DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ed and LOC108183407

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_021330937.1	Gene:	LOC108183407 / 108183407	-ID:	-	Length:	495	Species:	Danio rerio

Alignment Length:	472	Identity:	92/472 - (19%)
Similarity:	148/472 - (31%)	Gaps:	187/472 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CNFFLIALVALSSTTLADESIDTRENADLTLKCRF--NDKYEAN---DFSFFWTRWTANPAQFDN 85
            |..|.|:|         .|.|.....:.:.:||||  ||.|:.|   ..:.:|
Zfish    25 CRDFNISL---------PEKIQALSGSCVVIKCRFDINDTYDKNLTERAAGYW------------ 68

  Fly    86 VAIGEVQLSSGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKAKGTG----ADVHQEFHNLT- 145
                   ..||..:|            ||:.:|.........||.|.||    .|....|:.:|
Zfish    69 -------FKSGTNVD------------KNLIFNSSESMQNLFIKGKITGKLTDKDCTTVFYEVTS 114

  Fly   146 -----------------------------VLTPPHPPVI-------SPGNIAVATEDKPMELTCS 174
                                         :.:|.:|.|:       ..|...| .|.:.:.|.||
Zfish   115 IHSGQYMFRIEGEGGLKWTYNKTNVSLDVIESPMNPRVVLYVDKQELQGQQEV-LEGRSVSLRCS 178

  Fly   175 --SIGGSPDPTITWYREGSNTPLPATVL--KGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAM 235
              ::..||..|:||    |:|   |.:|  :.....:..|:.|:....|......:.|.:..:..
Zfish   179 AETLCSSPPATLTW----SST---ARILLSESSKLQELINSDLNFTAARRHHRVTFTCSISYQLQ 236

  Fly   236 NEGKRLEATATLNVNYYPRV-----EVGPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFI 295
            :..:...::.||:|.|.|::     .:|          ......|.||..|. |.|.|:.:||.|
Zfish   237 DNNRTAHSSITLHVQYAPQILNSSCNIG----------NVTVCFCEVDGNPS-PVVEWHLSGRLI 290

  Fly   296 SSS----------------LVHTIHRVSVQDAGKYTCIADNGLGKT------------------- 325
            .:|                .|.::|: |:.......|::.|.||..
Zfish   291 LNSSNTFISEERLSNTSLRSVISLHQ-SLTHTNTLLCVSKNTLGNASHLFQHLPSTACDTCLSYT 354

  Fly   326 ----GEQELILDILYPPMVVI---ESKTREAEEGDTVTIRCNVTANPAPVTIEW--------LKE 375
                |...|...||...::.:   ..|.:.|:|.                  ||        :||
Zfish   355 FMLIGVPVLASAILVSVIICVRKARGKLQLAKEE------------------EWKNGSSQNAIKE 401

  Fly   376 NSPDFRYNGDVLTLTSV 392
            |..|..|    :|::||
Zfish   402 NEGDSIY----VTMSSV 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	23/135 (17%)
		I-set	146..249	CDD:254352	24/113 (21%)
		Ig	168..249	CDD:299845	18/84 (21%)
		IGc2	268..323	CDD:197706	16/70 (23%)
		Ig_3	341..406	CDD:290638	13/63 (21%)
		Ig_2	437..514	CDD:290606
		I-set	526..633	CDD:254352
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
LOC108183407	XP_021330937.1	Ig	28..142	CDD:325142	28/153 (18%)
		Ig_3	165..232	CDD:316449	18/74 (24%)
		Ig	250..335	CDD:325142	22/96 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010