DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and LOC100150424

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_017211411.2	Gene:	LOC100150424 / 100150424	-ID:	-	Length:	507	Species:	Danio rerio

Alignment Length:	470	Identity:	108/470 - (22%)
Similarity:	173/470 - (36%)	Gaps:	120/470 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LIALVALSSTTLAD-------ESIDTRENADLTLKCRFNDKYEANDFSF---FWTRWTANPAQFD 84
            ||.|:.:...:.||       ..|...:|:.:|:.|.|.  |....:..   ||.:        |
Zfish    13 LIFLLIIHRVSAADWGVIYNPSQICALQNSTMTISCTFT--YPTPGYQIMKVFWNK--------D 67

  Fly    85 NVAIGE--VQLSSGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIK-AKGTGADVHQEFHNLTV 146
            .|..|.  ..||.      .||   |..:::.:...:.|    |.:: :..|..|.|:.....|.
Zfish    68 QVYYGGEFADLSE------DPE---YSQRLQYLGDKQQN----CTVRLSHVTEKDEHEYLFRFTT 119

  Fly   147 --------------LTPPHPPVISPGNIAVATEDKPMELTCS-SIGGSPDPTITWYREGSNTPLP 196
                          |:.....:.||..:   ||...:.|||. |...:..||..|||...
Zfish   120 DVTGGIWLGKPGVRLSVTDLQLESPERV---TEGDSVRLTCKRSCKLTDTPTFIWYRNSH----- 176

  Fly   197 ATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEVGPEN 261
             |:...|.:     ..:|.:.|.|  ...|.|.|:.:..     :.....||:.|      ||:.
Zfish   177 -TLTNIGEE-----LNISSVSRTE--AGHYSCGVQGQTY-----ISPAVYLNITY------GPDT 222

  Fly   262 P--------LRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYTCIA 318
            |        :.||.| :..|.|:.|:.|...:..|.:....:.|..:..|.::|..|:|:|.|.|
Zfish   223 PVISISGSAVIVEGD-SVTLNCSSDSNPPALSFSWFKEATSVGSGRIFNISKISSDDSGEYKCRA 286

  Fly   319 DNGLGKTGEQELILDILYPPMVVIESKTREAEE--GDTVTIRCNVTANPAPVTIEWLK-ENSPDF 380
            .|..|......:.||:.|||..|..|.:..|.:  ||:|::.|:..:||..:...|.| |.|.
Zfish   287 RNDHGVNDSDPVTLDVQYPPKSVSVSISGSAVKMFGDSVSLSCSSDSNPPALNFSWYKGETSV-- 349

  Fly   381 RYNGDVLTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPVVH 445
             .:|.:|.::.:   .:|::.|...|   ..|.:||:.|   ||                  .||
Zfish   350 -RSGRILNISKI---SSGHFHCETHN---PHGAQRSDAV---TV------------------TVH 386

  Fly   446 VGNGVTLTCSANPPG 460
            .|.|..:...|...|
Zfish   387 QGAGRNIIIIAATSG 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	21/116 (18%)
		I-set	146..249	CDD:254352	23/117 (20%)
		Ig	168..249	CDD:299845	18/81 (22%)
		IGc2	268..323	CDD:197706	15/54 (28%)
		Ig_3	341..406	CDD:290638	17/67 (25%)
		Ig_2	437..514	CDD:290606	6/24 (25%)
		I-set	526..633	CDD:254352
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
LOC100150424	XP_017211411.2	Ig	27..117	CDD:325142	21/112 (19%)
		IGc2	149..200	CDD:197706	16/63 (25%)
		Ig_2	223..302	CDD:316418	20/79 (25%)
		Ig_2	<334..385	CDD:316418	17/80 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010