Fly   381 RYNGDV---LTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTV---ALLVRHRPGQAYITP 439
             ..||.   |.:..|...|||||.|.|.|           |:|:..:   |.|..|...:|..|.
Mouse   405 -IPGDTQEKLRIPKVSPWHAGNYSCLAEN-----------RLGHGKIDQEAKLDVHYAPKAVTTV 457

  Fly   440 NK---PVVHVGNGVTLTCSANPPGWPVPQYRWFRDMDGEFSSTQKILAQGPQY-SIPKAHLGNEG 500
            .:   |::. |:.|||.|..|.....|..|||.....|.......:..|...: |:|.:
Mouse   458 IQSFTPILE-GDSVTLVCRYNSSNPDVTSYRWNPQGSGSVLKPGVLRIQKVTWDSMPVS------ 515

  Fly   501 KYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTRRV-ADTDYTVTCS-AKGKPAPSVK--W 561
               |.|.|. .......::|.:|..|:.:..|:......: |.....:.|. |:..|| .|:  |
Mouse   516 ---CAACNH-KCSWALPVILNVHYAPRDVKVLKVSPASEIRAGQRVLLQCDFAESNPA-EVRFFW 575

  Fly   562 LKDAVEILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRGLYTCLYQNEV-N 625
            .|:.  .|.:|..|                   |.|        .::.|.|.|.|.|:..|.: .
Mouse   576 KKNG--SLVQEGRY-------------------LSF--------GSVSPEDSGNYNCMVNNSIGE 611

  Fly   626 SANSSMQLRIEHEPIVLHQYNKVAFDIRE--TAEVVCKVQAYPK-PEFQWQFGNNPSPLTMSSDG 687
            :.:.:..|::.:.|..|.........:.|  .|.:.|:..|.|. .::.|          ..|.|
Mouse   612 TLSQAWNLQVLYAPRRLRVSISPGDHVMEGKKATLSCESDANPPISQYTW----------FDSSG 666

  Fly   688 HYEISTTTDNNDIYTS--VLKINSLTHSDYGEYTCRVANTLDTIRAPIRLQQKGPPEKPTNLRAT 750
                      .|:::|  .|::..|.....|.|.|:..|.:.|        .:.||...|...:.
Mouse   667 ----------QDLHSSGQKLRLEPLEVQHTGSYRCKGTNGIGT--------GESPPSTLTVYYSP 713

  Fly   751 EVGHNYVSL--------------------SW-----DPGFDGGLSKTKFFV---SYRRVAMPREE 787
            |.....|:|                    .|     ..|.....|...|||   ..||..:....
Mouse   714 ETIGKRVALGLGFCLTICILAIWGMKIQKKWKQNRSQQGLQENSSGQSFFVRNKKARRTPLSEGP 778

  Fly   788 QLIPDCATLANSNSAWVEVDCQRDIPCKVTALEQHQSYAFKVKALNPKSDSPYSSEIMVTTKVSR 852
            |                      ...|...|::...|||.   ...|:||:..:.:  ..|..::
Mouse   779 Q----------------------SQGCYNPAMDDTVSYAI---LRFPESDTHNTGD--AGTPATQ 816

  Fly   853 IPPPL---QVTY 861
            .|||.   .|||
Mouse   817 APPPNNSDSVTY 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	24/128 (19%)
		I-set	146..249	CDD:254352	32/115 (28%)
		Ig	168..249	CDD:299845	25/92 (27%)
		IGc2	268..323	CDD:197706	18/67 (27%)
		Ig_3	341..406	CDD:290638	21/68 (31%)
		Ig_2	437..514	CDD:290606	19/80 (24%)
		I-set	526..633	CDD:254352	21/111 (19%)
		Ig	546..632	CDD:143165	18/89 (20%)
		IG_like	654..736	CDD:214653	17/86 (20%)
		Ig	656..734	CDD:143165	16/80 (20%)
		FN3	741..848	CDD:238020	22/134 (16%)
Cd22	XP_006539552.1	Ig	37..145	CDD:386229	21/115 (18%)
		Ig	164..250	CDD:386229	25/94 (27%)
		Ig_3	271..345	CDD:372822	22/76 (29%)
		IGc2	377..435	CDD:197706	21/71 (30%)
		IGc2	554..610	CDD:197706	18/85 (21%)
		Ig_3	629..695	CDD:372822	15/85 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010