DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ed and MALT1

DIOPT Version :9

Sequence 1:NP_001260013.1 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster
Sequence 2:NP_006776.1 Gene:MALT1 / 10892 HGNCID:6819 Length:824 Species:Homo sapiens


Alignment Length:764 Identity:144/764 - (18%)
Similarity:233/764 - (30%) Gaps:265/764 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   327 EQELILDILYPP--MVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYNGDVLTL 389
            |...:|.:|.||  .:.:..:::....|..|.:.|..|.:|. |..:|.|.|......|...|..
Human   114 EHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPF-VQYQWFKMNKEIPNGNTSELIF 177

  Fly   390 TSVRADHAGNYICRAVNIMQ--------------SQGMERS-ERVGNSTVALLVRHRPGQAYITP 439
            .:|....||.|:||..|...              .:..:|| :.|..|.:         |..:.|
Human   178 NAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKL---------QICVEP 233

  Fly   440 NKPVVHVGNGVTLTCSANPPGWPVPQYRWFRDMDGEFSSTQKILAQGPQYSIPKAHLGNEGKYHC 504
            ....:..|:.:.|.|.|  .|.|:|.|:||::.......|:|:      |.:|...|.::|.|.|
Human   234 TSQKLMPGSTLVLQCVA--VGSPIPHYQWFKNELPLTHETKKL------YMVPYVDLEHQGTYWC 290

  Fly   505 HAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTRRVADTDYTVTCSAK-----GKP-----APSV 559
            |..|:              :..|...|::..:.|    ||..|.|:..     |.|     ....
Human   291 HVYND--------------RDSQDSKKVEIIIGR----TDEAVECTEDELNNLGHPDNKEQTTDQ 337

  Fly   560 KWLKDAVEIL--------------PEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVP 610
            ...||.|.:|              |..::||: ||..:.|:..|.....|............|:.
Human   338 PLAKDKVALLIGNMNYREHPKLKAPLVDVYEL-TNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLL 401

  Fly   611 GDRGLYTCLYQNEVNSANSSMQLRIEHEPIVLHQYNKVAFDIRETAEVVCKVQAYPKPEFQWQFG 675
            .|:|:|..||                   ...|.|.                          .||
Human   402 LDKGVYGLLY-------------------YAGHGYE--------------------------NFG 421

  Fly   676 NN-------PSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDYGEY---TCRVANTL-DTI 729
            |:       |:|.            .::|.....::||:.....:....:   .||..|.. |||
Human   422 NSFMVPVDAPNPY------------RSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTI 474

  Fly   730 RAPIRLQQKGPPEKPTNLRATEVGHN----YVSLSWDPGFD---GGLSKTKF--FVSYRRVAMPR 785
              ||             |.|.:|..|    |.:......|:   .||:...|  |:..|.:...:
Human   475 --PI-------------LDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKK 524

  Fly   786 EEQLIPDCATLANSNSAWVEVDCQRDI-PCKVT----ALEQHQSYAFKVKALNPKSDSPYSSEIM 845
            ...|:.:.|               .|: .|.:|    |||...|.:.|....:|...:.||:|.:
Human   525 ITVLLDEVA---------------EDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESL 574

  Fly   846 VT----TKVSRIPPPLQVTYEPNTRTLGIDVGATCLNLVAVVESMVNADSPMAAWEVVTTMDNLQ 906
            |.    .|...:|..:.:.::...: :.:...|...|::.:..|:|.....:...:...|...|.
Human   575 VRNLQWAKAHELPESMCLKFDCGVQ-IQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLD 638

  Fly   907 LSGNGPTHKEKIIDRIIGARRVGGGRALGHTISEDEDDNGLNSLALEDENSPTVRVKLCLRTNPE 971
            |                                 |.|....|....|:..|..|...|     |:
Human   639 L---------------------------------DIDPKDANKGTPEETGSYLVSKDL-----PK 665

  Fly   972 HC--------------------------------GDYTDAEIGRPYIAE 988
            ||                                .|..:..:|:|.||:
Human   666 HCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAK 714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
edNP_001260013.1 Ig 50..147 CDD:299845
I-set 146..249 CDD:254352
Ig 168..249 CDD:299845
IGc2 268..323 CDD:197706
Ig_3 341..406 CDD:290638 17/64 (27%)
Ig_2 437..514 CDD:290606 21/76 (28%)
I-set 526..633 CDD:254352 27/130 (21%)
Ig 546..632 CDD:143165 22/109 (20%)
IG_like 654..736 CDD:214653 16/92 (17%)
Ig 656..734 CDD:143165 15/88 (17%)
FN3 741..848 CDD:238020 26/124 (21%)
MALT1NP_006776.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Death_MALT1 42..126 CDD:260053 4/11 (36%)
Ig_2 128..194 CDD:290606 17/66 (26%)
IG_like 133..201 CDD:214653 18/68 (26%)
Ig_2 232..308 CDD:290606 23/97 (24%)
I-set 233..308 CDD:254352 23/96 (24%)
Peptidase_C14 343..560 CDD:279049 55/304 (18%)
Caspase-like 348..562 53/301 (18%)
Nuclear export signal 369..376 2/7 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7699
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.950

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