DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ed and kirrel2

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_001135598.1	Gene:	kirrel2 / 100216155	XenbaseID:	XB-GENE-854070	Length:	780	Species:	Xenopus tropicalis

Alignment Length:	471	Identity:	132/471 - (28%)
Similarity:	201/471 - (42%)	Gaps:	78/471 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 RWTANPAQFDNVAIG-EVQLS--SGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKAKGTGAD 136
            :||     .|.:|:| |..|.  |.|.:...|..|.::|.|:.|..: |:..:||    :.|.|.
Frog    53 QWT-----MDGLALGAERDLPGWSRYSVVGDPSLGEHNLHIEGVELS-DDAIYEC----QATQAA 107

  Fly   137 VHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTCSSIGGSPDPTITWYREGSNTPLPATV-- 199
            :..:...||||.||..|:|....:|....:.|..|||.:....|...|||||:|..  |.:.|
Frog   108 LRSQRARLTVLLPPGDPMIPGSPVANVLLNVPYNLTCLAPVAKPAAEITWYRDGKK--LDSAVYT 170

  Fly   200 --LKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEVGPENP 262
              |....|.:.:.::|.|.|...|.|:.|.|.|||.|:.||:  |.:.||:|.|.|:|.:..|.|
Frog   171 KELLSDGKSEGSASSLLITPSLADSGSSYTCRVRNEALPEGR--EKSVTLSVQYPPKVTLSVEPP 233

  Fly   263 LRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSS-------LVHTIHRVSVQDAGKYTCIADN 320
            ...|......| |...:.|:|...||.:.|..::.|       :.||.....|      :|...|
Frog   234 TITEGGSVTFL-CGAVSNPEVTGYRWAKGGVPLAVSGDKYTVEVDHTFFTAPV------SCEVSN 291

  Fly   321 GLGKTGEQELILDILYPPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYNGD 385
            .:|.:.....: ::|:.|.::.|.:....:.||..:..|..|.||.| |..|.|:.:.:...||:
Frog   292 SVGASNVSTAV-NVLFGPRLLTEPRPMTVDIGDDASFFCGWTGNPTP-TQFWSKKGTGEVLSNGN 354

  Fly   386 VLTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPVVH----V 446
            .|.||.|..:.||.|:|:|  |:...|....|      |.|.||   |...||..   :|    :
Frog   355 TLLLTKVTREDAGIYVCKA--IVPRMGSTEKE------VTLTVR---GPPIITSE---MHYETTL 405

  Fly   447 GNGVTLTCSANPPGWPVP-QYRWFRDMD-------GEFSSTQKILAQGPQYSIPKAHLGNEG--- 500
            |....:.|...  ..|.| :..|..|..       |.||...::...| ..|:    |..:|
Frog   406 GGKARMECLIE--STPAPDRIVWAWDKQSLEDGSWGRFSVETEVTEVG-AISV----LVIDGAEQ 463

  Fly   501 -----KYHCHAVNELG 511
                 :::|.|:|:.|
Frog   464 SDFLTEFNCSAINQYG 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	21/74 (28%)
		I-set	146..249	CDD:254352	38/106 (36%)
		Ig	168..249	CDD:299845	31/84 (37%)
		IGc2	268..323	CDD:197706	13/61 (21%)
		Ig_3	341..406	CDD:290638	22/64 (34%)
		Ig_2	437..514	CDD:290606	20/95 (21%)
		I-set	526..633	CDD:254352
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
kirrel2	NP_001135598.1	IG_like	28..117	CDD:214653	20/73 (27%)
		Ig2_KIRREL3-like	139..220	CDD:143236	31/84 (37%)
		Ig_2	225..294	CDD:372793	17/75 (23%)
		Ig	308..389	CDD:386229	28/89 (31%)
		Ig	391..488	CDD:386229	21/99 (21%)
		Atrophin-1	529..>765	CDD:367360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11157
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000