DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ed and LOC101882982

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_009293582.1	Gene:	LOC101882982 / 101882982	-ID:	-	Length:	492	Species:	Danio rerio

Alignment Length:	412	Identity:	97/412 - (23%)
Similarity:	165/412 - (40%)	Gaps:	83/412 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LIALVALSSTTLADESID-------TRENADLTLKCRFNDKYEANDFSFFWTRWTANPAQFDNVA 87
            ||.|:.:...:.||..::       ..:|:.:|:.|.|.  |....:......|     ..|.|.
Zfish    13 LIFLLIIHRVSAADWGVNYSPLHLCALKNSTMTISCTFT--YPTPGYQIMTVFW-----NIDFVK 70

  Fly    88 IGEVQLSSGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIK-AKGTGADVHQEFH----NLTV- 146
            .| |:|:.   |...||   |..:::.:...:.|    |.:: :..|..|.|..|.    |:|.
Zfish    71 NG-VELAD---LSVDPE---YSQRLQYLGDEQQN----CTVRLSHVTKKDEHDYFFKFNTNVTKG 124

  Fly   147 ---------LTPPHPPVISPGNIAVATEDKPMELTCSSIGGSPD-PTITWYREGSNTPLPATVLK 201
                     |:.....:.||..:   ||...:.|||:|.....| ||..|||...      |:..
Zfish   125 RWTGIPGVRLSVTDLQLESPERV---TEGDSVRLTCNSSCELTDTPTFIWYRNSH------TLTN 180

  Fly   202 GGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEVGPENP---- 262
            .|.:       |:|......:...|.|.|:.:..     :.....|||.|      .|::|
Zfish   181 IGDE-------LNIRSVSRTEAGHYSCGVQGQTY-----ISPAVYLNVRY------APDSPVISI 227

  Fly   263 ----LRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYTCIADNGLG 323
                :.:|.| :..|.|:.|:.|...|..|.:....:.|..:..|.::|..|:|:|.|.|.|.||
Zfish   228 SGSAVIMEGD-SVSLNCSSDSNPPALNFSWFKGETLVGSGGIFNISKISSDDSGEYKCRARNDLG 291

  Fly   324 KTGEQELILDILYPPMVVIESKTREA--EEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYNGDV 386
            :.....:.:|:.|||..::.|.:..|  ..||:||:.|:..:||. ..|.|.|..:  :..:..:
Zfish   292 EKYSDPVTVDVQYPPRSILVSISGSAVIMSGDSVTLSCSSDSNPL-AEINWFKGET--YLNSERI 353

  Fly   387 LTLTSVRADHA-GNYICRAVNI 407
            ..::.:.:|.: ..|.|||.|:
Zfish   354 FNISKISSDDSEEEYKCRARNV 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	23/111 (21%)
		I-set	146..249	CDD:254352	23/113 (20%)
		Ig	168..249	CDD:299845	18/81 (22%)
		IGc2	268..323	CDD:197706	16/54 (30%)
		Ig_3	341..406	CDD:290638	17/67 (25%)
		Ig_2	437..514	CDD:290606
		I-set	526..633	CDD:254352
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
LOC101882982	XP_009293582.1	Ig	42..125	CDD:299845	22/100 (22%)
		IG_like	143..202	CDD:214653	20/74 (27%)
		Ig_2	143..>200	CDD:290606	19/72 (26%)
		Ig_2	223..302	CDD:290606	20/79 (25%)
		IG_like	228..302	CDD:214653	19/74 (26%)
		IG_like	314..381	CDD:214653	17/65 (26%)
		IGc2	321..377	CDD:197706	16/58 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010