DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ed and si:ch211-1f22.16

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_021333326.1	Gene:	si:ch211-1f22.16 / 100150873	ZFINID:	ZDB-GENE-121214-59	Length:	322	Species:	Danio rerio

Alignment Length:	295	Identity:	78/295 - (26%)
Similarity:	119/295 - (40%)	Gaps:	50/295 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 AVATEDKPMELTCSSIGGSPDPTITWYREGSNTPLPATVLKGGTKDQPTNATLSIIPRREDDGAK 225
            ||......:.|:||| ..:|...|.|::              .||...:....:|.....||..:
Zfish     7 AVIMSGDSVTLSCSS-DSNPLAEINWFK--------------ATKYIGSGRIFNISKISSDDSGE 56

  Fly   226 YKCVVRNRAMNEGKRLEATATLNVNYYPR-VEVGPENPLRVERDRTAKLECNVDAKPKVPNVRWN 289
            |||..||   :.|::.....||:|.|.|| :.|....|..:....:..|.|:.|:.|.. .:.|.
Zfish    57 YKCRARN---DHGEKYSDPVTLDVQYPPRNISVSLSGPSVIMSGDSVTLSCSSDSNPPA-QISWF 117

  Fly   290 RNGRFISSSLVHTIHRVSVQDAGKYTCIADNGLGKTGEQELILDILYPPMVVIESKTREAE-EGD 353
            :....:.|..:..|.::|..|:|:|.|.|.|..|:.....:.||:.|||..|:.|.|...: ..|
Zfish   118 KGETSVGSGRIFNISKISSDDSGEYKCRARNEHGEKYSDPVTLDVQYPPRNVLVSVTDSGQLFSD 182

  Fly   354 TVTIRCNVTANPAPVTIEWLKENSPDFRYNGDVLTLTSVRADHAGNYICRAVNIMQSQGMERSER 418
            :|::.|...:||..:...|.|||......:|.     |..|..:|.:.|.|.|   ..|.:||:.
Zfish   183 SVSLMCISDSNPPALNFSWFKENQSSAVGSGQ-----SFSAVQSGRFYCEAHN---PHGAQRSDA 239

  Fly   419 VGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLT 453
            |   ||                  .|..|.|.|:|
Zfish   240 V---TV------------------TVQQGAGRTMT 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845
		I-set	146..249	CDD:254352	22/87 (25%)
		Ig	168..249	CDD:299845	20/80 (25%)
		IGc2	268..323	CDD:197706	14/54 (26%)
		Ig_3	341..406	CDD:290638	18/65 (28%)
		Ig_2	437..514	CDD:290606	5/17 (29%)
		I-set	526..633	CDD:254352
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
si:ch211-1f22.16	XP_021333326.1	Ig_2	6..77	CDD:316418	22/87 (25%)
		Ig_2	91..162	CDD:316418	17/71 (24%)
		Ig_2	181..244	CDD:316418	22/91 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010