DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and LOC110439987

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_021333826.1	Gene:	LOC110439987 / 110439987	-ID:	-	Length:	725	Species:	Danio rerio

Alignment Length:	777	Identity:	176/777 - (22%)
Similarity:	290/777 - (37%)	Gaps:	175/777 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RAATTICNFFLIALVALSS----TTLADESIDTRENADLTLKCRFNDKYEANDFSF---FWTR-W 76
            |.|..:...||:.:..:|:    ...:...|...:|:.:|:.|.|.  |....:..   ||.: .
Zfish     6 RMAPALHLIFLLIIHRVSAAGWGVNYSPSQICALQNSSVTISCTFT--YPTTGYQIMKVFWNKDL 68

  Fly    77 TANPAQFDNVA-----------IGEVQLSSGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKA 130
            ..|..:|.:::           :|:.:.:...||             .:|:.| |...:..||..
Zfish    69 VKNGGEFADLSEDPEYSQRLQYLGDKKQNCTIRL-------------SHVTKN-DEHEYYFRITT 119

  Fly   131 KGTGA------DVHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTCS-SIGGSPDPTITWYR 188
            ..||.      .||....:|.:.:|..           .||...:.|||. |...:..||..|||
Zfish   120 NVTGGRIIGIPGVHLNVTDLQLESPER-----------VTEGDSVRLTCKRSCNLTDTPTFIWYR 173

  Fly   189 EGSNTPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYP 253
            .       :.:|..||    |...|.:.|.|.:|..:|:|.|....:     ......|||.|.|
Zfish   174 N-------SEILTTGT----TGDKLILDPVRGEDAGRYRCAVLGNTL-----ASPDVYLNVTYPP 222

  Fly   254 -RVEVGPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYTCI 317
             .|.|.......:.:..:..|.|:.::.|...|..|.:....:.|..:..|.::|..|:|:|.|.
Zfish   223 NNVSVSINGSAVIVKGDSVSLICSSNSNPPALNFSWFKGETSVGSGRIFNISKISSDDSGEYKCR 287

  Fly   318 ADNGLGKTGEQELILDILYPPMVVIESKTREA--EEGDTVTIRCNVTANPAPVTIEWLKENSPDF 380
            |.|.||:.....:.||:.|||..|..|..|.|  ..||:||:.|:..:|| |....|.|..:  :
Zfish   288 ARNDLGEKYSAPVTLDVQYPPRNVSISIRRSAVIMSGDSVTLNCSSDSNP-PALFSWFKGTT--Y 349

  Fly   381 RYNGDVLTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKP-VV 444
            ..:|.:..:.::.:|.:|.|.|:|.|   ..|::.|:     .|.|..::.|....::.:.| |:
Zfish   350 VGSGRIFNILNISSDDSGEYKCKAKN---EHGVKYSD-----PVTLDAQYPPRNISVSISGPAVI 406

  Fly   445 HVGNGVTLTCS--ANPPGWPVPQYRWFRDMDGEFSSTQKILAQGPQYSIPKAHLGNEGKYHCHAV 507
            ..|:.|||:||  :|||..   .:.||:   |:.|     :..|..:||.|....:.|:|.|.|.
Zfish   407 MSGDSVTLSCSSDSNPPAL---NFSWFK---GDTS-----VGSGRIFSISKISSDDSGEYKCRAK 460

  Fly   508 NELGIGMMATIVLEIHQPPQFLAKLQQHMTRRVADTDYTVTCSAKGKPAPSVKWLKDAVEILPEE 572
            |:.|......:.|::...|:.::.........::....|:.||:...|...:.|.|...
Zfish   461 NDHGEKYSDPVTLDVQYAPRNISVSISGSAVIMSGDSVTLNCSSDSNPPAEINWFKGET------ 519

  Fly   573 NLYEVQTNPDQGLNGMVTVQSQLKFRGKARP-NGNALVPGDRGLYTCLYQNEVNSANSSMQLRIE 636
                                    |.|..|. |.:.:...|.|.|.|..:||.....|
Zfish   520 ------------------------FVGSGRIFNISKISSDDSGEYKCRARNEHGEEYS------- 553

  Fly   637 HEPIVLHQYNKVAFDIRETAEVVCKVQAYPKPEFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIY 701
             :|:              |.:|....|..|..|..|..|.     |....|.:
Zfish   554 -DPV--------------TLDVQSVTQTLPPAEISWFKGE-----TSVGSGRF------------ 586

  Fly   702 TSVLKINSLTHSDYGEYTCRVANTL-DTIRAPIRLQQKGPPEKPTNLRATEVGHNYVSLSWD 762
               ..|:.::..|.|||.||..|.. :....|:.|..:.||.   |: :..|..::|.:|.|
Zfish   587 ---FNISKISSDDSGEYKCRARNAHGEKYSDPVTLDVQYPPR---NI-SVSVSGSHVVMSGD 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	22/117 (19%)
		I-set	146..249	CDD:254352	24/103 (23%)
		Ig	168..249	CDD:299845	21/81 (26%)
		IGc2	268..323	CDD:197706	14/54 (26%)
		Ig_3	341..406	CDD:290638	20/66 (30%)
		Ig_2	437..514	CDD:290606	25/79 (32%)
		I-set	526..633	CDD:254352	18/107 (17%)
		Ig	546..632	CDD:143165	17/86 (20%)
		IG_like	654..736	CDD:214653	18/82 (22%)
		Ig	656..734	CDD:143165	17/78 (22%)
		FN3	741..848	CDD:238020	6/22 (27%)
LOC110439987	XP_021333826.1	V-set	31..137	CDD:311561	22/121 (18%)
		IGc2	149..202	CDD:197706	19/63 (30%)
		Ig_2	232..304	CDD:316418	17/71 (24%)
		Ig_2	318..387	CDD:316418	21/79 (27%)
		Ig_2	403..475	CDD:316418	26/82 (32%)
		Ig_2	489..560	CDD:316418	19/122 (16%)
		Ig_2	<568..620	CDD:316418	16/71 (23%)
		Ig_2	640..705	CDD:316418	1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010