DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ed and LOC100536326

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_021325377.1	Gene:	LOC100536326 / 100536326	-ID:	-	Length:	421	Species:	Danio rerio

Alignment Length:	464	Identity:	98/464 - (21%)
Similarity:	166/464 - (35%)	Gaps:	109/464 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IVNSRSARRAATTICNFFLIALVAL-SSTTLADESIDTREN------ADLTLKCRFNDKYEANDF 69
            |:|||.          |.||.|:.: .|.||...|:..:|:      :.:||.|.::  |..|..
Zfish     7 IMNSRL----------FPLILLLHIPGSLTLQSLSVACKESVCAVKGSQVTLVCSYS--YRNNFK 59

  Fly    70 SFFW------TRWTAN----PAQFDNVAIGEVQLSSGYRLDFQPERGIYDLQIKNVSYNRDNGRF 124
            :.||      ..|..|    ....|:...|.|:.|..|...        .|.|.:|. .||:|.:
Zfish    60 TAFWFSQKQNINWRKNNEPEDLTLDSDYSGRVKSSISYYTS--------TLTISDVR-ERDSGEY 115

  Fly   125 ECRIKAKGTGADVHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTCSSIGGSPDPTITWYRE 189
            :.....|.....:.....||||.........:|       .|:.:||.|.|...|.|.:..| :.
Zfish   116 QLMFIMKDGDKHLASVSINLTVTDLKMRMTTNP-------RDQTVELACDSYCSSKDWSYYW-KN 172

  Fly   190 GS---NTPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRN-------------RAMNEG 238
            |:   |:..|.|.:   ..::...:.|..:.:...:.:...||.::             ..:|..
Zfish   173 GNIKYNSFSPKTFV---VPNKNVYSHLCSVDQNIKNPSSSVCVSKSGCWDVSYTSTRICAVINST 234

  Fly   239 KRLEAT------ATLNVNYYPRVEVGPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISS 297
            ..:..|      .|:|..::...:.|....|..|.....::|                   |:.:
Zfish   235 VDISCTYSHPSDYTINKTFWHYGQTGGFRDLCEEHQFAGRVE-------------------FVEN 280

  Fly   298 SLVHTIHRVSVQDAGKY--TCIADNGLGK-TGEQELILDILYPPMVVIESKTREAEEGDTVTIRC 359
            .|  .|.::.:.|:|:|  ..|.|...|| :|...:||.:....::   |:.....||:.|.:.|
Zfish   281 KL--RIKKLKISDSGEYRFRIITDKTEGKYSGSPGVILTVTDTQVI---SRPHTVSEGEKVILSC 340

  Fly   360 NVTANPA-PVTIEWLKEN---SPDF-RYNGDVLTLTSVRADHAGNYICRAVNIMQSQGMERSERV 419
            :.....: ..|..|.|..   :..| :||  .|.|.||..:....:.| ||..|..   |.:..:
Zfish   341 STKCTLSNKHTYIWYKNGRQVTDGFTKYN--KLYLDSVSNEELQEFSC-AVREMSP---EVNTAL 399

  Fly   420 GNSTVALLV 428
            .|:.:.|.|
Zfish   400 QNTLIVLFV 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	25/112 (22%)
		I-set	146..249	CDD:254352	20/124 (16%)
		Ig	168..249	CDD:299845	17/102 (17%)
		IGc2	268..323	CDD:197706	9/56 (16%)
		Ig_3	341..406	CDD:290638	17/69 (25%)
		Ig_2	437..514	CDD:290606
		I-set	526..633	CDD:254352
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
LOC100536326	XP_021325377.1	IG_like	36..137	CDD:214653	24/111 (22%)
LOC100536326	XP_021325377.1	Ig	222..319	CDD:325142	21/117 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010