DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and LOC100151328

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_017211407.2	Gene:	LOC100151328 / 100151328	-ID:	-	Length:	594	Species:	Danio rerio

Alignment Length:	690	Identity:	151/690 - (21%)
Similarity:	256/690 - (37%)	Gaps:	161/690 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RAATTICNFFLIALVALSS----TTLADESIDTRENADLTLKCRFNDKYEANDFSF---FWTR-W 76
            |.|..:...||:.:..:|:    ...:...|...:|:.:|:.|.|.  |....:..   ||.: .
Zfish     6 RMAPALHLIFLLIIHRVSAAGWGVNYSPSQICALQNSSVTISCTFT--YPTPGYQIMKVFWNKDL 68

  Fly    77 TANPAQFDNVA-----------IGEVQLSSGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKA 130
            ..|..:|.:::           :|:.:.:...||             .:|:.| |...:..||..
Zfish    69 VKNGGEFADLSEDPEYSQRLQYLGDKKQNCTIRL-------------SHVTKN-DEHEYYFRITT 119

  Fly   131 KGTGA------DVHQEFHNLTVLTP-----------PHPP---VISPGNIAVATEDKPMELTCSS 175
            ..||.      .||....:|.:.:|           .:||   .:|....||..:...:.|.|||
Zfish   120 NVTGGRIIGIPGVHLNVTDLQLESPERVTEGDSVRLTYPPKNVSVSINVSAVVVKGDSVSLICSS 184

  Fly   176 IGGSPDPTITWYREGSNTPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKR 240
            ....|....:|::              |.....:....:|.....||..:|||..||..   |::
Zfish   185 DSNPPALNFSWFK--------------GETSVGSGRIFNISKISSDDSGEYKCRARNYL---GEK 232

  Fly   241 LEATATLNV-----------NYYPRVEVGPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRF 294
            ..|..||:|           :.||     .|:.|.             |:.|...|..|.:....
Zfish   233 YSAPVTLDVQCEFMNILQGMSQYP-----SEDLLS-------------DSNPPALNFSWFKGDTS 279

  Fly   295 ISSSLVHTIHRVSVQDAGKYTCIADNGLGKTGEQELILDILYPPMVVIESKTREA--EEGDTVTI 357
            :.|..:..|.::|..|:|:|.|.|.|..|:.....:.||:.|.|..:..|.:..|  ..||:||:
Zfish   280 VGSGRIFNISKISSDDSGEYKCRAKNDHGEKYSDPVTLDVQYAPRNISVSISGSAVIMSGDSVTL 344

  Fly   358 RCNVTANPAPVTIEWLKENSPDFRYNGDVLTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNS 422
            .|:..:||. ..|.|.|..:  |..:|.:..::.:.:|.:|.|.|||.|   ..|.|.|:
Zfish   345 NCSSDSNPL-AEINWFKGET--FVGSGRIFNISKISSDDSGEYKCRARN---EHGEEYSD----- 398

  Fly   423 TVALLVRHRPGQAYIT-PNKPVVHVGNGVTLTCS--ANPPGWPVPQYRWFRDMDGEFSSTQKILA 484
            .|.|.|::.|....:: ....|:..|:.|||:||  :|||.    :..||:   ||.|     :.
Zfish   399 PVTLDVQYPPRNVSVSISGSAVILSGDSVTLSCSSDSNPPA----EINWFK---GETS-----VG 451

  Fly   485 QGPQYSIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTRRVADTDYTVTC 549
            .|..::|.|....:.|:|.|.|.|..|......:.|::..||:.::.........::....|:.|
Zfish   452 SGRFFNISKISSDDSGEYKCRARNAHGEKYSDPVTLDVQYPPRNISVSVSGSHVVMSGDSVTLNC 516

  Fly   550 SAKGKPAPSVKWLKDAVEILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRG 614
            |:...|...:.|.|                       |...|.|...|      :.:.:...|.|
Zfish   517 SSDSNPPAEISWFK-----------------------GETLVGSGRIF------SISKISSDDSG 552

  Fly   615 LYTCLYQNEVNSANS---SMQLRIEHEPIVLHQYNKVAFD 651
            .|.|..:|:.....|   ::.::.|...:.|.:..|..|:
Zfish   553 EYKCRARNDHGEKYSDPVTLDVQCEFMMVQLLKLTKAVFE 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	22/117 (19%)
		I-set	146..249	CDD:254352	25/116 (22%)
		Ig	168..249	CDD:299845	19/80 (24%)
		IGc2	268..323	CDD:197706	13/54 (24%)
		Ig_3	341..406	CDD:290638	20/66 (30%)
		Ig_2	437..514	CDD:290606	24/79 (30%)
		I-set	526..633	CDD:254352	17/109 (16%)
		Ig	546..632	CDD:143165	16/88 (18%)
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
LOC100151328	XP_017211407.2	V-set	31..137	CDD:311561	22/121 (18%)
		Ig_2	169..241	CDD:316418	21/88 (24%)
		Ig_2	<262..319	CDD:316418	15/69 (22%)
		Ig_2	333..404	CDD:316418	25/81 (31%)
		Ig_2	424..489	CDD:316418	24/76 (32%)
		Ig_2	509..574	CDD:316418	16/93 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010